H2BV2_DICDI
ID H2BV2_DICDI Reviewed; 474 AA.
AC Q7KWR7; Q551U5;
DT 24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Histone H2B.v2;
GN Name=H2Bv2; ORFNames=DDB_G0276273;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SIMILARITY: Belongs to the histone H2B family. {ECO:0000305}.
CC -!- CAUTION: In contrast to other members of the histone H2B family, this
CC protein is much longer and has a highly divergent N-terminus. It is
CC therefore unclear whether it is a real histone. {ECO:0000305}.
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DR EMBL; AAFI02000014; EAL69283.1; -; Genomic_DNA.
DR RefSeq; XP_643232.1; XM_638140.1.
DR AlphaFoldDB; Q7KWR7; -.
DR STRING; 44689.DDB0216304; -.
DR PaxDb; Q7KWR7; -.
DR PRIDE; Q7KWR7; -.
DR EnsemblProtists; EAL69283; EAL69283; DDB_G0276273.
DR GeneID; 8620436; -.
DR KEGG; ddi:DDB_G0276273; -.
DR dictyBase; DDB_G0276273; H2Bv2.
DR eggNOG; ENOG502REEB; Eukaryota.
DR HOGENOM; CLU_576750_0_0_1; -.
DR InParanoid; Q7KWR7; -.
DR OMA; INQSKGR; -.
DR Reactome; R-DDI-2299718; Condensation of Prophase Chromosomes.
DR Reactome; R-DDI-2559580; Oxidative Stress Induced Senescence.
DR Reactome; R-DDI-3214815; HDACs deacetylate histones.
DR Reactome; R-DDI-427359; SIRT1 negatively regulates rRNA expression.
DR Reactome; R-DDI-5689880; Ub-specific processing proteases.
DR Reactome; R-DDI-5693565; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
DR Reactome; R-DDI-68616; Assembly of the ORC complex at the origin of replication.
DR Reactome; R-DDI-73772; RNA Polymerase I Promoter Escape.
DR PRO; PR:Q7KWR7; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0006334; P:nucleosome assembly; IBA:GO_Central.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR000558; Histone_H2B.
DR PANTHER; PTHR23428; PTHR23428; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
PE 3: Inferred from homology;
KW Reference proteome.
FT CHAIN 1..474
FT /note="Histone H2B.v2"
FT /id="PRO_0000389159"
FT REGION 99..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 276..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 328..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 474 AA; 53730 MW; CDEB27301498E29A CRC64;
MESYSPSIQK LCVFLKPESD ISNTGISYLN NFLADMSNAI IVESIHSSKS HKHKTILIED
IESALNVVFP SEIADSIINQ SKGRIQSTSL KNLMQVKTFN NGGNNNNNNE QDNDLQEKEQ
NELSDDSDVE GFEIIPNNNN IYSHDVSLCF PIDLVCRVTL DYICRKKVIH QNPSDFYKVI
EQQQSNHVIY TYISYALEVI TTKILIKISS STDLIDEDII RKVIQDNHHL NSVRHKNIQA
SNIAGKLLDS SSSSNSNLQT SLSSSFIFSS SSNNTTTFTQ QEQQEQFNDD KISGDEIEFE
INNSKYLEKE DKKDQLIQKD EEIILKTFND NNNNNNNNNN NNNNNNNNNN NNININNDND
NNNNNNKNND NKNYDNNNNN NADKIEKLSP VNNNVKNSEI EKNIEKLKNI NNNNNVEINE
ALISIIKETC KNIPSSSFSS VKNLKRSPPS LFKFKEPIDL VQVLAEGGIH MEAT
