ID   H2BV_BOVIN              Reviewed;         122 AA.
AC   Q8WNR4;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Histone H2B subacrosomal variant;
DE   AltName: Full=SubH2Bv;
GN   Name=SUBH2BV;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-17, FUNCTION, SUBCELLULAR
RP   LOCATION, AND TISSUE SPECIFICITY.
RC   TISSUE=Testis;
RX   PubMed=11784042; DOI=10.1006/dbio.2001.0427;
RA   Aul R.B., Oko R.J.;
RT   "The major subacrosomal occupant of bull spermatozoa is a novel histone H2B
RT   variant associated with the forming acrosome during spermiogenesis.";
RL   Dev. Biol. 239:376-387(2001).
RN   [2]
RP   ERRATUM OF PUBMED:11784042.
RA   Aul R.B., Oko R.J.;
RL   Dev. Biol. 242:376-387(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as an acrosome-nuclear docking protein in sperm.
CC       {ECO:0000269|PubMed:11784042}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11784042}.
CC       Note=Subacrosomal region. Does not localize in nucleus.
CC   -!- TISSUE SPECIFICITY: Testis-specific. Restricted to the spermatid
CC       population of seminiferous epithelium. Not present in Sertoli cells,
CC       spermatogonia, spermatocytes or cells of the interstitial tissue (at
CC       protein level). {ECO:0000269|PubMed:11784042}.
CC   -!- SIMILARITY: Belongs to the histone H2B family. {ECO:0000305}.
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DR   EMBL; AF315690; AAL66185.1; -; mRNA.
DR   EMBL; BC108210; AAI08211.1; -; mRNA.
DR   RefSeq; NP_991343.1; NM_205774.3.
DR   AlphaFoldDB; Q8WNR4; -.
DR   SMR; Q8WNR4; -.
DR   STRING; 9913.ENSBTAP00000016978; -.
DR   PaxDb; Q8WNR4; -.
DR   PRIDE; Q8WNR4; -.
DR   Ensembl; ENSBTAT00000016978; ENSBTAP00000016978; ENSBTAG00000012775.
DR   GeneID; 404073; -.
DR   KEGG; bta:404073; -.
DR   CTD; 69382; -.
DR   VEuPathDB; HostDB:ENSBTAG00000012775; -.
DR   VGNC; VGNC:84128; H2BL1.
DR   eggNOG; KOG1744; Eukaryota.
DR   GeneTree; ENSGT01050000244943; -.
DR   HOGENOM; CLU_075666_2_2_1; -.
DR   InParanoid; Q8WNR4; -.
DR   OMA; EAHHLMC; -.
DR   OrthoDB; 1536672at2759; -.
DR   TreeFam; TF300212; -.
DR   Proteomes; UP000009136; Chromosome 20.
DR   Bgee; ENSBTAG00000012775; Expressed in semen and 17 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0006334; P:nucleosome assembly; IBA:GO_Central.
DR   Gene3D; 1.10.20.10; -; 1.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR007125; Histone_H2A/H2B/H3.
DR   InterPro; IPR000558; Histone_H2B.
DR   PANTHER; PTHR23428; PTHR23428; 1.
DR   Pfam; PF00125; Histone; 1.
DR   PRINTS; PR00621; HISTONEH2B.
DR   SMART; SM00427; H2B; 1.
DR   SUPFAM; SSF47113; SSF47113; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Direct protein sequencing; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:11784042"
FT   CHAIN           2..122
FT                   /note="Histone H2B subacrosomal variant"
FT                   /id="PRO_0000244823"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..21
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   122 AA;  14224 MW;  9149BA61CB85F7B0 CRC64;
     MARNVTKRNK RCRGHQKAIY KKKSHSSSES GLRNYSLYIN RVLKEVVPQK GISSRTIDII
     NTMINDMFER ISTEACNLMY YRKRCTLTPE DIEKAVYLLL PEKLAKYAVA FGKEAVQRYV
     RS