H2A5_WHEAT
ID H2A5_WHEAT Reviewed; 145 AA.
AC Q43213;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Protein H2A.5;
DE AltName: Full=wcH2A-2;
GN Name=H2A-2;
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RX PubMed=7893754; DOI=10.1016/0167-4781(95)00017-b;
RA Huh G.H., Matsuura Y., Meshi T., Iwabuchi M.;
RT "Differential expression of the two types of histone H2A genes in wheat.";
RL Biochim. Biophys. Acta 1261:155-160(1995).
CC -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC DNA into chromatin, limiting DNA accessibility to the cellular
CC machineries which require DNA as a template. Histones thereby play a
CC central role in transcription regulation, DNA repair, DNA replication
CC and chromosomal stability. DNA accessibility is regulated via a complex
CC set of post-translational modifications of histones, also called
CC histone code, and nucleosome remodeling.
CC -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC DNA.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Abundant in meristematic tissues.
CC {ECO:0000269|PubMed:7893754}.
CC -!- DEVELOPMENTAL STAGE: Induced during germination.
CC {ECO:0000269|PubMed:7893754}.
CC -!- DOMAIN: Contains one SPKK motif which may interact with the minor
CC groove of A/T-rich DNA sites. Phosphorylation of this motif may
CC regulate DNA binding. This motif is reiterated in both termini of
CC histone H1 and in the N-terminus of sea urchin histones H2B, but its
CC presence in the C-terminus seems to be unique to plant H2A.
CC -!- SIMILARITY: Belongs to the histone H2A family. {ECO:0000305}.
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DR EMBL; D38087; BAA07276.1; -; mRNA.
DR PIR; S53518; S53518.
DR AlphaFoldDB; Q43213; -.
DR SMR; Q43213; -.
DR EnsemblPlants; TraesCAD_scaffold_044661_01G000200.1; TraesCAD_scaffold_044661_01G000200.1; TraesCAD_scaffold_044661_01G000200.
DR EnsemblPlants; TraesCLE_scaffold_047276_01G000200.1; TraesCLE_scaffold_047276_01G000200.1; TraesCLE_scaffold_047276_01G000200.
DR EnsemblPlants; TraesCS6D02G062800.1; TraesCS6D02G062800.1; TraesCS6D02G062800.
DR EnsemblPlants; TraesPAR_scaffold_047534_01G000200.1; TraesPAR_scaffold_047534_01G000200.1; TraesPAR_scaffold_047534_01G000200.
DR EnsemblPlants; TraesROB_scaffold_043725_01G000200.1; TraesROB_scaffold_043725_01G000200.1; TraesROB_scaffold_043725_01G000200.
DR EnsemblPlants; TraesWEE_scaffold_043343_01G000200.1; TraesWEE_scaffold_043343_01G000200.1; TraesWEE_scaffold_043343_01G000200.
DR Gramene; TraesCAD_scaffold_044661_01G000200.1; TraesCAD_scaffold_044661_01G000200.1; TraesCAD_scaffold_044661_01G000200.
DR Gramene; TraesCLE_scaffold_047276_01G000200.1; TraesCLE_scaffold_047276_01G000200.1; TraesCLE_scaffold_047276_01G000200.
DR Gramene; TraesCS6D02G062800.1; TraesCS6D02G062800.1; TraesCS6D02G062800.
DR Gramene; TraesPAR_scaffold_047534_01G000200.1; TraesPAR_scaffold_047534_01G000200.1; TraesPAR_scaffold_047534_01G000200.
DR Gramene; TraesROB_scaffold_043725_01G000200.1; TraesROB_scaffold_043725_01G000200.1; TraesROB_scaffold_043725_01G000200.
DR Gramene; TraesWEE_scaffold_043343_01G000200.1; TraesWEE_scaffold_043343_01G000200.1; TraesWEE_scaffold_043343_01G000200.
DR OMA; YLKIGRY; -.
DR Proteomes; UP000019116; Unplaced.
DR GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR CDD; cd00074; H2A; 1.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR002119; Histone_H2A.
DR InterPro; IPR007125; Histone_H2A/H2B/H3.
DR InterPro; IPR032454; Histone_H2A_C.
DR InterPro; IPR032458; Histone_H2A_CS.
DR PANTHER; PTHR23430; PTHR23430; 1.
DR Pfam; PF00125; Histone; 1.
DR Pfam; PF16211; Histone_H2A_C; 1.
DR PRINTS; PR00620; HISTONEH2A.
DR SMART; SM00414; H2A; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
DR PROSITE; PS00046; HISTONE_H2A; 1.
PE 2: Evidence at transcript level;
KW Chromosome; DNA-binding; Nucleosome core; Nucleus; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..145
FT /note="Protein H2A.5"
FT /id="PRO_0000244648"
FT REGION 118..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 135..138
FT /note="SPKK motif"
FT COMPBIAS 120..145
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 145 AA; 15388 MW; CD5DA020355237A3 CRC64;
MAGRKGGDRK KAVTRSVKAG LQFPVGRIGR YLKKGRYAQR VGSGAPVYLA AVLEYLAAEV
LELAGNAAKD NKKTRIIPRH LLLAVRNDQE LGRLLAGVTI AHGGVIPNIN SVLLPKKSPA
AAEKEAKSQK AAAKSPKKKT AATKE
