H2A_DROER
ID H2A_DROER Reviewed; 124 AA.
AC P84052; B3NLS4; P02267;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Histone H2A;
GN Name=His2A; Synonyms=H2a;
GN and
GN ORFNames=GG10951;
GN and
GN ORFNames=GG10964;
GN and
GN ORFNames=GG11003;
GN and
GN ORFNames=GG11006;
GN and
GN ORFNames=GG11009;
GN and
GN ORFNames=GG11013;
GN and
GN ORFNames=GG12574;
GN and
GN ORFNames=GG12577;
GN and
GN ORFNames=GG12989;
GN and
GN ORFNames=GG13016;
GN and
GN ORFNames=GG13019;
GN and
GN ORFNames=GG13022;
GN and
GN ORFNames=GG13026;
GN and
GN ORFNames=GG13060;
GN and
GN ORFNames=GG16371;
GN and
GN ORFNames=GG18133;
GN and
GN ORFNames=GG18465;
GN and
GN ORFNames=GG19786;
GN and
GN ORFNames=GG19797;
GN and
GN ORFNames=GG19829;
GN and
GN ORFNames=GG19840;
GN and
GN ORFNames=GG19849;
GN and
GN ORFNames=GG19852;
GN and
GN ORFNames=GG21305;
GN and
GN ORFNames=GG21309;
GN and
GN ORFNames=GG21312;
GN and
GN ORFNames=GG21315;
GN and
GN ORFNames=GG21319;
GN and
GN ORFNames=GG21322;
GN and
GN ORFNames=GG21332;
OS Drosophila erecta (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7220;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (HIS2A).
RX PubMed=11922104; DOI=10.1266/ggs.76.355;
RA Tsunemoto K., Matsuo Y.;
RT "Molecular evolutionary analysis of a histone gene repeating unit from
RT Drosophila simulans.";
RL Genes Genet. Syst. 76:355-361(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (GG10951; GG10964; GG11003;
RP GG11006; GG11009; GG11013; GG12574; GG12577; GG12989; GG13016; GG13019;
RP GG13022; GG13026; GG13060; GG16371; GG18133; GG18465; GG19786; GG19797;
RP GG19829; GG19840; GG19849; GG19852; GG21305; GG21309; GG21312; GG21315;
RP GG21319; GG21322 AND GG21332).
RC STRAIN=Tucson 14021-0224.01;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC DNA into chromatin, limiting DNA accessibility to the cellular
CC machineries which require DNA as a template. Histones thereby play a
CC central role in transcription regulation, DNA repair, DNA replication
CC and chromosomal stability. DNA accessibility is regulated via a complex
CC set of post-translational modifications of histones, also called
CC histone code, and nucleosome remodeling.
CC -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC DNA.
CC -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC -!- PTM: The chromatin-associated form, but not the free cytoplasmic form,
CC is phosphorylated on Thr-120 by NHK-1 during mitosis, and
CC dephosphorylated during S-phase. Also phosphorylated on Thr-120 by NHK-
CC 1 during prophase I of meiosis; which is required for acetylation of H3
CC 'Lys-14' and H4 'Lys-5', diassembly of the synaptonemal complex, and
CC karyosome formation (By similarity). {ECO:0000250}.
CC -!- PTM: Monoubiquitination of Lys-119 by sce/dRING gives a specific tag
CC for epigenetic transcriptional repression. {ECO:0000250}.
CC -!- PTM: Phosphorylation on Ser-2 is enhanced during mitosis.
CC Phosphorylation on Ser-2 directly represses transcription (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the histone H2A family. {ECO:0000305}.
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DR EMBL; AB073634; BAC54552.1; -; Genomic_DNA.
DR EMBL; CH954179; EDV54390.1; -; Genomic_DNA.
DR EMBL; CH954179; EDV54405.1; -; Genomic_DNA.
DR EMBL; CH954179; EDV54410.1; -; Genomic_DNA.
DR EMBL; CH954179; EDV54415.1; -; Genomic_DNA.
DR EMBL; CH954179; EDV54420.1; -; Genomic_DNA.
DR EMBL; CH954179; EDV54425.1; -; Genomic_DNA.
DR EMBL; CH954179; EDV54430.1; -; Genomic_DNA.
DR EMBL; CH954354; EDV45306.1; -; Genomic_DNA.
DR EMBL; CH954354; EDV45311.1; -; Genomic_DNA.
DR EMBL; CH954354; EDV45316.1; -; Genomic_DNA.
DR EMBL; CH954354; EDV45321.1; -; Genomic_DNA.
DR EMBL; CH954357; EDV45118.1; -; Genomic_DNA.
DR EMBL; CH954357; EDV45123.1; -; Genomic_DNA.
DR EMBL; CH954357; EDV45128.1; -; Genomic_DNA.
DR EMBL; CH954357; EDV45133.1; -; Genomic_DNA.
DR EMBL; CH954440; EDV45296.1; -; Genomic_DNA.
DR EMBL; CH954440; EDV45301.1; -; Genomic_DNA.
DR EMBL; CH954690; EDV45080.1; -; Genomic_DNA.
DR EMBL; CH954690; EDV45085.1; -; Genomic_DNA.
DR EMBL; CH954812; EDV45056.1; -; Genomic_DNA.
DR EMBL; CH954812; EDV45061.1; -; Genomic_DNA.
DR EMBL; CH955254; EDV45101.1; -; Genomic_DNA.
DR EMBL; CH955280; EDV45333.1; -; Genomic_DNA.
DR EMBL; CH955409; EDV45189.1; -; Genomic_DNA.
DR EMBL; CH956180; EDV45097.1; -; Genomic_DNA.
DR EMBL; CH956541; EDV60035.1; -; Genomic_DNA.
DR EMBL; CH956753; EDV45075.1; -; Genomic_DNA.
DR EMBL; CH956850; EDV60040.1; -; Genomic_DNA.
DR EMBL; CH958597; EDV45182.1; -; Genomic_DNA.
DR EMBL; CH958931; EDV45042.1; -; Genomic_DNA.
DR RefSeq; XP_001973990.1; XM_001973954.1.
DR RefSeq; XP_001974005.1; XM_001973969.1.
DR RefSeq; XP_001974010.1; XM_001973974.1.
DR RefSeq; XP_001974015.1; XM_001973979.1.
DR RefSeq; XP_001974020.1; XM_001973984.1.
DR RefSeq; XP_001974025.1; XM_001973989.1.
DR RefSeq; XP_001974030.1; XM_001973994.1.
DR RefSeq; XP_001983153.1; XM_001983117.2.
DR AlphaFoldDB; P84052; -.
DR SMR; P84052; -.
DR EnsemblMetazoa; FBtr0139894; FBpp0138386; FBgn0112041.
DR EnsemblMetazoa; FBtr0141359; FBpp0139851; FBgn0113484.
DR EnsemblMetazoa; FBtr0141363; FBpp0139855; FBgn0113488.
DR EnsemblMetazoa; FBtr0141366; FBpp0139858; FBgn0113491.
DR EnsemblMetazoa; FBtr0141369; FBpp0139861; FBgn0113494.
DR EnsemblMetazoa; FBtr0141373; FBpp0139865; FBgn0113498.
DR EnsemblMetazoa; FBtr0141376; FBpp0139868; FBgn0113501.
DR EnsemblMetazoa; FBtr0141386; FBpp0139878; FBgn0113511.
DR GeneID; 6548669; -.
DR GeneID; 6548691; -.
DR GeneID; 6548739; -.
DR GeneID; 6549046; -.
DR KEGG; der:6548669; -.
DR KEGG; der:6548691; -.
DR KEGG; der:6548739; -.
DR KEGG; der:6549046; -.
DR FlyBase; FBgn0064619; Dere\His2A.
DR eggNOG; KOG1756; Eukaryota.
DR HOGENOM; CLU_062828_3_3_1; -.
DR OMA; RTEGKHE; -.
DR OrthoDB; 1504122at2759; -.
DR PhylomeDB; P84052; -.
DR ChiTaRS; His2Av; fly.
DR Proteomes; UP000008711; Unassembled WGS sequence.
DR GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR CDD; cd00074; H2A; 1.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR002119; Histone_H2A.
DR InterPro; IPR007125; Histone_H2A/H2B/H3.
DR InterPro; IPR032454; Histone_H2A_C.
DR InterPro; IPR032458; Histone_H2A_CS.
DR PANTHER; PTHR23430; PTHR23430; 1.
DR Pfam; PF00125; Histone; 1.
DR Pfam; PF16211; Histone_H2A_C; 1.
DR PRINTS; PR00620; HISTONEH2A.
DR SMART; SM00414; H2A; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
DR PROSITE; PS00046; HISTONE_H2A; 1.
PE 3: Inferred from homology;
KW Acetylation; Chromosome; DNA-binding; Isopeptide bond; Methylation;
KW Nucleosome core; Nucleus; Phosphoprotein; Ubl conjugation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..124
FT /note="Histone H2A"
FT /id="PRO_0000055220"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250"
FT MOD_RES 2
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
FT MOD_RES 36
FT /note="N6-succinyllysine"
FT /evidence="ECO:0000250|UniProtKB:P84051"
FT MOD_RES 104
FT /note="N5-methylglutamine"
FT /evidence="ECO:0000250"
FT MOD_RES 120
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250"
FT CROSSLNK 119
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT /evidence="ECO:0000250"
SQ SEQUENCE 124 AA; 13363 MW; 725BA63C393155F6 CRC64;
MSGRGKGGKV KGKAKSRSNR AGLQFPVGRI HRLLRKGNYA ERVGAGAPVY LAAVMEYLAA
EVLELAGNAA RDNKKTRIIP RHLQLAIRND EELNKLLSGV TIAQGGVLPN IQAVLLPKKT
EKKA
