ID   H2A_OLILU               Reviewed;          67 AA.
AC   P82897;
DT   27-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Histone H2A;
DE   Flags: Fragment;
OS   Olisthodiscus luteus (Marine phytoflagellate).
OC   Eukaryota; Sar; Stramenopiles; Ochrophyta; Olisthodiscophyceae;
OC   Olisthodiscaceae; Olisthodiscus.
OX   NCBI_TaxID=83000;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE.
RA   Rodrigues J.A., Spit A., Brandt W.F.;
RL   Submitted (DEC-2000) to UniProtKB.
CC   -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC       DNA into chromatin, limiting DNA accessibility to the cellular
CC       machineries which require DNA as a template. Histones thereby play a
CC       central role in transcription regulation, DNA repair, DNA replication
CC       and chromosomal stability. DNA accessibility is regulated via a complex
CC       set of post-translational modifications of histones, also called
CC       histone code, and nucleosome remodeling.
CC   -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC       each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC       two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC       DNA.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC   -!- SIMILARITY: Belongs to the histone H2A family. {ECO:0000305}.
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DR   GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   Gene3D; 1.10.20.10; -; 1.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR002119; Histone_H2A.
DR   InterPro; IPR007125; Histone_H2A/H2B/H3.
DR   InterPro; IPR032454; Histone_H2A_C.
DR   PANTHER; PTHR23430; PTHR23430; 1.
DR   Pfam; PF00125; Histone; 1.
DR   Pfam; PF16211; Histone_H2A_C; 1.
DR   PRINTS; PR00620; HISTONEH2A.
DR   SMART; SM00414; H2A; 1.
DR   SUPFAM; SSF47113; SSF47113; 1.
PE   1: Evidence at protein level;
KW   Chromosome; Direct protein sequencing; DNA-binding; Methylation;
KW   Nucleosome core; Nucleus.
FT   CHAIN           <1..>67
FT                   /note="Histone H2A"
FT                   /id="PRO_0000055256"
FT   MOD_RES         60
FT                   /note="N5-methylglutamine"
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
FT                   /evidence="ECO:0000305"
FT   NON_TER         67
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   67 AA;  7064 MW;  8DD095D5452E22DD CRC64;
     AGAPVYLAAX XXYLTAEILX LAGNAARDNK KSRIIPRHVQ LAVXXXXXLN KLLGNVTIAQ
     GGVLPNI