ID   H2AV2_ARATH             Reviewed;         136 AA.
AC   Q9SII0;
DT   07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 139.
DE   RecName: Full=Probable histone H2A variant 2;
DE   AltName: Full=H2A.F/Z 2;
DE   AltName: Full=HTA8;
GN   OrderedLocusNames=At2g38810; ORFNames=F13I13.4;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   TISSUE SPECIFICITY, AND NOMENCLATURE.
RX   PubMed=16751347; DOI=10.1105/tpc.105.039719;
RA   Yi H., Sardesai N., Fujinuma T., Chan C.-W., Veena X., Gelvin S.B.;
RT   "Constitutive expression exposes functional redundancy between the
RT   Arabidopsis histone H2A gene HTA1 and other H2A gene family members.";
RL   Plant Cell 18:1575-1589(2006).
CC   -!- FUNCTION: Variant histones H2A are synthesized throughout the cell
CC       cycle and are very different from classical S-phase regulated H2A. May
CC       replace conventional H2A in a subset of nucleosomes. Nucleosomes wrap
CC       and compact DNA into chromatin, limiting DNA accessibility to the
CC       cellular machineries which require DNA as a template. Histones thereby
CC       play a central role in transcription regulation, DNA repair, DNA
CC       replication and chromosomal stability. DNA accessibility is regulated
CC       via a complex set of post-translational modifications of histones, also
CC       called histone code, and nucleosome remodeling (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC       each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC       two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC       DNA.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed mainly in meristems and dividing cells.
CC       In roots, restricted to the vasculature in the maturation zone.
CC       {ECO:0000269|PubMed:16751347}.
CC   -!- SIMILARITY: Belongs to the histone H2A family. {ECO:0000305}.
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DR   EMBL; AC007133; AAD25562.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC09586.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC09587.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC09588.1; -; Genomic_DNA.
DR   EMBL; CP002685; ANM62202.1; -; Genomic_DNA.
DR   EMBL; AY088573; AAM66104.1; -; mRNA.
DR   EMBL; AK220868; BAD94243.1; -; mRNA.
DR   PIR; F84809; F84809.
DR   RefSeq; NP_001318377.1; NM_001336738.1.
DR   RefSeq; NP_181415.1; NM_129438.2.
DR   RefSeq; NP_850298.1; NM_179967.2.
DR   RefSeq; NP_850299.1; NM_179968.3.
DR   AlphaFoldDB; Q9SII0; -.
DR   SMR; Q9SII0; -.
DR   BioGRID; 3805; 1.
DR   IntAct; Q9SII0; 3.
DR   STRING; 3702.AT2G38810.3; -.
DR   PaxDb; Q9SII0; -.
DR   PRIDE; Q9SII0; -.
DR   ProteomicsDB; 247210; -.
DR   EnsemblPlants; AT2G38810.1; AT2G38810.1; AT2G38810.
DR   EnsemblPlants; AT2G38810.2; AT2G38810.2; AT2G38810.
DR   EnsemblPlants; AT2G38810.3; AT2G38810.3; AT2G38810.
DR   EnsemblPlants; AT2G38810.4; AT2G38810.4; AT2G38810.
DR   GeneID; 818463; -.
DR   Gramene; AT2G38810.1; AT2G38810.1; AT2G38810.
DR   Gramene; AT2G38810.2; AT2G38810.2; AT2G38810.
DR   Gramene; AT2G38810.3; AT2G38810.3; AT2G38810.
DR   Gramene; AT2G38810.4; AT2G38810.4; AT2G38810.
DR   KEGG; ath:AT2G38810; -.
DR   Araport; AT2G38810; -.
DR   TAIR; locus:2040384; AT2G38810.
DR   eggNOG; KOG1757; Eukaryota.
DR   HOGENOM; CLU_062828_2_2_1; -.
DR   InParanoid; Q9SII0; -.
DR   OMA; HGYSWRI; -.
DR   OrthoDB; 1504122at2759; -.
DR   PhylomeDB; Q9SII0; -.
DR   PRO; PR:Q9SII0; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q9SII0; baseline and differential.
DR   Genevisible; Q9SII0; AT.
DR   GO; GO:0005730; C:nucleolus; HDA:TAIR.
DR   GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0044030; P:regulation of DNA methylation; IGI:TAIR.
DR   GO; GO:0010468; P:regulation of gene expression; IGI:TAIR.
DR   CDD; cd00074; H2A; 1.
DR   Gene3D; 1.10.20.10; -; 1.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR002119; Histone_H2A.
DR   InterPro; IPR007125; Histone_H2A/H2B/H3.
DR   InterPro; IPR032454; Histone_H2A_C.
DR   PANTHER; PTHR23430; PTHR23430; 1.
DR   Pfam; PF00125; Histone; 1.
DR   Pfam; PF16211; Histone_H2A_C; 1.
DR   PRINTS; PR00620; HISTONEH2A.
DR   SMART; SM00414; H2A; 1.
DR   SUPFAM; SSF47113; SSF47113; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; DNA-binding; Nucleosome core; Nucleus; Reference proteome.
FT   CHAIN           1..136
FT                   /note="Probable histone H2A variant 2"
FT                   /id="PRO_0000055313"
SQ   SEQUENCE   136 AA;  14370 MW;  F4F09FABFBD67A79 CRC64;
     MAGKGGKGLL AAKTTAAAAN KDSVKKKSIS RSSRAGIQFP VGRIHRQLKQ RVSAHGRVGA
     TAAVYTASIL EYLTAEVLEL AGNASKDLKV KRITPRHLQL AIRGDEELDT LIKGTIAGGG
     VIPHIHKSLV NKVTKD