ID   H2B_ACRFO               Reviewed;         125 AA.
AC   P35067;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Histone H2B;
OS   Acropora formosa (Staghorn coral).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Scleractinia;
OC   Astrocoeniina; Acroporidae; Acropora.
OX   NCBI_TaxID=126732;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7901422; DOI=10.1007/bf00175501;
RA   Miller D.J., Harrison P.L., Mahony T.J., McMillan J.P., Miles A.,
RA   Odorico D.M., ten Lohuis M.R.;
RT   "Nucleotide sequence of the histone gene cluster in the coral Acropora
RT   formosa (Cnidaria; Scleractinia): features of histone gene structure and
RT   organization are common to diploblastic and triploblastic metazoans.";
RL   J. Mol. Evol. 37:245-253(1993).
CC   -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC       DNA into chromatin, limiting DNA accessibility to the cellular
CC       machineries which require DNA as a template. Histones thereby play a
CC       central role in transcription regulation, DNA repair, DNA replication
CC       and chromosomal stability. DNA accessibility is regulated via a complex
CC       set of post-translational modifications of histones, also called
CC       histone code, and nucleosome remodeling.
CC   -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC       each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC       two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC       DNA.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC   -!- PTM: Monoubiquitination of Lys-120 gives a specific tag for epigenetic
CC       transcriptional activation and is also prerequisite for histone H3
CC       'Lys-4' and 'Lys-79' methylation. {ECO:0000250}.
CC   -!- PTM: GlcNAcylation at Ser-112 promotes monoubiquitination of Lys-120.
CC       It fluctuates in response to extracellular glucose, and associates with
CC       transcribed genes (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the histone H2B family. {ECO:0000305}.
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DR   EMBL; L11067; AAC37353.1; -; Genomic_DNA.
DR   EMBL; S67324; AAB28737.1; -; Genomic_DNA.
DR   AlphaFoldDB; P35067; -.
DR   SMR; P35067; -.
DR   GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   Gene3D; 1.10.20.10; -; 1.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR007125; Histone_H2A/H2B/H3.
DR   InterPro; IPR000558; Histone_H2B.
DR   PANTHER; PTHR23428; PTHR23428; 1.
DR   Pfam; PF00125; Histone; 1.
DR   PRINTS; PR00621; HISTONEH2B.
DR   SMART; SM00427; H2B; 1.
DR   SUPFAM; SSF47113; SSF47113; 1.
DR   PROSITE; PS00357; HISTONE_H2B; 1.
PE   3: Inferred from homology;
KW   Chromosome; DNA-binding; Glycoprotein; Isopeptide bond; Nucleosome core;
KW   Nucleus; Ubl conjugation.
FT   CHAIN           1..125
FT                   /note="Histone H2B"
FT                   /id="PRO_0000071875"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        112
FT                   /note="O-linked (GlcNAc) serine"
FT                   /evidence="ECO:0000250"
FT   CROSSLNK        120
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in ubiquitin)"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   125 AA;  13814 MW;  6B240F31D0CB8B18 CRC64;
     MAPKVRAAKK GEKRVGKAKS GTAETAKRRR GKRKESYAIY IYKVLKQVHP DTGISSKAMG
     IMNSFVNDIF ERIAVESSRL SLYNKKATIS SREIQTAIRL LLPGELAKHA VSEGTKAVTK
     YTSSK