H2BL1_MOUSE
ID H2BL1_MOUSE Reviewed; 123 AA.
AC Q9D9Z7;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Histone H2B variant L1 {ECO:0000303|PubMed:17261847};
DE AltName: Full=Histone H2B subacrosomal variant {ECO:0000303|PubMed:11784042};
GN Name=H2bl1 {ECO:0000303|PubMed:17261847, ECO:0000312|MGI:MGI:1916632};
GN Synonyms=SubH2Bv {ECO:0000303|PubMed:11784042};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=11784042; DOI=10.1006/dbio.2001.0427;
RA Aul R.B., Oko R.J.;
RT "The major subacrosomal occupant of bull spermatozoa is a novel histone H2B
RT variant associated with the forming acrosome during spermiogenesis.";
RL Dev. Biol. 239:376-387(2001).
RN [4]
RP ERRATUM OF PUBMED:11784042.
RX PubMed=11892742; DOI=10.1006/dbio.2002.0575;
RA Aul R.B., Oko R.J.;
RL Dev. Biol. 242:376-387(2002).
RN [5]
RP TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RX PubMed=17261847; DOI=10.1083/jcb.200604141;
RA Govin J., Escoffier E., Rousseaux S., Kuhn L., Ferro M., Thevenon J.,
RA Catena R., Davidson I., Garin J., Khochbin S., Caron C.;
RT "Pericentric heterochromatin reprogramming by new histone variants during
RT mouse spermiogenesis.";
RL J. Cell Biol. 176:283-294(2007).
CC -!- FUNCTION: May act as an acrosome-nuclear docking protein in sperm.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Subacrosomal
CC region. Does not localize in nucleus (By similarity). {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Present in testis (at protein level)
CC (PubMed:11784042, PubMed:17261847). Not detected in other tissues
CC tested (PubMed:17261847). {ECO:0000269|PubMed:11784042,
CC ECO:0000269|PubMed:17261847}.
CC -!- DEVELOPMENTAL STAGE: Highly expressed during late spermiogenesis, in
CC condensing spermatids (at protein level). Expression persists in mature
CC spermatozoa (at protein level). Expression is first detected from the
CC round spermatid stage and increases thereafter.
CC {ECO:0000269|PubMed:17261847}.
CC -!- SIMILARITY: Belongs to the histone H2B family. {ECO:0000305}.
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DR EMBL; AK006311; BAB24520.1; -; mRNA.
DR EMBL; AC154849; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS49342.1; -.
DR RefSeq; NP_081340.1; NM_027064.1.
DR AlphaFoldDB; Q9D9Z7; -.
DR SMR; Q9D9Z7; -.
DR STRING; 10090.ENSMUSP00000053046; -.
DR iPTMnet; Q9D9Z7; -.
DR PhosphoSitePlus; Q9D9Z7; -.
DR PaxDb; Q9D9Z7; -.
DR PRIDE; Q9D9Z7; -.
DR ProteomicsDB; 271125; -.
DR Ensembl; ENSMUST00000054425; ENSMUSP00000053046; ENSMUSG00000045022.
DR GeneID; 69382; -.
DR KEGG; mmu:69382; -.
DR UCSC; uc011zdm.1; mouse.
DR CTD; 69382; -.
DR MGI; MGI:1916632; H2bl1.
DR VEuPathDB; HostDB:ENSMUSG00000045022; -.
DR eggNOG; KOG1744; Eukaryota.
DR GeneTree; ENSGT01050000244943; -.
DR HOGENOM; CLU_075666_2_2_1; -.
DR InParanoid; Q9D9Z7; -.
DR OMA; EAHHLMC; -.
DR OrthoDB; 1536672at2759; -.
DR PhylomeDB; Q9D9Z7; -.
DR TreeFam; TF300212; -.
DR BioGRID-ORCS; 69382; 0 hits in 72 CRISPR screens.
DR PRO; PR:Q9D9Z7; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q9D9Z7; protein.
DR Bgee; ENSMUSG00000045022; Expressed in seminiferous tubule of testis and 21 other tissues.
DR Genevisible; Q9D9Z7; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0006334; P:nucleosome assembly; IBA:GO_Central.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR007125; Histone_H2A/H2B/H3.
DR InterPro; IPR000558; Histone_H2B.
DR PANTHER; PTHR23428; PTHR23428; 1.
DR Pfam; PF00125; Histone; 1.
DR PRINTS; PR00621; HISTONEH2B.
DR SMART; SM00427; H2B; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Reference proteome.
FT CHAIN 1..123
FT /note="Histone H2B variant L1"
FT /id="PRO_0000244839"
SQ SEQUENCE 123 AA; 14197 MW; 45A1C0B6C464A570 CRC64;
MAKPTFKRQC YIKRHLRPLY RKHSRCSSIN LGHGNYSLYI NRVLKEVVPN RGISSYSVDI
MNILINDIFE RIATEACQQM FLRKRCTLTP GDIQQAVHLL LPKKLATLAV TFGSKAVHRF
IHS
