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H2A_CAEEL
ID   H2A_CAEEL               Reviewed;         127 AA.
AC   P09588; Q7JKF5;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 190.
DE   RecName: Full=Histone H2A;
GN   Name=his-3; ORFNames=T10C6.12;
GN   and
GN   Name=his-7; ORFNames=F45F2.4;
GN   and
GN   Name=his-12; ORFNames=ZK131.6;
GN   and
GN   Name=his-16; ORFNames=ZK131.10;
GN   and
GN   Name=his-19; ORFNames=K06C4.11;
GN   and
GN   Name=his-21; ORFNames=K06C4.3;
GN   and
GN   Name=his-30; ORFNames=F35H10.1;
GN   and
GN   Name=his-33; ORFNames=F17E9.13;
GN   and
GN   Name=his-43; ORFNames=F08G2.2;
GN   and
GN   Name=his-47; ORFNames=B0035.7;
GN   and
GN   Name=his-51; ORFNames=F07B7.10;
GN   and
GN   Name=his-53; ORFNames=F07B7.3;
GN   and
GN   Name=his-57; ORFNames=F54E12.5;
GN   and
GN   Name=his-61; ORFNames=F55G1.10;
GN   and
GN   Name=his-65; ORFNames=H02I12.7;
GN   and
GN   Name=his-68; ORFNames=T23D8.6;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2544730; DOI=10.1016/0022-2836(89)90566-4;
RA   Roberts S.B., Emmons S.W., Childs G.;
RT   "Nucleotide sequences of Caenorhabditis elegans core histone genes. Genes
RT   for different histone classes share common flanking sequence elements.";
RL   J. Mol. Biol. 206:567-577(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [3]
RP   PROTEIN SEQUENCE OF 2-127, AND ACETYLATION AT SER-2; LYS-6; LYS-9 AND
RP   LYS-11.
RC   STRAIN=DR27;
RX   PubMed=3606579; DOI=10.1042/bj2430297;
RA   Vanfleteren J.R., van Bun S.M., van Beeumen J.J.;
RT   "The primary structure of histone H2A from the nematode Caenorhabditis
RT   elegans.";
RL   Biochem. J. 243:297-300(1987).
RN   [4]
RP   PHOSPHORYLATION AT SER-2.
RX   PubMed=15133681; DOI=10.1007/s00412-004-0281-9;
RA   Barber C.M., Turner F.B., Wang Y., Hagstrom K., Taverna S.D., Mollah S.,
RA   Ueberheide B., Meyer B.J., Hunt D.F., Cheung P., Allis C.D.;
RT   "The enhancement of histone H4 and H2A serine 1 phosphorylation during
RT   mitosis and S-phase is evolutionarily conserved.";
RL   Chromosoma 112:360-371(2004).
RN   [5]
RP   UBIQUITINATION.
RX   PubMed=15525528; DOI=10.1016/j.devcel.2004.10.005;
RA   de Napoles M., Mermoud J.E., Wakao R., Tang Y.A., Endoh M., Appanah R.,
RA   Nesterova T.B., Silva J., Otte A.P., Vidal M., Koseki H., Brockdorff N.;
RT   "Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to
RT   heritable gene silencing and X inactivation.";
RL   Dev. Cell 7:663-676(2004).
CC   -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC       DNA into chromatin, limiting DNA accessibility to the cellular
CC       machineries which require DNA as a template. Histones thereby play a
CC       central role in transcription regulation, DNA repair, DNA replication
CC       and chromosomal stability. DNA accessibility is regulated via a complex
CC       set of post-translational modifications of histones, also called
CC       histone code, and nucleosome remodeling.
CC   -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC       each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC       two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC       DNA.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC   -!- PTM: Monoubiquitination of Lys-121 gives a specific tag for epigenetic
CC       transcriptional repression. {ECO:0000305}.
CC   -!- PTM: Phosphorylation on Ser-2 is enhanced during mitosis.
CC       Phosphorylation on Ser-2 directly represses transcription (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the histone H2A family. {ECO:0000305}.
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DR   EMBL; X15633; CAA33641.1; -; Genomic_DNA.
DR   EMBL; FO081169; CCD69634.1; -; Genomic_DNA.
DR   EMBL; FO081135; CCD69397.1; -; Genomic_DNA.
DR   EMBL; FO081551; CCD72371.1; -; Genomic_DNA.
DR   EMBL; FO081551; CCD72361.1; -; Genomic_DNA.
DR   EMBL; FO081223; CCD70021.1; -; Genomic_DNA.
DR   EMBL; Z73102; CAA97414.1; -; Genomic_DNA.
DR   EMBL; Z81128; CAB03399.1; -; Genomic_DNA.
DR   EMBL; Z81495; CAB04056.1; -; Genomic_DNA.
DR   EMBL; Z82271; CAB05212.1; -; Genomic_DNA.
DR   EMBL; Z83245; CAB05836.1; -; Genomic_DNA.
DR   EMBL; Z83245; CAB05838.1; -; Genomic_DNA.
DR   EMBL; Z92789; CAB07221.1; -; Genomic_DNA.
DR   EMBL; Z93388; CAB07656.1; -; Genomic_DNA.
DR   EMBL; FO081059; CCD68872.1; -; Genomic_DNA.
DR   EMBL; FO081059; CCD68866.1; -; Genomic_DNA.
DR   EMBL; FO081018; CCD68534.1; -; Genomic_DNA.
DR   PIR; S04238; HSKW2A.
DR   RefSeq; NP_492642.1; NM_060241.4.
DR   RefSeq; NP_496887.1; NM_064486.3.
DR   RefSeq; NP_496891.1; NM_064490.1.
DR   RefSeq; NP_496898.1; NM_064497.1.
DR   RefSeq; NP_501201.1; NM_068800.3.
DR   RefSeq; NP_501404.1; NM_069003.1.
DR   RefSeq; NP_501408.1; NM_069007.1.
DR   RefSeq; NP_502131.1; NM_069730.4.
DR   RefSeq; NP_502141.1; NM_069740.1.
DR   RefSeq; NP_502150.1; NM_069749.1.
DR   RefSeq; NP_505198.1; NM_072797.1.
DR   RefSeq; NP_505277.1; NM_072876.1.
DR   RefSeq; NP_505280.1; NM_072879.1.
DR   RefSeq; NP_505293.1; NM_072892.1.
DR   RefSeq; NP_505296.1; NM_072895.1.
DR   RefSeq; NP_507032.1; NM_074631.3.
DR   PDB; 6K00; X-ray; 2.20 A; D=10-121.
DR   PDB; 6K03; X-ray; 2.86 A; D=10-121.
DR   PDB; 6K09; X-ray; 2.25 A; D=10-121.
DR   PDBsum; 6K00; -.
DR   PDBsum; 6K03; -.
DR   PDBsum; 6K09; -.
DR   AlphaFoldDB; P09588; -.
DR   SMR; P09588; -.
DR   BioGRID; 38282; 2.
DR   BioGRID; 40311; 1.
DR   BioGRID; 40314; 1.
DR   BioGRID; 40320; 1.
DR   BioGRID; 42639; 2.
DR   BioGRID; 43147; 2.
DR   BioGRID; 43154; 1.
DR   BioGRID; 44299; 1.
DR   BioGRID; 44303; 1.
DR   BioGRID; 45064; 6.
DR   BioGRID; 48911; 1.
DR   BioGRID; 51394; 2.
DR   BioGRID; 56170; 2.
DR   BioGRID; 56176; 1.
DR   BioGRID; 56178; 2.
DR   BioGRID; 56827; 1.
DR   STRING; 6239.B0035.7; -.
DR   iPTMnet; P09588; -.
DR   EPD; P09588; -.
DR   PaxDb; P09588; -.
DR   PRIDE; P09588; -.
DR   EnsemblMetazoa; B0035.7.1; B0035.7.1; WBGene00001921.
DR   EnsemblMetazoa; F07B7.10.1; F07B7.10.1; WBGene00001925.
DR   EnsemblMetazoa; F07B7.3.1; F07B7.3.1; WBGene00001927.
DR   EnsemblMetazoa; F08G2.2.1; F08G2.2.1; WBGene00001917.
DR   EnsemblMetazoa; F17E9.13.1; F17E9.13.1; WBGene00001907.
DR   EnsemblMetazoa; F35H10.1.1; F35H10.1.1; WBGene00001904.
DR   EnsemblMetazoa; F45F2.4.1; F45F2.4.1; WBGene00001881.
DR   EnsemblMetazoa; F54E12.5a.1; F54E12.5a.1; WBGene00001931.
DR   EnsemblMetazoa; F55G1.10.1; F55G1.10.1; WBGene00001935.
DR   EnsemblMetazoa; H02I12.7.1; H02I12.7.1; WBGene00001939.
DR   EnsemblMetazoa; K06C4.11.1; K06C4.11.1; WBGene00001893.
DR   EnsemblMetazoa; K06C4.3.1; K06C4.3.1; WBGene00001895.
DR   EnsemblMetazoa; T10C6.12.1; T10C6.12.1; WBGene00001877.
DR   EnsemblMetazoa; T23D8.6.1; T23D8.6.1; WBGene00001942.
DR   EnsemblMetazoa; ZK131.10.1; ZK131.10.1; WBGene00001890.
DR   EnsemblMetazoa; ZK131.6.1; ZK131.6.1; WBGene00001886.
DR   GeneID; 172860; -.
DR   GeneID; 175025; -.
DR   GeneID; 175028; -.
DR   GeneID; 175034; -.
DR   GeneID; 177521; -.
DR   GeneID; 178048; -.
DR   GeneID; 178056; -.
DR   GeneID; 179261; -.
DR   GeneID; 179265; -.
DR   GeneID; 180073; -.
DR   GeneID; 184112; -.
DR   GeneID; 186671; -.
DR   GeneID; 191669; -.
DR   GeneID; 191676; -.
DR   GeneID; 191678; -.
DR   GeneID; 259800; -.
DR   KEGG; cel:CELE_B0035.7; -.
DR   KEGG; cel:CELE_F07B7.10; -.
DR   KEGG; cel:CELE_F07B7.3; -.
DR   KEGG; cel:CELE_F08G2.2; -.
DR   KEGG; cel:CELE_F17E9.13; -.
DR   KEGG; cel:CELE_F35H10.1; -.
DR   KEGG; cel:CELE_F45F2.4; -.
DR   KEGG; cel:CELE_F55G1.10; -.
DR   KEGG; cel:CELE_H02I12.7; -.
DR   KEGG; cel:CELE_K06C4.11; -.
DR   KEGG; cel:CELE_K06C4.3; -.
DR   KEGG; cel:CELE_T10C6.12; -.
DR   KEGG; cel:CELE_T23D8.6; -.
DR   KEGG; cel:CELE_ZK131.10; -.
DR   KEGG; cel:CELE_ZK131.6; -.
DR   UCSC; T23D8.6; c. elegans.
DR   CTD; 172860; -.
DR   CTD; 175025; -.
DR   CTD; 175028; -.
DR   CTD; 175034; -.
DR   CTD; 177521; -.
DR   CTD; 178048; -.
DR   CTD; 178056; -.
DR   CTD; 179261; -.
DR   CTD; 179265; -.
DR   CTD; 180073; -.
DR   CTD; 184112; -.
DR   CTD; 186671; -.
DR   CTD; 191669; -.
DR   CTD; 191676; -.
DR   CTD; 191678; -.
DR   CTD; 259800; -.
DR   WormBase; B0035.7; CE04501; WBGene00001921; his-47.
DR   WormBase; F07B7.10; CE04501; WBGene00001925; his-51.
DR   WormBase; F07B7.3; CE04501; WBGene00001927; his-53.
DR   WormBase; F08G2.2; CE04501; WBGene00001917; his-43.
DR   WormBase; F17E9.13; CE04501; WBGene00001907; his-33.
DR   WormBase; F35H10.1; CE04501; WBGene00001904; his-30.
DR   WormBase; F45F2.4; CE04501; WBGene00001881; his-7.
DR   WormBase; F54E12.5; CE04501; WBGene00001931; his-57.
DR   WormBase; F55G1.10; CE04501; WBGene00001935; his-61.
DR   WormBase; H02I12.7; CE04501; WBGene00001939; his-65.
DR   WormBase; K06C4.11; CE04501; WBGene00001893; his-19.
DR   WormBase; K06C4.3; CE04501; WBGene00001895; his-21.
DR   WormBase; T10C6.12; CE04501; WBGene00001877; his-3.
DR   WormBase; T23D8.6; CE04501; WBGene00001942; his-68.
DR   WormBase; ZK131.10; CE04501; WBGene00001890; his-16.
DR   WormBase; ZK131.6; CE04501; WBGene00001886; his-12.
DR   eggNOG; KOG1756; Eukaryota.
DR   GeneTree; ENSGT01020000230360; -.
DR   HOGENOM; CLU_062828_3_1_1; -.
DR   InParanoid; P09588; -.
DR   OrthoDB; 1504122at2759; -.
DR   PhylomeDB; P09588; -.
DR   Reactome; R-CEL-201722; Formation of the beta-catenin:TCF transactivating complex.
DR   Reactome; R-CEL-212300; PRC2 methylates histones and DNA.
DR   Reactome; R-CEL-2299718; Condensation of Prophase Chromosomes.
DR   Reactome; R-CEL-2559580; Oxidative Stress Induced Senescence.
DR   Reactome; R-CEL-3214815; HDACs deacetylate histones.
DR   Reactome; R-CEL-3214847; HATs acetylate histones.
DR   Reactome; R-CEL-3214858; RMTs methylate histone arginines.
DR   Reactome; R-CEL-427359; SIRT1 negatively regulates rRNA expression.
DR   Reactome; R-CEL-427413; NoRC negatively regulates rRNA expression.
DR   Reactome; R-CEL-5578749; Transcriptional regulation by small RNAs.
DR   Reactome; R-CEL-5625886; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.
DR   Reactome; R-CEL-5689880; Ub-specific processing proteases.
DR   Reactome; R-CEL-5689901; Metalloprotease DUBs.
DR   Reactome; R-CEL-5693565; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
DR   Reactome; R-CEL-68616; Assembly of the ORC complex at the origin of replication.
DR   Reactome; R-CEL-73772; RNA Polymerase I Promoter Escape.
DR   Reactome; R-CEL-8936459; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function.
DR   Reactome; R-CEL-9018519; Estrogen-dependent gene expression.
DR   PRO; PR:P09588; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Proteomes; UP000001940; Chromosome II.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00001877; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; NAS:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB.
DR   CDD; cd00074; H2A; 1.
DR   Gene3D; 1.10.20.10; -; 1.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR002119; Histone_H2A.
DR   InterPro; IPR007125; Histone_H2A/H2B/H3.
DR   InterPro; IPR032454; Histone_H2A_C.
DR   InterPro; IPR032458; Histone_H2A_CS.
DR   PANTHER; PTHR23430; PTHR23430; 1.
DR   Pfam; PF00125; Histone; 1.
DR   Pfam; PF16211; Histone_H2A_C; 1.
DR   PRINTS; PR00620; HISTONEH2A.
DR   SMART; SM00414; H2A; 1.
DR   SUPFAM; SSF47113; SSF47113; 1.
DR   PROSITE; PS00046; HISTONE_H2A; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Acetylation; Chromosome; Direct protein sequencing;
KW   DNA-binding; Isopeptide bond; Methylation; Nucleosome core; Nucleus;
KW   Phosphoprotein; Reference proteome; Ubl conjugation.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:3606579"
FT   CHAIN           2..127
FT                   /note="Histone H2A"
FT                   /id="PRO_0000055210"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000305|PubMed:3606579"
FT   MOD_RES         2
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000305|PubMed:15133681"
FT   MOD_RES         6
FT                   /note="N6-acetyllysine; partial"
FT                   /evidence="ECO:0000269|PubMed:3606579"
FT   MOD_RES         9
FT                   /note="N6-acetyllysine; partial"
FT                   /evidence="ECO:0000269|PubMed:3606579"
FT   MOD_RES         11
FT                   /note="N6-acetyllysine; partial"
FT                   /evidence="ECO:0000269|PubMed:3606579"
FT   MOD_RES         106
FT                   /note="N5-methylglutamine"
FT                   /evidence="ECO:0000250"
FT   CROSSLNK        121
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in ubiquitin)"
FT                   /evidence="ECO:0000305|PubMed:15525528"
FT   HELIX           19..22
FT                   /evidence="ECO:0007829|PDB:6K00"
FT   HELIX           29..38
FT                   /evidence="ECO:0007829|PDB:6K00"
FT   TURN            39..42
FT                   /evidence="ECO:0007829|PDB:6K00"
FT   STRAND          43..45
FT                   /evidence="ECO:0007829|PDB:6K03"
FT   HELIX           48..74
FT                   /evidence="ECO:0007829|PDB:6K00"
FT   STRAND          78..80
FT                   /evidence="ECO:0007829|PDB:6K00"
FT   HELIX           82..90
FT                   /evidence="ECO:0007829|PDB:6K00"
FT   HELIX           93..98
FT                   /evidence="ECO:0007829|PDB:6K00"
SQ   SEQUENCE   127 AA;  13405 MW;  FBF085558F1BD340 CRC64;
     MSGRGKGGKA KTGGKAKSRS SRAGLQFPVG RLHRILRKGN YAQRVGAGAP VYLAAVLEYL
     AAEVLELAGN AARDNKKTRI APRHLQLAVR NDEELNKLLA GVTIAQGGVL PNIQAVLLPK
     KTGGDKE
 
 
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