H2A_EUPCP
ID H2A_EUPCP Reviewed; 16 AA.
AC C0HJB7;
DT 26-JUN-2013, integrated into UniProtKB/Swiss-Prot.
DT 26-JUN-2013, sequence version 1.
DT 25-MAY-2022, entry version 13.
DE RecName: Full=Buforin-EC {ECO:0000303|Ref.1};
OS Euphlyctis cyanophlyctis (Skittering frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Ranoidea; Dicroglossidae; Dicroglossinae;
OC Euphlyctis.
OX NCBI_TaxID=58519;
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, AND MASS SPECTROMETRY.
RC TISSUE=Skin secretion {ECO:0000269|Ref.1};
RX DOI=10.1007/s10989-011-9284-6;
RA Asoodeh A., Ghorani-Azam A., Chamani J.K.;
RT "Identification and characterization of novel antibacterial peptides from
RT skin secretions of Euphlyctis cyanophlyctis.";
RL Int. J. Pept. Res. Ther. 18:107-115(2012).
CC -!- FUNCTION: Has antibacterial activity against E.coli HP101BA (MIC=9.6
CC uM), K.pneumoniae PTCC1388 (MIC=10.6 uM), M.luteus PTCC1625 (MIC=6.0
CC uM) and S.aureus PTCC1431 (MIC=8.1 uM). Has no or very limited (<3%)
CC hemolytic activity at concentrations of 15 ug/ml and 60 ug/ml,
CC respectively. {ECO:0000269|Ref.1}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
CC -!- TISSUE SPECIFICITY: Expressed by the skin glands. {ECO:0000305|Ref.1}.
CC -!- MASS SPECTROMETRY: Mass=1875.05; Mass_error=0.5; Method=MALDI;
CC Evidence={ECO:0000269|Ref.1};
CC -!- SIMILARITY: Belongs to the histone H2A family. {ECO:0000255}.
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DR AlphaFoldDB; C0HJB7; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR032458; Histone_H2A_CS.
DR SUPFAM; SSF47113; SSF47113; 1.
DR PROSITE; PS00046; HISTONE_H2A; 1.
PE 1: Evidence at protein level;
KW Amphibian defense peptide; Antibiotic; Antimicrobial;
KW Direct protein sequencing; Secreted.
FT PEPTIDE 1..16
FT /note="Buforin-EC"
FT /evidence="ECO:0000303|Ref.1"
FT /id="PRO_0000422916"
SQ SEQUENCE 16 AA; 1875 MW; E02C61B2F8D91F4A CRC64;
RAGLKFPVGR VHRLLR