ID   H2A4_VOLCA              Reviewed;         129 AA.
AC   P16866;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Histone H2A-IV;
OS   Volvox carteri (Green alga).
OC   Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC   CS clade; Chlamydomonadales; Volvocaceae; Volvox.
OX   NCBI_TaxID=3067;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=f. Nagariensis / HK10;
RX   PubMed=2227431; DOI=10.1016/0378-1119(90)90221-c;
RA   Mueller K., Lindauer A., Bruederlein M., Schmitt R.;
RT   "Organization and transcription of Volvox histone-encoding genes:
RT   similarities between algal and animal genes.";
RL   Gene 93:167-175(1990).
CC   -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC       DNA into chromatin, limiting DNA accessibility to the cellular
CC       machineries which require DNA as a template. Histones thereby play a
CC       central role in transcription regulation, DNA repair, DNA replication
CC       and chromosomal stability. DNA accessibility is regulated via a complex
CC       set of post-translational modifications of histones, also called
CC       histone code, and nucleosome remodeling.
CC   -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC       each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC       two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC       DNA.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC   -!- SIMILARITY: Belongs to the histone H2A family. {ECO:0000305}.
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DR   EMBL; M31922; AAA34249.1; -; Genomic_DNA.
DR   PIR; JQ0796; JQ0796.
DR   AlphaFoldDB; P16866; -.
DR   SMR; P16866; -.
DR   PRIDE; P16866; -.
DR   OMA; FQMAGRG; -.
DR   GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   CDD; cd00074; H2A; 1.
DR   Gene3D; 1.10.20.10; -; 1.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR002119; Histone_H2A.
DR   InterPro; IPR007125; Histone_H2A/H2B/H3.
DR   InterPro; IPR032454; Histone_H2A_C.
DR   InterPro; IPR032458; Histone_H2A_CS.
DR   PANTHER; PTHR23430; PTHR23430; 1.
DR   Pfam; PF00125; Histone; 1.
DR   Pfam; PF16211; Histone_H2A_C; 1.
DR   PRINTS; PR00620; HISTONEH2A.
DR   SMART; SM00414; H2A; 1.
DR   SUPFAM; SSF47113; SSF47113; 1.
DR   PROSITE; PS00046; HISTONE_H2A; 1.
PE   3: Inferred from homology;
KW   Chromosome; DNA-binding; Nucleosome core; Nucleus.
FT   CHAIN           1..129
FT                   /note="Histone H2A-IV"
FT                   /id="PRO_0000055290"
SQ   SEQUENCE   129 AA;  13570 MW;  31E750BEED029C7C CRC64;
     MAGRGKGKTA GKKAVSRSSK AGLQFPVGRI ARYLKKGKYA ERIGAGAPVY LAAVLEYLTA
     EVLELAGNAA RDNKKNRIVP RHIQLAIRND EELGKLLGDV TIASGGVLPN IHAVLLPKKS
     KGGKGEEAA