H2A4_WHEAT
ID H2A4_WHEAT Reviewed; 135 AA.
AC Q43208;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Histone H2A.4;
GN Name=TH254;
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE, AND TISSUE
RP SPECIFICITY.
RX PubMed=9106503; DOI=10.1023/a:1005768104540;
RA Huh G.H., Nakayama T., Meshi T., Iwabuchi M.;
RT "Structural characteristics of two wheat histone H2A genes encoding
RT distinct types of variants and functional differences in their promoter
RT activity.";
RL Plant Mol. Biol. 33:791-802(1997).
CC -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC DNA into chromatin, limiting DNA accessibility to the cellular
CC machineries which require DNA as a template. Histones thereby play a
CC central role in transcription regulation, DNA repair, DNA replication
CC and chromosomal stability. DNA accessibility is regulated via a complex
CC set of post-translational modifications of histones, also called
CC histone code, and nucleosome remodeling.
CC -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC DNA.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed preferentially in meristematic tissues of
CC young seedlings, in stigma and ovary but not in pollen.
CC {ECO:0000269|PubMed:9106503}.
CC -!- DEVELOPMENTAL STAGE: S phase-specific expression.
CC {ECO:0000269|PubMed:9106503}.
CC -!- SIMILARITY: Belongs to the histone H2A family. {ECO:0000305}.
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DR EMBL; X94693; CAA64356.1; -; Genomic_DNA.
DR EMBL; L75824; AAL40108.1; -; Genomic_DNA.
DR PIR; T06511; T06511.
DR AlphaFoldDB; Q43208; -.
DR SMR; Q43208; -.
DR STRING; 4565.Traes_2BS_CAA1398DB.1; -.
DR PRIDE; Q43208; -.
DR eggNOG; KOG1756; Eukaryota.
DR Proteomes; UP000019116; Unplaced.
DR ExpressionAtlas; Q43208; baseline and differential.
DR GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR CDD; cd00074; H2A; 1.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR002119; Histone_H2A.
DR InterPro; IPR007125; Histone_H2A/H2B/H3.
DR InterPro; IPR032454; Histone_H2A_C.
DR InterPro; IPR032458; Histone_H2A_CS.
DR PANTHER; PTHR23430; PTHR23430; 1.
DR Pfam; PF00125; Histone; 1.
DR Pfam; PF16211; Histone_H2A_C; 1.
DR PRINTS; PR00620; HISTONEH2A.
DR SMART; SM00414; H2A; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
DR PROSITE; PS00046; HISTONE_H2A; 1.
PE 2: Evidence at transcript level;
KW Chromosome; DNA-binding; Nucleosome core; Nucleus; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..135
FT /note="Histone H2A.4"
FT /id="PRO_0000244647"
SQ SEQUENCE 135 AA; 14102 MW; 4E399E56AC19CFF1 CRC64;
MAGRGKAIGA GAAKKATSRS SKAGLQFPVG RIARFLKAGK YAERVGAGAP VYLAAVLEYL
AAEVLELAGN AARDNKKTRI VPRHIQLAVR NDEELTKLLG GATIASGGVM PNIHQHLLPK
KASSSKVSTV DDDDN
