ID   H2A_CHLRE               Reviewed;         129 AA.
AC   P50567;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Histone H2A;
GN   Name=H2A-II;
GN   and
GN   Name=H2A-III;
OS   Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC   Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC   CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX   NCBI_TaxID=3055;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=137c / CC-125;
RX   PubMed=7479007; DOI=10.1093/nar/23.18.3756;
RA   Walther Z., Hall J.L.;
RT   "The uni chromosome of Chlamydomonas: histone genes and nucleosome
RT   structure.";
RL   Nucleic Acids Res. 23:3756-3763(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8590479; DOI=10.1007/bf00326431;
RA   Fabry S., Mueller K., Lindauer A., Park P.B., Cornelius T., Schmitt R.;
RT   "The organization structure and regulatory elements of Chlamydomonas
RT   histone genes reveal features linking plant and animal genes.";
RL   Curr. Genet. 28:333-345(1995).
CC   -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC       DNA into chromatin, limiting DNA accessibility to the cellular
CC       machineries which require DNA as a template. Histones thereby play a
CC       central role in transcription regulation, DNA repair, DNA replication
CC       and chromosomal stability. DNA accessibility is regulated via a complex
CC       set of post-translational modifications of histones, also called
CC       histone code, and nucleosome remodeling.
CC   -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC       each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC       two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC       DNA.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC   -!- SIMILARITY: Belongs to the histone H2A family. {ECO:0000305}.
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DR   EMBL; L41841; AAA99968.1; -; Genomic_DNA.
DR   EMBL; U16724; AAA98447.1; -; Genomic_DNA.
DR   EMBL; U16725; AAA98451.1; -; Genomic_DNA.
DR   PIR; S59126; S59126.
DR   RefSeq; XP_001690672.1; XM_001690620.1.
DR   RefSeq; XP_001690682.1; XM_001690630.1.
DR   RefSeq; XP_001690722.1; XM_001690670.1.
DR   RefSeq; XP_001691528.1; XM_001691476.1.
DR   RefSeq; XP_001691688.1; XM_001691636.1.
DR   RefSeq; XP_001693466.1; XM_001693414.1.
DR   RefSeq; XP_001697820.1; XM_001697768.1.
DR   RefSeq; XP_001700399.1; XM_001700347.1.
DR   RefSeq; XP_001700409.1; XM_001700357.1.
DR   RefSeq; XP_001700425.1; XM_001700373.1.
DR   RefSeq; XP_001700454.1; XM_001700402.1.
DR   AlphaFoldDB; P50567; -.
DR   SMR; P50567; -.
DR   STRING; 3055.EDO95786; -.
DR   ProMEX; P50567; -.
DR   EnsemblPlants; PNW70181; PNW70181; CHLRE_17g709200v5.
DR   EnsemblPlants; PNW70208; PNW70208; CHLRE_17g710400v5.
DR   EnsemblPlants; PNW70243; PNW70243; CHLRE_17g711700v5.
DR   EnsemblPlants; PNW70283; PNW70283; CHLRE_17g713400v5.
DR   EnsemblPlants; PNW70300; PNW70300; CHLRE_17g714100v5.
DR   EnsemblPlants; PNW70309; PNW70309; CHLRE_17g714500v5.
DR   EnsemblPlants; PNW73726; PNW73726; CHLRE_13g570100v5.
DR   EnsemblPlants; PNW82107; PNW82107; CHLRE_06g274200v5.
DR   EnsemblPlants; PNW82160; PNW82160; CHLRE_06g276500v5.
DR   EnsemblPlants; PNW82171; PNW82171; CHLRE_06g276950v5.
DR   GeneID; 5716279; -.
DR   GeneID; 5716280; -.
DR   GeneID; 5716319; -.
DR   GeneID; 5717135; -.
DR   GeneID; 5719121; -.
DR   GeneID; 5723379; -.
DR   GeneID; 5725954; -.
DR   GeneID; 5726001; -.
DR   GeneID; 5726026; -.
DR   Gramene; PNW70181; PNW70181; CHLRE_17g709200v5.
DR   Gramene; PNW70208; PNW70208; CHLRE_17g710400v5.
DR   Gramene; PNW70243; PNW70243; CHLRE_17g711700v5.
DR   Gramene; PNW70283; PNW70283; CHLRE_17g713400v5.
DR   Gramene; PNW70300; PNW70300; CHLRE_17g714100v5.
DR   Gramene; PNW70309; PNW70309; CHLRE_17g714500v5.
DR   Gramene; PNW73726; PNW73726; CHLRE_13g570100v5.
DR   Gramene; PNW82107; PNW82107; CHLRE_06g274200v5.
DR   Gramene; PNW82160; PNW82160; CHLRE_06g276500v5.
DR   Gramene; PNW82171; PNW82171; CHLRE_06g276950v5.
DR   KEGG; cre:CHLRE_06g276500v5; -.
DR   KEGG; cre:CHLRE_06g276950v5; -.
DR   KEGG; cre:CHLRE_13g570100v5; -.
DR   KEGG; cre:CHLRE_17g709200v5; -.
DR   KEGG; cre:CHLRE_17g710400v5; -.
DR   KEGG; cre:CHLRE_17g711700v5; -.
DR   KEGG; cre:CHLRE_17g713400v5; -.
DR   KEGG; cre:CHLRE_17g714100v5; -.
DR   KEGG; cre:CHLRE_17g714500v5; -.
DR   eggNOG; KOG1756; Eukaryota.
DR   HOGENOM; CLU_062828_3_0_1; -.
DR   OMA; FRFIMSS; -.
DR   OrthoDB; 1504122at2759; -.
DR   GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   CDD; cd00074; H2A; 1.
DR   Gene3D; 1.10.20.10; -; 1.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR002119; Histone_H2A.
DR   InterPro; IPR007125; Histone_H2A/H2B/H3.
DR   InterPro; IPR032454; Histone_H2A_C.
DR   InterPro; IPR032458; Histone_H2A_CS.
DR   PANTHER; PTHR23430; PTHR23430; 1.
DR   Pfam; PF00125; Histone; 1.
DR   Pfam; PF16211; Histone_H2A_C; 1.
DR   PRINTS; PR00620; HISTONEH2A.
DR   SMART; SM00414; H2A; 1.
DR   SUPFAM; SSF47113; SSF47113; 1.
DR   PROSITE; PS00046; HISTONE_H2A; 1.
PE   3: Inferred from homology;
KW   Chromosome; DNA-binding; Nucleosome core; Nucleus.
FT   CHAIN           1..129
FT                   /note="Histone H2A"
FT                   /id="PRO_0000055218"
SQ   SEQUENCE   129 AA;  13628 MW;  EB5FFBBEF2EF6AC0 CRC64;
     MAGRGKGKTS GKKAVSRSAK AGLQFPVGRI ARYLKKGKYA ERIGAGAPVY LAAVLEYLTA
     EVLELAGNAA RDNKKNRIVP RHIQLAIRND EELGKLLGEV TIASGGVLPN IHAVLLPKKT
     KGGKGEETA