H2B11_XENLA
ID H2B11_XENLA Reviewed; 126 AA.
AC P02281; Q6AZT0;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Histone H2B 1.1;
DE Short=H2B1.1;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (GENE CLUSTER X1H3).
RX PubMed=3863963; DOI=10.1016/0022-2836(85)90065-8;
RA Perry M., Thomsen G.H., Roeder R.G.;
RT "Genomic organization and nucleotide sequence of two distinct histone gene
RT clusters from Xenopus laevis. Identification of novel conserved upstream
RT sequence elements.";
RL J. Mol. Biol. 185:479-499(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP PROTEIN SEQUENCE OF 2-30 AND 63-85.
RC TISSUE=Erythrocyte;
RX PubMed=638193; DOI=10.1016/0005-2795(78)90572-x;
RA van Helden P., Strickland W.N., Brandt W.F., von Holt C.;
RT "Histone H2B variants from the erythrocytes of an amphibian, a reptile and
RT a bird.";
RL Biochim. Biophys. Acta 533:278-281(1978).
RN [4]
RP PHOSPHORYLATION AT SER-15.
RX PubMed=12757711; DOI=10.1016/s0092-8674(03)00355-6;
RA Cheung W.L., Ajiro K., Samejima K., Kloc M., Cheung P., Mizzen C.A.,
RA Beeser A., Etkin L.D., Chernoff J., Earnshaw W.C., Allis C.D.;
RT "Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile
RT twenty kinase.";
RL Cell 113:507-517(2003).
RN [5]
RP X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF NUCLEOSOME CORE COMPLEX, AND
RP SUBUNIT.
RX PubMed=9305837; DOI=10.1038/38444;
RA Luger K., Mader A.W., Richmond R.K., Sargent D.F., Richmond T.J.;
RT "Crystal structure of the nucleosome core particle at 2.8 A resolution.";
RL Nature 389:251-260(1997).
RN [6]
RP X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF NUCLEOSOME CORE COMPLEX, AND
RP SUBUNIT.
RX PubMed=12559907; DOI=10.1016/s0022-2836(02)01407-9;
RA Suto R.K., Edayathumangalam R.S., White C.L., Melander C., Gottesfeld J.M.,
RA Dervan P.B., Luger K.;
RT "Crystal structures of nucleosome core particles in complex with minor
RT groove DNA-binding ligands.";
RL J. Mol. Biol. 326:371-380(2003).
RN [7]
RP X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF NUCLEOSOME CORE COMPLEX, AND
RP SUBUNIT.
RX PubMed=14739929; DOI=10.1038/sj.emboj.7600046;
RA Muthurajan U.M., Bao Y., Forsberg L.J., Edayathumangalam R.S., Dyer P.N.,
RA White C.L., Luger K.;
RT "Crystal structures of histone Sin mutant nucleosomes reveal altered
RT protein-DNA interactions.";
RL EMBO J. 23:260-271(2004).
RN [8] {ECO:0007744|PDB:6N1Z}
RP X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 5-126.
RX PubMed=30855230; DOI=10.7554/elife.43630;
RA Padavannil A., Sarkar P., Kim S.J., Cagatay T., Jiou J., Brautigam C.A.,
RA Tomchick D.R., Sali A., D'Arcy S., Chook Y.M.;
RT "Importin-9 wraps around the H2A-H2B core to act as nuclear importer and
RT histone chaperone.";
RL Elife 8:0-0(2019).
RN [9] {ECO:0007744|PDB:6WZ5, ECO:0007744|PDB:6WZ9, ECO:0007744|PDB:6X0N}
RP STRUCTURE BY ELECTRON MICROSCOPY (2.20 ANGSTROMS) OF 5-126 OF NUCLEOSOME
RP CORE COMPLEX IN COMPLEX WITH PARP2 AND HPF1.
RX PubMed=32939087; DOI=10.1038/s41586-020-2725-7;
RA Bilokapic S., Suskiewicz M.J., Ahel I., Halic M.;
RT "Bridging of DNA breaks activates PARP2-HPF1 to modify chromatin.";
RL Nature 585:609-613(2020).
CC -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC DNA into chromatin, limiting DNA accessibility to the cellular
CC machineries which require DNA as a template. Histones thereby play a
CC central role in transcription regulation, DNA repair, DNA replication
CC and chromosomal stability. DNA accessibility is regulated via a complex
CC set of post-translational modifications of histones, also called
CC histone code, and nucleosome remodeling.
CC -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC DNA. {ECO:0000269|PubMed:12559907, ECO:0000269|PubMed:14739929,
CC ECO:0000269|PubMed:9305837}.
CC -!- INTERACTION:
CC P02281; P18754: RCC1; Xeno; NbExp=2; IntAct=EBI-1251201, EBI-992720;
CC -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC -!- PTM: Monoubiquitination of Lys-121 by BRE1 gives a specific tag for
CC epigenetic transcriptional activation and is also prerequisite for
CC histone H3 'Lys-4' and 'Lys-79' methylation.
CC {ECO:0000250|UniProtKB:P33778}.
CC -!- PTM: Phosphorylated on Ser-15 during developmentally programmed
CC apoptosis; which may facilitate apoptotic chromatin condensation.
CC {ECO:0000269|PubMed:12757711}.
CC -!- PTM: GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121.
CC It fluctuates in response to extracellular glucose, and associates with
CC transcribed genes (By similarity). {ECO:0000250|UniProtKB:P62807}.
CC -!- SIMILARITY: Belongs to the histone H2B family. {ECO:0000305}.
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DR EMBL; X03018; CAA26816.1; -; Genomic_DNA.
DR EMBL; M21287; AAA49768.1; -; Genomic_DNA.
DR EMBL; BC077399; AAH77399.1; -; mRNA.
DR PIR; B92918; HSXLB1.
DR RefSeq; NP_001086753.1; NM_001093284.1.
DR PDB; 1AOI; X-ray; 2.80 A; D/H=28-126.
DR PDB; 1F66; X-ray; 2.60 A; D/H=1-126.
DR PDB; 1KX3; X-ray; 2.00 A; D/H=2-126.
DR PDB; 1KX4; X-ray; 2.60 A; D/H=2-126.
DR PDB; 1KX5; X-ray; 1.94 A; D/H=2-126.
DR PDB; 1M18; X-ray; 2.45 A; D/H=2-126.
DR PDB; 1M19; X-ray; 2.30 A; D/H=2-126.
DR PDB; 1M1A; X-ray; 2.65 A; D/H=2-126.
DR PDB; 1P34; X-ray; 2.70 A; D/H=2-126.
DR PDB; 1P3A; X-ray; 3.00 A; D/H=2-126.
DR PDB; 1P3B; X-ray; 3.00 A; D/H=2-126.
DR PDB; 1P3F; X-ray; 2.90 A; D/H=2-126.
DR PDB; 1P3G; X-ray; 2.70 A; D/H=2-126.
DR PDB; 1P3I; X-ray; 2.30 A; D/H=2-126.
DR PDB; 1P3K; X-ray; 2.90 A; D/H=2-126.
DR PDB; 1P3L; X-ray; 2.40 A; D/H=2-126.
DR PDB; 1P3M; X-ray; 2.90 A; D/H=2-126.
DR PDB; 1P3O; X-ray; 2.75 A; D/H=2-126.
DR PDB; 1P3P; X-ray; 2.70 A; D/H=2-126.
DR PDB; 1S32; X-ray; 2.05 A; D/H=5-126.
DR PDB; 1ZBB; X-ray; 9.00 A; D/H/d/h=2-126.
DR PDB; 1ZLA; X-ray; 2.90 A; D/H=2-126.
DR PDB; 2F8N; X-ray; 2.90 A; H=5-126.
DR PDB; 2FJ7; X-ray; 3.20 A; D/H=2-126.
DR PDB; 2NZD; X-ray; 2.65 A; D/H=2-126.
DR PDB; 3B6F; X-ray; 3.45 A; D/H=2-126.
DR PDB; 3B6G; X-ray; 3.45 A; D/H=2-126.
DR PDB; 3KUY; X-ray; 2.90 A; D/H=2-126.
DR PDB; 3KWQ; X-ray; 3.50 A; D/H=34-126.
DR PDB; 3KXB; X-ray; 3.20 A; D/H=5-126.
DR PDB; 3LEL; X-ray; 2.95 A; D/H/N/R=2-126.
DR PDB; 3LJA; X-ray; 2.75 A; D/H=5-126.
DR PDB; 3LZ0; X-ray; 2.50 A; D/H=2-126.
DR PDB; 3LZ1; X-ray; 2.50 A; D/H=2-126.
DR PDB; 3MGP; X-ray; 2.44 A; D/H=2-126.
DR PDB; 3MGQ; X-ray; 2.65 A; D/H=2-126.
DR PDB; 3MGR; X-ray; 2.30 A; D/H=2-126.
DR PDB; 3MGS; X-ray; 3.15 A; D/H=2-126.
DR PDB; 3MNN; X-ray; 2.50 A; D/H=2-126.
DR PDB; 3MVD; X-ray; 2.90 A; D/H=5-126.
DR PDB; 3O62; X-ray; 3.22 A; D/H=5-126.
DR PDB; 3REH; X-ray; 2.50 A; D/H=5-126.
DR PDB; 3REI; X-ray; 2.65 A; D/H=5-126.
DR PDB; 3REJ; X-ray; 2.55 A; D/H=5-126.
DR PDB; 3REK; X-ray; 2.60 A; D/H=5-126.
DR PDB; 3REL; X-ray; 2.70 A; D/H=5-126.
DR PDB; 3TU4; X-ray; 3.00 A; D/H=5-126.
DR PDB; 3UT9; X-ray; 2.20 A; D/H=2-126.
DR PDB; 3UTA; X-ray; 2.07 A; D/H=2-126.
DR PDB; 3UTB; X-ray; 2.20 A; D/H=2-126.
DR PDB; 4J8U; X-ray; 2.38 A; D/H=2-126.
DR PDB; 4J8V; X-ray; 2.58 A; D/H=2-126.
DR PDB; 4J8W; X-ray; 2.41 A; D/H=2-126.
DR PDB; 4J8X; X-ray; 2.87 A; D/H=2-126.
DR PDB; 4KGC; X-ray; 2.69 A; D/H=1-126.
DR PDB; 4KHA; X-ray; 2.35 A; A=34-126.
DR PDB; 4LD9; X-ray; 3.31 A; D/H=1-126.
DR PDB; 4R8P; X-ray; 3.28 A; D/H=5-126.
DR PDB; 4WU8; X-ray; 2.45 A; D/H=2-126.
DR PDB; 4WU9; X-ray; 2.60 A; D/H=2-126.
DR PDB; 4XUJ; X-ray; 3.18 A; D/H=2-126.
DR PDB; 4XZQ; X-ray; 2.40 A; D/H=34-126.
DR PDB; 4YS3; X-ray; 3.00 A; D/H=34-126.
DR PDB; 4Z66; X-ray; 2.50 A; D/H=34-126.
DR PDB; 4ZUX; X-ray; 3.82 A; D/H/N/R=5-126.
DR PDB; 5CP6; X-ray; 2.60 A; D/H=2-126.
DR PDB; 5DNM; X-ray; 2.81 A; D/H=2-126.
DR PDB; 5DNN; X-ray; 2.80 A; D/H=2-126.
DR PDB; 5E5A; X-ray; 2.81 A; D/H=5-126.
DR PDB; 5F99; X-ray; 2.63 A; D/H=5-126.
DR PDB; 5G2E; X-ray; 6.70 A; D/H/L/P/T/X=28-126.
DR PDB; 5HQ2; X-ray; 4.50 A; H=5-126.
DR PDB; 5NL0; X-ray; 5.40 A; D/H/N=5-126.
DR PDB; 5O9G; EM; 4.80 A; D=5-126, H=5-125.
DR PDB; 5OMX; X-ray; 2.32 A; D/H=5-126.
DR PDB; 5ONG; X-ray; 2.80 A; D/H=5-126.
DR PDB; 5ONW; X-ray; 2.80 A; D/H=5-126.
DR PDB; 5OXV; X-ray; 6.72 A; D/H/N/R=1-126.
DR PDB; 5OY7; X-ray; 5.77 A; D/H/L/P/T/X/b/f=1-126.
DR PDB; 5X0X; EM; 3.97 A; D/H=2-126.
DR PDB; 5X0Y; EM; 3.97 A; D/H=5-126.
DR PDB; 5XF6; X-ray; 2.63 A; D/H=2-126.
DR PDB; 5Z3L; EM; 4.31 A; D/H=5-126.
DR PDB; 5Z3O; EM; 3.62 A; D/H=5-126.
DR PDB; 5Z3U; EM; 4.31 A; D/H=5-126.
DR PDB; 5Z3V; EM; 4.22 A; D/H=5-126.
DR PDB; 6ESF; EM; 3.70 A; D/H=5-126.
DR PDB; 6ESG; EM; 5.40 A; D/H=5-126.
DR PDB; 6ESH; EM; 5.10 A; D/H=5-126.
DR PDB; 6ESI; EM; 6.30 A; D/H=5-126.
DR PDB; 6FQ5; EM; 3.80 A; D/H=31-125.
DR PDB; 6FQ6; EM; 4.00 A; D/H=31-125.
DR PDB; 6FQ8; EM; 4.80 A; D/H=31-125.
DR PDB; 6I84; EM; 4.40 A; R/W=5-126.
DR PDB; 6IRO; EM; 3.40 A; D/H=5-126.
DR PDB; 6IY2; EM; 3.47 A; D/H=27-126.
DR PDB; 6IY3; EM; 3.67 A; D/H=29-126.
DR PDB; 6J99; EM; 4.10 A; D/H=5-126.
DR PDB; 6JM9; EM; 7.30 A; D/H=34-126.
DR PDB; 6JMA; EM; 6.80 A; D/H=34-126.
DR PDB; 6JYL; EM; 3.37 A; D/H=5-126.
DR PDB; 6K01; X-ray; 2.84 A; D=28-126.
DR PDB; 6K1P; EM; 3.87 A; D/H=5-126.
DR PDB; 6KIU; EM; 3.20 A; D/H=5-126.
DR PDB; 6KIV; EM; 4.00 A; D/H=5-126.
DR PDB; 6KIW; EM; 4.00 A; D/H=5-126.
DR PDB; 6KIX; EM; 4.10 A; D/H=5-126.
DR PDB; 6KIZ; EM; 4.50 A; D/H=5-126.
DR PDB; 6KW3; EM; 7.13 A; P/T=1-126.
DR PDB; 6KW4; EM; 7.55 A; P/T=1-126.
DR PDB; 6LTJ; EM; 3.70 A; D/H=1-126.
DR PDB; 6N1Z; X-ray; 2.70 A; C/F=5-126.
DR PDB; 6NJ9; EM; 2.96 A; D/H=5-126.
DR PDB; 6NN6; EM; 3.90 A; D/H=5-126.
DR PDB; 6NOG; EM; 3.90 A; D/H=5-126.
DR PDB; 6NQA; EM; 3.54 A; D/H=5-126.
DR PDB; 6NZO; EM; 3.80 A; D/H=5-126.
DR PDB; 6O96; EM; 3.50 A; D/H=5-126.
DR PDB; 6OM3; X-ray; 3.30 A; D/H/P/T=1-126.
DR PDB; 6PA7; EM; 2.94 A; D/H=5-126.
DR PDB; 6PWV; EM; 6.20 A; J/N=5-126.
DR PDB; 6PWW; EM; 4.40 A; J/N=5-126.
DR PDB; 6PWX; EM; 4.20 A; J/N=5-126.
DR PDB; 6PX1; EM; 3.30 A; D/H=5-126.
DR PDB; 6PX3; EM; 4.10 A; D/H=5-126.
DR PDB; 6R1T; EM; 3.70 A; D/H=30-125.
DR PDB; 6R1U; EM; 4.36 A; D/H=5-126.
DR PDB; 6R25; EM; 4.61 A; D/H=1-126.
DR PDB; 6RYR; EM; 3.10 A; D/H=5-126.
DR PDB; 6RYU; EM; 4.00 A; D/H=5-126.
DR PDB; 6S01; EM; 3.20 A; D/H=5-126.
DR PDB; 6T9L; EM; 3.60 A; D=5-126.
DR PDB; 6TDA; EM; 15.00 A; D/H=5-126.
DR PDB; 6TEM; EM; 3.90 A; D/H=2-126.
DR PDB; 6UGM; EM; 3.70 A; H=2-126.
DR PDB; 6UH5; EM; 3.50 A; D/H=2-126.
DR PDB; 6UXW; EM; 8.96 A; U/Y=5-126.
DR PDB; 6VEN; EM; 3.37 A; D/H=5-126.
DR PDB; 6VYP; X-ray; 4.99 A; D/H/d/h=5-126.
DR PDB; 6VZ4; EM; 3.90 A; D/H=1-125.
DR PDB; 6W4L; X-ray; 1.31 A; A=34-126.
DR PDB; 6W5I; EM; 6.90 A; J/N=5-126.
DR PDB; 6W5M; EM; 4.60 A; J/N=5-126.
DR PDB; 6W5N; EM; 6.00 A; J/N=5-126.
DR PDB; 6WKR; EM; 3.50 A; M/S=1-126.
DR PDB; 6WZ5; EM; 2.20 A; D/H=5-126.
DR PDB; 6WZ9; EM; 2.80 A; D/H=5-126.
DR PDB; 6X0N; EM; 10.00 A; D/H/d/h=5-126.
DR PDB; 6ZHX; EM; 2.50 A; D/H=5-126.
DR PDB; 6ZHY; EM; 3.00 A; D=5-126.
DR PDB; 7AT8; EM; 4.40 A; G/K=5-126.
DR PDB; 7CRO; EM; 3.75 A; D/H=5-126.
DR PDB; 7CRP; EM; 3.20 A; D/H=5-126.
DR PDB; 7CRQ; EM; 3.15 A; D/H=5-126.
DR PDB; 7CRR; EM; 3.48 A; D/H=5-126.
DR PDB; 7E8I; EM; 3.10 A; D/H=5-126.
DR PDB; 7EA5; EM; 3.30 A; D/H=32-124.
DR PDB; 7EG6; EM; 3.10 A; D/H=5-126.
DR PDB; 7EGP; EM; 6.90 A; R/V=5-126.
DR PDB; 7ENN; EM; 2.80 A; D/H=5-126.
DR PDB; 7K6P; EM; 3.20 A; D/H=33-125.
DR PDB; 7K6Q; EM; 3.10 A; D/H=33-125.
DR PDB; 7KBD; EM; 3.38 A; D/H=1-126.
DR PDB; 7KBE; EM; 3.50 A; D/H=1-126.
DR PDB; 7KBF; EM; 4.42 A; D/H=1-126.
DR PDB; 7KTQ; EM; 3.30 A; D/H=32-126.
DR PDB; 7M1X; EM; 3.70 A; D/H=1-126.
DR PDB; 7MBM; EM; -; J/N=5-126.
DR PDB; 7MBN; EM; -; J/N=5-126.
DR PDB; 7NKX; EM; 2.90 A; d/h=5-126.
DR PDB; 7NKY; EM; 3.20 A; d/h=5-126.
DR PDB; 7OH9; EM; 3.00 A; D/H=5-126.
DR PDB; 7OHA; EM; 2.90 A; D/H=5-126.
DR PDB; 7OHB; EM; 3.40 A; D/H=5-126.
DR PDB; 7OHC; EM; 2.50 A; D/H=5-126.
DR PDB; 7OTQ; EM; 4.80 A; D/H=5-126.
DR PDBsum; 1AOI; -.
DR PDBsum; 1F66; -.
DR PDBsum; 1KX3; -.
DR PDBsum; 1KX4; -.
DR PDBsum; 1KX5; -.
DR PDBsum; 1M18; -.
DR PDBsum; 1M19; -.
DR PDBsum; 1M1A; -.
DR PDBsum; 1P34; -.
DR PDBsum; 1P3A; -.
DR PDBsum; 1P3B; -.
DR PDBsum; 1P3F; -.
DR PDBsum; 1P3G; -.
DR PDBsum; 1P3I; -.
DR PDBsum; 1P3K; -.
DR PDBsum; 1P3L; -.
DR PDBsum; 1P3M; -.
DR PDBsum; 1P3O; -.
DR PDBsum; 1P3P; -.
DR PDBsum; 1S32; -.
DR PDBsum; 1ZBB; -.
DR PDBsum; 1ZLA; -.
DR PDBsum; 2F8N; -.
DR PDBsum; 2FJ7; -.
DR PDBsum; 2NZD; -.
DR PDBsum; 3B6F; -.
DR PDBsum; 3B6G; -.
DR PDBsum; 3KUY; -.
DR PDBsum; 3KWQ; -.
DR PDBsum; 3KXB; -.
DR PDBsum; 3LEL; -.
DR PDBsum; 3LJA; -.
DR PDBsum; 3LZ0; -.
DR PDBsum; 3LZ1; -.
DR PDBsum; 3MGP; -.
DR PDBsum; 3MGQ; -.
DR PDBsum; 3MGR; -.
DR PDBsum; 3MGS; -.
DR PDBsum; 3MNN; -.
DR PDBsum; 3MVD; -.
DR PDBsum; 3O62; -.
DR PDBsum; 3REH; -.
DR PDBsum; 3REI; -.
DR PDBsum; 3REJ; -.
DR PDBsum; 3REK; -.
DR PDBsum; 3REL; -.
DR PDBsum; 3TU4; -.
DR PDBsum; 3UT9; -.
DR PDBsum; 3UTA; -.
DR PDBsum; 3UTB; -.
DR PDBsum; 4J8U; -.
DR PDBsum; 4J8V; -.
DR PDBsum; 4J8W; -.
DR PDBsum; 4J8X; -.
DR PDBsum; 4KGC; -.
DR PDBsum; 4KHA; -.
DR PDBsum; 4LD9; -.
DR PDBsum; 4R8P; -.
DR PDBsum; 4WU8; -.
DR PDBsum; 4WU9; -.
DR PDBsum; 4XUJ; -.
DR PDBsum; 4XZQ; -.
DR PDBsum; 4YS3; -.
DR PDBsum; 4Z66; -.
DR PDBsum; 4ZUX; -.
DR PDBsum; 5CP6; -.
DR PDBsum; 5DNM; -.
DR PDBsum; 5DNN; -.
DR PDBsum; 5E5A; -.
DR PDBsum; 5F99; -.
DR PDBsum; 5G2E; -.
DR PDBsum; 5HQ2; -.
DR PDBsum; 5NL0; -.
DR PDBsum; 5O9G; -.
DR PDBsum; 5OMX; -.
DR PDBsum; 5ONG; -.
DR PDBsum; 5ONW; -.
DR PDBsum; 5OXV; -.
DR PDBsum; 5OY7; -.
DR PDBsum; 5X0X; -.
DR PDBsum; 5X0Y; -.
DR PDBsum; 5XF6; -.
DR PDBsum; 5Z3L; -.
DR PDBsum; 5Z3O; -.
DR PDBsum; 5Z3U; -.
DR PDBsum; 5Z3V; -.
DR PDBsum; 6ESF; -.
DR PDBsum; 6ESG; -.
DR PDBsum; 6ESH; -.
DR PDBsum; 6ESI; -.
DR PDBsum; 6FQ5; -.
DR PDBsum; 6FQ6; -.
DR PDBsum; 6FQ8; -.
DR PDBsum; 6I84; -.
DR PDBsum; 6IRO; -.
DR PDBsum; 6IY2; -.
DR PDBsum; 6IY3; -.
DR PDBsum; 6J99; -.
DR PDBsum; 6JM9; -.
DR PDBsum; 6JMA; -.
DR PDBsum; 6JYL; -.
DR PDBsum; 6K01; -.
DR PDBsum; 6K1P; -.
DR PDBsum; 6KIU; -.
DR PDBsum; 6KIV; -.
DR PDBsum; 6KIW; -.
DR PDBsum; 6KIX; -.
DR PDBsum; 6KIZ; -.
DR PDBsum; 6KW3; -.
DR PDBsum; 6KW4; -.
DR PDBsum; 6LTJ; -.
DR PDBsum; 6N1Z; -.
DR PDBsum; 6NJ9; -.
DR PDBsum; 6NN6; -.
DR PDBsum; 6NOG; -.
DR PDBsum; 6NQA; -.
DR PDBsum; 6NZO; -.
DR PDBsum; 6O96; -.
DR PDBsum; 6OM3; -.
DR PDBsum; 6PA7; -.
DR PDBsum; 6PWV; -.
DR PDBsum; 6PWW; -.
DR PDBsum; 6PWX; -.
DR PDBsum; 6PX1; -.
DR PDBsum; 6PX3; -.
DR PDBsum; 6R1T; -.
DR PDBsum; 6R1U; -.
DR PDBsum; 6R25; -.
DR PDBsum; 6RYR; -.
DR PDBsum; 6RYU; -.
DR PDBsum; 6S01; -.
DR PDBsum; 6T9L; -.
DR PDBsum; 6TDA; -.
DR PDBsum; 6TEM; -.
DR PDBsum; 6UGM; -.
DR PDBsum; 6UH5; -.
DR PDBsum; 6UXW; -.
DR PDBsum; 6VEN; -.
DR PDBsum; 6VYP; -.
DR PDBsum; 6VZ4; -.
DR PDBsum; 6W4L; -.
DR PDBsum; 6W5I; -.
DR PDBsum; 6W5M; -.
DR PDBsum; 6W5N; -.
DR PDBsum; 6WKR; -.
DR PDBsum; 6WZ5; -.
DR PDBsum; 6WZ9; -.
DR PDBsum; 6X0N; -.
DR PDBsum; 6ZHX; -.
DR PDBsum; 6ZHY; -.
DR PDBsum; 7AT8; -.
DR PDBsum; 7CRO; -.
DR PDBsum; 7CRP; -.
DR PDBsum; 7CRQ; -.
DR PDBsum; 7CRR; -.
DR PDBsum; 7E8I; -.
DR PDBsum; 7EA5; -.
DR PDBsum; 7EG6; -.
DR PDBsum; 7EGP; -.
DR PDBsum; 7ENN; -.
DR PDBsum; 7K6P; -.
DR PDBsum; 7K6Q; -.
DR PDBsum; 7KBD; -.
DR PDBsum; 7KBE; -.
DR PDBsum; 7KBF; -.
DR PDBsum; 7KTQ; -.
DR PDBsum; 7M1X; -.
DR PDBsum; 7MBM; -.
DR PDBsum; 7MBN; -.
DR PDBsum; 7NKX; -.
DR PDBsum; 7NKY; -.
DR PDBsum; 7OH9; -.
DR PDBsum; 7OHA; -.
DR PDBsum; 7OHB; -.
DR PDBsum; 7OHC; -.
DR PDBsum; 7OTQ; -.
DR AlphaFoldDB; P02281; -.
DR SASBDB; P02281; -.
DR SMR; P02281; -.
DR BioGRID; 103448; 10.
DR DIP; DIP-38577N; -.
DR IntAct; P02281; 11.
DR iPTMnet; P02281; -.
DR DNASU; 446588; -.
DR GeneID; 446588; -.
DR KEGG; xla:446588; -.
DR CTD; 446588; -.
DR Xenbase; XB-GENE-6493994; h2bc11.S.
DR OrthoDB; 1536672at2759; -.
DR EvolutionaryTrace; P02281; -.
DR Proteomes; UP000186698; Chromosome 3S.
DR Bgee; 446588; Expressed in ovary and 13 other tissues.
DR GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR Gene3D; 1.10.20.10; -; 1.
DR IDEAL; IID50135; -.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR007125; Histone_H2A/H2B/H3.
DR InterPro; IPR000558; Histone_H2B.
DR PANTHER; PTHR23428; PTHR23428; 1.
DR Pfam; PF00125; Histone; 1.
DR PRINTS; PR00621; HISTONEH2B.
DR SMART; SM00427; H2B; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
DR PROSITE; PS00357; HISTONE_H2B; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Chromosome; Direct protein sequencing;
KW DNA-binding; Glycoprotein; Isopeptide bond; Nucleosome core; Nucleus;
KW Phosphoprotein; Reference proteome; Ubl conjugation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:638193"
FT CHAIN 2..126
FT /note="Histone H2B 1.1"
FT /id="PRO_0000071854"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..35
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 6
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P0C1H4"
FT MOD_RES 13
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P0C1H4"
FT MOD_RES 15
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:12757711"
FT MOD_RES 16
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P0C1H4"
FT MOD_RES 21
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P0C1H4"
FT CARBOHYD 113
FT /note="O-linked (GlcNAc) serine"
FT /evidence="ECO:0000250|UniProtKB:P62807"
FT CROSSLNK 121
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT /evidence="ECO:0000250|UniProtKB:P0C1H4"
FT STRAND 9..11
FT /evidence="ECO:0007829|PDB:1KX5"
FT STRAND 18..20
FT /evidence="ECO:0007829|PDB:1KX5"
FT HELIX 39..49
FT /evidence="ECO:0007829|PDB:6W4L"
FT HELIX 57..84
FT /evidence="ECO:0007829|PDB:6W4L"
FT STRAND 88..90
FT /evidence="ECO:0007829|PDB:6W4L"
FT HELIX 92..102
FT /evidence="ECO:0007829|PDB:6W4L"
FT HELIX 105..124
FT /evidence="ECO:0007829|PDB:6W4L"
SQ SEQUENCE 126 AA; 13934 MW; DA6C122EC8359FD9 CRC64;
MPEPAKSAPA PKKGSKKAVT KTQKKDGKKR RKSRKESYAI YVYKVLKQVH PDTGISSKAM
SIMNSFVNDV FERIAGEASR LAHYNKRSTI TSREIQTAVR LLLPGELAKH AVSEGTKAVT
KYTSAK
