ID   AMYC_THETU              Reviewed;         274 AA.
AC   P37729; P26828;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Probable starch degradation products transport system permease protein AmyC;
GN   Name=amyC;
OS   Thermoanaerobacterium thermosulfurigenes (Clostridium thermosulfurogenes).
OC   Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacterales Family III. Incertae Sedis; Thermoanaerobacterium.
OX   NCBI_TaxID=33950;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 3896 / EM1;
RX   PubMed=1874408; DOI=10.1016/0378-1097(91)90476-q;
RA   Bahl H., Burchhardt G., Wienecke A.;
RT   "Nucleotide sequence of two Clostridium thermosulfurogenes EM1 genes
RT   homologous to Escherichia coli genes encoding integral membrane components
RT   of binding protein-dependent transport systems.";
RL   FEMS Microbiol. Lett. 65:83-87(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 115-274.
RC   STRAIN=DSM 3896 / EM1;
RX   PubMed=1854207; DOI=10.1128/aem.57.5.1554-1559.1991;
RA   Bahl H., Burchhardt G., Spreinat A., Haeckel K., Wienecke A., Schmidt B.,
RA   Antranikian G.;
RT   "Alpha-amylase of Clostridium thermosulfurogenes EM1: nucleotide sequence
RT   of the gene, processing of the enzyme, and comparison of other alpha-
RT   amylases.";
RL   Appl. Environ. Microbiol. 57:1554-1559(1991).
CC   -!- FUNCTION: Probably part of a binding-protein-dependent transport system
CC       starch degradation products. Probably responsible for the translocation
CC       of the substrate across the membrane.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. MalFG subfamily. {ECO:0000305}.
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DR   EMBL; M57692; AAB00844.1; -; Genomic_DNA.
DR   PIR; S37705; S37705.
DR   AlphaFoldDB; P37729; -.
DR   SMR; P37729; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   CDD; cd06261; TM_PBP2; 1.
DR   Gene3D; 1.10.3720.10; -; 1.
DR   InterPro; IPR000515; MetI-like.
DR   InterPro; IPR035906; MetI-like_sf.
DR   Pfam; PF00528; BPD_transp_1; 1.
DR   SUPFAM; SSF161098; SSF161098; 1.
DR   PROSITE; PS50928; ABC_TM1; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..274
FT                   /note="Probable starch degradation products transport
FT                   system permease protein AmyC"
FT                   /id="PRO_0000059947"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        238..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   DOMAIN          69..259
FT                   /note="ABC transmembrane type-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   CONFLICT        115..155
FT                   /note="IPFQSVMIPLVAEFGKFHFLTRSGLVFMYLGFGSSLGVFLY -> DPVSISY
FT                   DSISSGIWEISFSYKVRACIYVLGIWFKLRSVFIL (in Ref. 2)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   274 AA;  30994 MW;  5921E22D0A4B8819 CRC64;
     MRKVHVQKYL LTFLGIVLSL LWISPFYIIL VNSFKTKLEL FTNTLSLPKS LMLDNYKTAA
     ANLNLSEAFS NTLIITVFSI LIIAIFSSMT AYALQRVKRK SSVIIYMIFT VAMLIPFQSV
     MIPLVAEFGK FHFLTRSGLV FMYLGFGSSL GVFLYYGALK GIPTSLDEAA LIDGCSRFRI
     YWNIILPLLN PTTITLAVLD IMWIWNDYLL PSLVINKVGS RTLPLMIFYF FSQYTKQWNL
     GMAGLTIAIL PVVIFYFLAQ RKLVTAIIAG AVKQ