ID   H2AV_DANRE              Reviewed;         128 AA.
AC   Q71PD7;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Histone H2A.V;
DE   AltName: Full=H2A.F/Z;
GN   Name=h2az2a;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND SUBCELLULAR LOCATION.
RX   PubMed=11819118; DOI=10.1007/s00427-001-0196-x;
RA   Pauls S., Geldmacher-Voss B., Campos-Ortega J.A.;
RT   "A zebrafish histone variant H2A.F/Z and a transgenic H2A.F/Z:GFP fusion
RT   protein for in vivo studies of embryonic development.";
RL   Dev. Genes Evol. 211:603-610(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=SJD;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Variant histone H2A which replaces conventional H2A in a
CC       subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin,
CC       limiting DNA accessibility to the cellular machineries which require
CC       DNA as a template. Histones thereby play a central role in
CC       transcription regulation, DNA repair, DNA replication and chromosomal
CC       stability. DNA accessibility is regulated via a complex set of post-
CC       translational modifications of histones, also called histone code, and
CC       nucleosome remodeling. May be involved in the formation of constitutive
CC       heterochromatin. May be required for chromosome segregation during cell
CC       division (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC       each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC       two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC       DNA. H2A or its variant H2AZ1 forms a heterodimer with H2B (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11819118}. Chromosome
CC       {ECO:0000269|PubMed:11819118}.
CC   -!- PTM: Monoubiquitination of Lys-122 gives a specific tag for epigenetic
CC       transcriptional repression. {ECO:0000250}.
CC   -!- PTM: Acetylated on Lys-5, Lys-8 and Lys-12 when associated with the 5'-
CC       end of active genes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the histone H2A family. {ECO:0000305}.
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DR   EMBL; AF414110; AAL10395.1; -; mRNA.
DR   EMBL; AF414111; AAL10396.1; -; Genomic_DNA.
DR   EMBL; BC049019; AAH49019.1; -; mRNA.
DR   RefSeq; NP_001188492.1; NM_001201563.1.
DR   RefSeq; NP_705930.1; NM_153644.1.
DR   AlphaFoldDB; Q71PD7; -.
DR   SMR; Q71PD7; -.
DR   STRING; 7955.ENSDARP00000090434; -.
DR   PaxDb; Q71PD7; -.
DR   Ensembl; ENSDART00000099660; ENSDARP00000090434; ENSDARG00000068820.
DR   GeneID; 252913; -.
DR   KEGG; dre:252913; -.
DR   CTD; 252913; -.
DR   ZFIN; ZDB-GENE-020717-1; h2az2a.
DR   eggNOG; KOG1757; Eukaryota.
DR   GeneTree; ENSGT00900000140979; -.
DR   HOGENOM; CLU_062828_2_2_1; -.
DR   InParanoid; Q71PD7; -.
DR   OMA; FPCGRIK; -.
DR   OrthoDB; 1504122at2759; -.
DR   PhylomeDB; Q71PD7; -.
DR   TreeFam; TF354232; -.
DR   Reactome; R-DRE-110330; Recognition and association of DNA glycosylase with site containing an affected purine.
DR   Reactome; R-DRE-110331; Cleavage of the damaged purine.
DR   Reactome; R-DRE-171306; Packaging Of Telomere Ends.
DR   Reactome; R-DRE-201722; Formation of the beta-catenin:TCF transactivating complex.
DR   Reactome; R-DRE-212300; PRC2 methylates histones and DNA.
DR   Reactome; R-DRE-2299718; Condensation of Prophase Chromosomes.
DR   Reactome; R-DRE-2559580; Oxidative Stress Induced Senescence.
DR   Reactome; R-DRE-2559582; Senescence-Associated Secretory Phenotype (SASP).
DR   Reactome; R-DRE-2559586; DNA Damage/Telomere Stress Induced Senescence.
DR   Reactome; R-DRE-3214858; RMTs methylate histone arginines.
DR   Reactome; R-DRE-427359; SIRT1 negatively regulates rRNA expression.
DR   Reactome; R-DRE-5250924; B-WICH complex positively regulates rRNA expression.
DR   Reactome; R-DRE-5578749; Transcriptional regulation by small RNAs.
DR   Reactome; R-DRE-5625886; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.
DR   Reactome; R-DRE-606279; Deposition of new CENPA-containing nucleosomes at the centromere.
DR   Reactome; R-DRE-68616; Assembly of the ORC complex at the origin of replication.
DR   Reactome; R-DRE-73728; RNA Polymerase I Promoter Opening.
DR   Reactome; R-DRE-73772; RNA Polymerase I Promoter Escape.
DR   Reactome; R-DRE-8936459; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function.
DR   Reactome; R-DRE-9018519; Estrogen-dependent gene expression.
DR   Reactome; R-DRE-9670095; Inhibition of DNA recombination at telomere.
DR   ChiTaRS; h2afva; zebrafish.
DR   PRO; PR:Q71PD7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 5.
DR   Bgee; ENSDARG00000068820; Expressed in early embryo and 26 other tissues.
DR   ExpressionAtlas; Q71PD7; baseline.
DR   GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   CDD; cd00074; H2A; 1.
DR   Gene3D; 1.10.20.10; -; 1.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR002119; Histone_H2A.
DR   InterPro; IPR007125; Histone_H2A/H2B/H3.
DR   InterPro; IPR032454; Histone_H2A_C.
DR   InterPro; IPR032458; Histone_H2A_CS.
DR   PANTHER; PTHR23430; PTHR23430; 1.
DR   Pfam; PF00125; Histone; 1.
DR   Pfam; PF16211; Histone_H2A_C; 1.
DR   PRINTS; PR00620; HISTONEH2A.
DR   SMART; SM00414; H2A; 1.
DR   SUPFAM; SSF47113; SSF47113; 1.
DR   PROSITE; PS00046; HISTONE_H2A; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Chromosome; DNA-binding; Isopeptide bond; Nucleosome core;
KW   Nucleus; Reference proteome; Ubl conjugation.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..128
FT                   /note="Histone H2A.V"
FT                   /id="PRO_0000055303"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         5
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         8
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         12
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         12
FT                   /note="N6-lactoyllysine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:P0C0S5"
FT   MOD_RES         14
FT                   /note="N6-lactoyllysine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:P0C0S5"
FT   MOD_RES         116
FT                   /note="N6-lactoyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P0C0S5"
FT   CROSSLNK        122
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in ubiquitin)"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   128 AA;  13509 MW;  1F3C388F6854041C CRC64;
     MAGGKAGKDS GKAKAKAVSR SQRAGLQFPV GRIHRHLKTR TTSHGRVGAT AAVYSAAILE
     YLTAEVLELA GNASKDLKVK RITPRHLQLA IRGDEELDSL IKATIAGGGV IPHIHKSLIG
     KKGQQKTA