ID   H2AY_TETTS              Reviewed;         388 AA.
AC   Q5Y2C3; Q24CD1;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 2.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Histone H2A.Y;
GN   Name=HTAY; ORFNames=TTHERM_01079200;
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Song X., Gorovsky M.A.;
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210;
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA   Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA   Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA   Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA   Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA   Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA   Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT   model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
CC   -!- FUNCTION: Variant histone H2A which replaces conventional H2A in a
CC       subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin,
CC       limiting DNA accessibility to the cellular machineries which require
CC       DNA as a template. Histones thereby play a central role in
CC       transcription regulation, DNA repair, DNA replication and chromosomal
CC       stability. DNA accessibility is regulated via a complex set of post-
CC       translational modifications of histones, also called histone code, and
CC       nucleosome remodeling (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC       each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC       two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the histone H2A family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAS05443.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AY706656; AAU87547.2; -; mRNA.
DR   EMBL; GG662371; EAS05443.2; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_001025688.2; XM_001025688.2.
DR   AlphaFoldDB; Q5Y2C3; -.
DR   SMR; Q5Y2C3; -.
DR   STRING; 5911.EAS05443; -.
DR   EnsemblProtists; EAS05443; EAS05443; TTHERM_01079200.
DR   GeneID; 7826370; -.
DR   KEGG; tet:TTHERM_01079200; -.
DR   eggNOG; KOG1756; Eukaryota.
DR   eggNOG; KOG2739; Eukaryota.
DR   HOGENOM; CLU_712696_0_0_1; -.
DR   InParanoid; Q5Y2C3; -.
DR   OrthoDB; 1504122at2759; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   Gene3D; 1.10.20.10; -; 1.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR002119; Histone_H2A.
DR   InterPro; IPR007125; Histone_H2A/H2B/H3.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PANTHER; PTHR23430; PTHR23430; 1.
DR   Pfam; PF00125; Histone; 1.
DR   PRINTS; PR00620; HISTONEH2A.
DR   SMART; SM00414; H2A; 1.
DR   SUPFAM; SSF47113; SSF47113; 1.
DR   PROSITE; PS51450; LRR; 4.
PE   2: Evidence at transcript level;
KW   Chromosome; DNA-binding; Leucine-rich repeat; Nucleosome core; Nucleus;
KW   Reference proteome; Repeat.
FT   CHAIN           1..388
FT                   /note="Histone H2A.Y"
FT                   /id="PRO_0000385011"
FT   REPEAT          54..75
FT                   /note="LRR 1"
FT   REPEAT          76..96
FT                   /note="LRR 2"
FT   REPEAT          100..121
FT                   /note="LRR 3"
FT   DOMAIN          134..172
FT                   /note="LRRCT"
FT   REGION          256..279
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   388 AA;  43187 MW;  05772833C57AF34F CRC64;
     MSTDQEKIIK QVLDSIAEQQ GDSRDDEVYV IEIMSLRFEK FDNRIKQKIE RFTSLQMLTI
     NDCLISDLTN FPHVPSLIRL DLVFNKITGD QLQYLRGSRH LQTLMLGANQ IEEIEDLKRL
     GQMRELIQLD LLNNPVVNTN NYRNLVFNLF PSLVILDTLD KNGIDQEKAA LDISASRVPD
     NLFDKSKPVQ NVSKQVVKNA KATQNNLFSS TQKVAQVKQI PKIVPAKVSK PSQASVQDNK
     SNVVQAKVTA AVSVGRKAPA SRNGGVPSKA GKGKMNAFSK QSTSQKSGLV FPCGRLRRYL
     KQACKQFRVS SSCNIYLAGV LEYLAAEVLE TAGNIAKNNR LSRINPVHIR EAFRNDAELN
     QFVNGTIIAE GGSTSTNFVL PIINKSKK