ID   H2BV1_DICDI             Reviewed;         226 AA.
AC   Q54BC2;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Histone H2B.v1;
GN   Name=H2Bv1; ORFNames=DDB_G0293758;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SIMILARITY: Belongs to the histone H2B family. {ECO:0000305}.
CC   -!- CAUTION: In contrast to other members of the histone H2B family, this
CC       protein is much longer and has a highly divergent N-terminus. It is
CC       therefore unclear whether it is a real histone. {ECO:0000305}.
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DR   EMBL; AAFI02000219; EAL60556.1; -; Genomic_DNA.
DR   RefSeq; XP_628972.1; XM_628970.1.
DR   AlphaFoldDB; Q54BC2; -.
DR   SMR; Q54BC2; -.
DR   STRING; 44689.DDB0216303; -.
DR   PaxDb; Q54BC2; -.
DR   EnsemblProtists; EAL60556; EAL60556; DDB_G0293758.
DR   GeneID; 8629401; -.
DR   KEGG; ddi:DDB_G0293758; -.
DR   dictyBase; DDB_G0293758; H2Bv1.
DR   eggNOG; KOG1744; Eukaryota.
DR   eggNOG; KOG1756; Eukaryota.
DR   HOGENOM; CLU_1226730_0_0_1; -.
DR   InParanoid; Q54BC2; -.
DR   OMA; KVKQMNY; -.
DR   Reactome; R-DDI-2299718; Condensation of Prophase Chromosomes.
DR   Reactome; R-DDI-2559580; Oxidative Stress Induced Senescence.
DR   Reactome; R-DDI-3214815; HDACs deacetylate histones.
DR   Reactome; R-DDI-427359; SIRT1 negatively regulates rRNA expression.
DR   Reactome; R-DDI-5689880; Ub-specific processing proteases.
DR   Reactome; R-DDI-5693565; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
DR   Reactome; R-DDI-68616; Assembly of the ORC complex at the origin of replication.
DR   Reactome; R-DDI-73772; RNA Polymerase I Promoter Escape.
DR   PRO; PR:Q54BC2; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0006334; P:nucleosome assembly; IBA:GO_Central.
DR   Gene3D; 1.10.20.10; -; 1.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR002119; Histone_H2A.
DR   InterPro; IPR007125; Histone_H2A/H2B/H3.
DR   InterPro; IPR000558; Histone_H2B.
DR   PANTHER; PTHR23428; PTHR23428; 1.
DR   Pfam; PF00125; Histone; 2.
DR   PRINTS; PR00621; HISTONEH2B.
DR   SMART; SM00414; H2A; 1.
DR   SMART; SM00427; H2B; 1.
DR   SUPFAM; SSF47113; SSF47113; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..226
FT                   /note="Histone H2B.v1"
FT                   /id="PRO_0000389158"
FT   REGION          100..130
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        105..130
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   226 AA;  25214 MW;  F14D8872E64ACEE3 CRC64;
     MRHRGRRSTQ HTHVREGIYI KKLIKQINPA CRIQVKSVQI LTSLIRDTTI SIMNEAFHLV
     QLSNKRTLSA RDVQTSVRLC TVGEISRHAV SEGVKRVTNF NSAKQYPPQP PPAKTATPSS
     PSSIPAPPIS HPPIIPHSYL KTKVKQMNYN YRISNSSMHY LSAVIEYLLS EILELSSNGA
     VSAKRTLIQP RDIFLAIAND IELHSMYGHV IIPGGGTKPL FNSLSF