ID   H2A2_LILLO              Reviewed;         128 AA.
AC   Q9LD75;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Histone H2A.2;
DE   AltName: Full=GH2A;
GN   Name=gH2A;
OS   Lilium longiflorum (Trumpet lily).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Liliales; Liliaceae; Lilium.
OX   NCBI_TaxID=4690;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   STRAIN=cv. Georgia; TISSUE=Pollen;
RX   PubMed=10794571; DOI=10.1007/s004120050401;
RA   Ueda K., Kinoshita Y., Xu Z.-J., Ide N., Ono M., Akahori Y., Tanaka I.,
RA   Inoue M.;
RT   "Unusual core histones specifically expressed in male gametic cells of
RT   Lilium longiflorum.";
RL   Chromosoma 108:491-500(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-12, TISSUE
RP   SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   STRAIN=cv. Georgia; TISSUE=Leaf;
RX   PubMed=16247554; DOI=10.1007/s11103-005-8521-9;
RA   Ueda K., Suzuki M., Ono M., Ide N., Tanaka I., Inoue M.;
RT   "Male gametic cell-specific histone gH2A gene of Lilium longiflorum:
RT   genomic structure and promoter activity in the generative cell.";
RL   Plant Mol. Biol. 59:229-238(2005).
CC   -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC       DNA into chromatin, limiting DNA accessibility to the cellular
CC       machineries which require DNA as a template. Histones thereby play a
CC       central role in transcription regulation, DNA repair, DNA replication
CC       and chromosomal stability. DNA accessibility is regulated via a complex
CC       set of post-translational modifications of histones, also called
CC       histone code, and nucleosome remodeling. May be involved in the
CC       repression of gene expression in male gametes.
CC   -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC       each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC       two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC       DNA.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in the generative cell within the
CC       bicellular pollen. Not detected in other reproductive or vegetative
CC       tissues. {ECO:0000269|PubMed:10794571, ECO:0000269|PubMed:16247554}.
CC   -!- DEVELOPMENTAL STAGE: Associated with the differentiation of male
CC       gametic cells during pollen maturation. {ECO:0000269|PubMed:10794571,
CC       ECO:0000269|PubMed:16247554}.
CC   -!- SIMILARITY: Belongs to the histone H2A family. {ECO:0000305}.
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DR   EMBL; AB003781; BAA96096.1; -; mRNA.
DR   EMBL; AB003782; BAA96097.1; -; mRNA.
DR   EMBL; AB175889; BAE47493.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9LD75; -.
DR   SMR; Q9LD75; -.
DR   GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   CDD; cd00074; H2A; 1.
DR   Gene3D; 1.10.20.10; -; 1.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR002119; Histone_H2A.
DR   InterPro; IPR007125; Histone_H2A/H2B/H3.
DR   InterPro; IPR032454; Histone_H2A_C.
DR   PANTHER; PTHR23430; PTHR23430; 1.
DR   Pfam; PF00125; Histone; 1.
DR   Pfam; PF16211; Histone_H2A_C; 1.
DR   PRINTS; PR00620; HISTONEH2A.
DR   SMART; SM00414; H2A; 1.
DR   SUPFAM; SSF47113; SSF47113; 1.
PE   1: Evidence at protein level;
KW   Chromosome; Direct protein sequencing; DNA-binding; Nucleosome core;
KW   Nucleus.
FT   CHAIN           1..128
FT                   /note="Histone H2A.2"
FT                   /id="PRO_0000240654"
SQ   SEQUENCE   128 AA;  14302 MW;  E9618C3B59D3608E CRC64;
     MISSANNKGA GTSRRKLRSE KAALQFSVSR VEYSLKKGRY CRRLGATAPV YLAAVLENLV
     AEVLEMAANV TEKHKRIVIK PRHIMLAVRN DVEVNKLFHG VTISASGVVP KTRKELDRRK
     RRSTSQAD