ID   H2A_TRYCR               Reviewed;         135 AA.
AC   P35066;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   14-AUG-2001, sequence version 2.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Histone H2A;
OS   Trypanosoma cruzi.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=5693;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8078513; DOI=10.1016/0166-6851(94)90129-5;
RA   Puerta C., Martin J., Alonso C., Lopez M.C.;
RT   "Isolation and characterization of the gene encoding histone H2A from
RT   Trypanosoma cruzi.";
RL   Mol. Biochem. Parasitol. 64:1-10(1994).
RN   [2]
RP   SEQUENCE REVISION TO 5; 92 AND 106.
RA   Lopez Lopez M.C.;
RL   Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC       DNA into chromatin, limiting DNA accessibility to the cellular
CC       machineries which require DNA as a template. Histones thereby play a
CC       central role in transcription regulation, DNA repair, DNA replication
CC       and chromosomal stability. DNA accessibility is regulated via a complex
CC       set of post-translational modifications of histones, also called
CC       histone code, and nucleosome remodeling.
CC   -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC       each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC       two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC       DNA.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC   -!- SIMILARITY: Belongs to the histone H2A family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X67287; CAA47703.2; -; Genomic_DNA.
DR   PIR; S25119; S25119.
DR   AlphaFoldDB; P35066; -.
DR   SMR; P35066; -.
DR   VEuPathDB; TriTrypDB:BCY84_17372; -.
DR   VEuPathDB; TriTrypDB:C3747_22g1865c; -.
DR   VEuPathDB; TriTrypDB:C3747_22g1866c; -.
DR   VEuPathDB; TriTrypDB:C3747_22g1867c; -.
DR   VEuPathDB; TriTrypDB:C3747_22g1868c; -.
DR   VEuPathDB; TriTrypDB:C3747_22g1869c; -.
DR   VEuPathDB; TriTrypDB:C3747_22g1870c; -.
DR   VEuPathDB; TriTrypDB:C3747_22g1871c; -.
DR   VEuPathDB; TriTrypDB:C3747_22g1872c; -.
DR   VEuPathDB; TriTrypDB:C3747_22g1873c; -.
DR   VEuPathDB; TriTrypDB:C3747_22g1874c; -.
DR   VEuPathDB; TriTrypDB:C3747_22g1875c; -.
DR   VEuPathDB; TriTrypDB:C3747_22g1876c; -.
DR   VEuPathDB; TriTrypDB:C3747_22g1878c; -.
DR   VEuPathDB; TriTrypDB:C3747_259g205c; -.
DR   VEuPathDB; TriTrypDB:C4B63_242g10; -.
DR   VEuPathDB; TriTrypDB:Tc_MARK_125; -.
DR   VEuPathDB; TriTrypDB:TcBrA4_0093800; -.
DR   VEuPathDB; TriTrypDB:TcCL_NonESM00496; -.
DR   VEuPathDB; TriTrypDB:TcCLB.508321.21; -.
DR   VEuPathDB; TriTrypDB:TcCLB.511817.151; -.
DR   VEuPathDB; TriTrypDB:TcG_03831; -.
DR   VEuPathDB; TriTrypDB:TcYC6_0092810; -.
DR   VEuPathDB; TriTrypDB:TcYC6_0092820; -.
DR   VEuPathDB; TriTrypDB:TcYC6_0092830; -.
DR   VEuPathDB; TriTrypDB:TcYC6_0092840; -.
DR   VEuPathDB; TriTrypDB:TcYC6_0092850; -.
DR   VEuPathDB; TriTrypDB:TcYC6_0092860; -.
DR   VEuPathDB; TriTrypDB:TcYC6_0092870; -.
DR   VEuPathDB; TriTrypDB:TcYC6_0092880; -.
DR   VEuPathDB; TriTrypDB:TcYC6_0092890; -.
DR   VEuPathDB; TriTrypDB:TcYC6_0092900; -.
DR   VEuPathDB; TriTrypDB:TcYC6_0092910; -.
DR   VEuPathDB; TriTrypDB:TcYC6_0092920; -.
DR   VEuPathDB; TriTrypDB:TcYC6_0092930; -.
DR   VEuPathDB; TriTrypDB:TcYC6_0092940; -.
DR   VEuPathDB; TriTrypDB:TcYC6_0092950; -.
DR   GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   CDD; cd00074; H2A; 1.
DR   Gene3D; 1.10.20.10; -; 1.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR002119; Histone_H2A.
DR   InterPro; IPR007125; Histone_H2A/H2B/H3.
DR   InterPro; IPR032454; Histone_H2A_C.
DR   InterPro; IPR032458; Histone_H2A_CS.
DR   PANTHER; PTHR23430; PTHR23430; 1.
DR   Pfam; PF00125; Histone; 1.
DR   Pfam; PF16211; Histone_H2A_C; 1.
DR   PRINTS; PR00620; HISTONEH2A.
DR   SMART; SM00414; H2A; 1.
DR   SUPFAM; SSF47113; SSF47113; 1.
DR   PROSITE; PS00046; HISTONE_H2A; 1.
PE   3: Inferred from homology;
KW   Chromosome; DNA-binding; Nucleosome core; Nucleus.
FT   CHAIN           1..135
FT                   /note="Histone H2A"
FT                   /id="PRO_0000055287"
SQ   SEQUENCE   135 AA;  14366 MW;  DC41BCE5983EA93B CRC64;
     MATPKQAAKK ASKKRSGGRS AKAGLIFPVG RVGSLLRRGQ YARRIGASGA VYMAAVLEYL
     TAELLELSVK AASQQAKKPK RLTPRTVTLA VRHDDDLGML LKDVTLSRGG VMPSLNKALA
     KKHKSSKKAR ATPSA