H2B_DROER
ID H2B_DROER Reviewed; 123 AA.
AC P59781; B3NLS5;
DT 19-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Histone H2B;
GN Name=His2B;
GN and
GN ORFNames=GG10953;
GN and
GN ORFNames=GG11014;
GN and
GN ORFNames=GG11016;
GN and
GN ORFNames=GG11018;
GN and
GN ORFNames=GG11020;
GN and
GN ORFNames=GG11022;
GN and
GN ORFNames=GG12581;
GN and
GN ORFNames=GG12583;
GN and
GN ORFNames=GG12585;
GN and
GN ORFNames=GG12957;
GN and
GN ORFNames=GG13028;
GN and
GN ORFNames=GG13030;
GN and
GN ORFNames=GG13032;
GN and
GN ORFNames=GG13035;
GN and
GN ORFNames=GG13036;
GN and
GN ORFNames=GG13057;
GN and
GN ORFNames=GG13061;
GN and
GN ORFNames=GG16373;
GN and
GN ORFNames=GG18684;
GN and
GN ORFNames=GG19831;
GN and
GN ORFNames=GG19845;
GN and
GN ORFNames=GG19848;
GN and
GN ORFNames=GG21488;
GN and
GN ORFNames=GG21492;
GN and
GN ORFNames=GG21494;
OS Drosophila erecta (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7220;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (HIS2B).
RX PubMed=11922104; DOI=10.1266/ggs.76.355;
RA Tsunemoto K., Matsuo Y.;
RT "Molecular evolutionary analysis of a histone gene repeating unit from
RT Drosophila simulans.";
RL Genes Genet. Syst. 76:355-361(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (GG10953; GG11014; GG11016;
RP GG11018; GG11020; GG11022; GG12581; GG12583; GG12585; GG12957; GG13028;
RP GG13030; GG13032; GG13035; GG13036; GG13057; GG13061; GG16373; GG18684;
RP GG19831; GG19845; GG19848; GG21488; GG21492 AND GG21494).
RC STRAIN=Tucson 14021-0224.01;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC DNA into chromatin, limiting DNA accessibility to the cellular
CC machineries which require DNA as a template. Histones thereby play a
CC central role in transcription regulation, DNA repair, DNA replication
CC and chromosomal stability. DNA accessibility is regulated via a complex
CC set of post-translational modifications of histones, also called
CC histone code, and nucleosome remodeling.
CC -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC DNA.
CC -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC -!- PTM: Monoubiquitination of Lys-118 by Bre1 gives a specific tag for
CC epigenetic transcriptional activation and is also prerequisite for
CC histone H3 'Lys-4' and 'Lys-79' methylation. {ECO:0000250}.
CC -!- PTM: GlcNAcylation at Ser-110 promotes monoubiquitination of Lys-118.
CC It fluctuates in response to extracellular glucose, and associates with
CC transcribed genes (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the histone H2B family. {ECO:0000305}.
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DR EMBL; AB073634; BAC54553.1; -; Genomic_DNA.
DR EMBL; CH954179; EDV54391.1; -; Genomic_DNA.
DR EMBL; CH954179; EDV54396.1; -; Genomic_DNA.
DR EMBL; CH954179; EDV54401.1; -; Genomic_DNA.
DR EMBL; CH954354; EDV45312.1; -; Genomic_DNA.
DR EMBL; CH954354; EDV45317.1; -; Genomic_DNA.
DR EMBL; CH954354; EDV45322.1; -; Genomic_DNA.
DR EMBL; CH954354; EDV45327.1; -; Genomic_DNA.
DR EMBL; CH954357; EDV45119.1; -; Genomic_DNA.
DR EMBL; CH954357; EDV45124.1; -; Genomic_DNA.
DR EMBL; CH954357; EDV45129.1; -; Genomic_DNA.
DR EMBL; CH954357; EDV45134.1; -; Genomic_DNA.
DR EMBL; CH954357; EDV45138.1; -; Genomic_DNA.
DR EMBL; CH954440; EDV45297.1; -; Genomic_DNA.
DR EMBL; CH954440; EDV45302.1; -; Genomic_DNA.
DR EMBL; CH954690; EDV45079.1; -; Genomic_DNA.
DR EMBL; CH954690; EDV45084.1; -; Genomic_DNA.
DR EMBL; CH955154; EDV45332.1; -; Genomic_DNA.
DR EMBL; CH955254; EDV45102.1; -; Genomic_DNA.
DR EMBL; CH955409; EDV45190.1; -; Genomic_DNA.
DR EMBL; CH956753; EDV45076.1; -; Genomic_DNA.
DR EMBL; CH957170; EDV45087.1; -; Genomic_DNA.
DR EMBL; CH958399; EDV45063.1; -; Genomic_DNA.
DR RefSeq; XP_001973991.1; XM_001973955.2.
DR RefSeq; XP_001973996.1; XM_001973960.1.
DR RefSeq; XP_001974001.1; XM_001973965.1.
DR RefSeq; XP_001982891.1; XM_001982855.1.
DR RefSeq; XP_001982896.1; XM_001982860.1.
DR RefSeq; XP_001982901.1; XM_001982865.1.
DR RefSeq; XP_001982906.1; XM_001982870.1.
DR RefSeq; XP_001982911.1; XM_001982875.1.
DR RefSeq; XP_001982915.1; XM_001982879.1.
DR RefSeq; XP_001982920.1; XM_001982884.1.
DR RefSeq; XP_001982925.1; XM_001982889.1.
DR RefSeq; XP_001982930.1; XM_001982894.1.
DR RefSeq; XP_001982934.1; XM_001982898.1.
DR RefSeq; XP_001982951.1; XM_001982915.1.
DR RefSeq; XP_001982956.1; XM_001982920.1.
DR RefSeq; XP_001983002.1; XM_001982966.1.
DR RefSeq; XP_001983007.1; XM_001982971.1.
DR RefSeq; XP_001983020.1; XM_001982984.1.
DR RefSeq; XP_001983046.1; XM_001983010.1.
DR RefSeq; XP_001983055.1; XM_001983019.2.
DR RefSeq; XP_001983059.1; XM_001983023.1.
DR RefSeq; XP_001983069.1; XM_001983033.1.
DR RefSeq; XP_001983104.1; XM_001983068.1.
DR RefSeq; XP_001983113.1; XM_001983077.2.
DR RefSeq; XP_001983142.1; XM_001983106.1.
DR AlphaFoldDB; P59781; -.
DR SMR; P59781; -.
DR EnsemblMetazoa; FBtr0131007; FBpp0129499; FBgn0103256.
DR EnsemblMetazoa; FBtr0131068; FBpp0129560; FBgn0103316.
DR EnsemblMetazoa; FBtr0131070; FBpp0129562; FBgn0103318.
DR EnsemblMetazoa; FBtr0131072; FBpp0129564; FBgn0103320.
DR EnsemblMetazoa; FBtr0131074; FBpp0129566; FBgn0103322.
DR EnsemblMetazoa; FBtr0131076; FBpp0129568; FBgn0103324.
DR EnsemblMetazoa; FBtr0132635; FBpp0131127; FBgn0104869.
DR EnsemblMetazoa; FBtr0132637; FBpp0131129; FBgn0104871.
DR EnsemblMetazoa; FBtr0132639; FBpp0131131; FBgn0104873.
DR EnsemblMetazoa; FBtr0133011; FBpp0131503; FBgn0105230.
DR EnsemblMetazoa; FBtr0133082; FBpp0131574; FBgn0105301.
DR EnsemblMetazoa; FBtr0133084; FBpp0131576; FBgn0105303.
DR EnsemblMetazoa; FBtr0133086; FBpp0131578; FBgn0105305.
DR EnsemblMetazoa; FBtr0133089; FBpp0131581; FBgn0105308.
DR EnsemblMetazoa; FBtr0133090; FBpp0131582; FBgn0105309.
DR EnsemblMetazoa; FBtr0133111; FBpp0131603; FBgn0105330.
DR EnsemblMetazoa; FBtr0133115; FBpp0131607; FBgn0105334.
DR EnsemblMetazoa; FBtr0136427; FBpp0134919; FBgn0108605.
DR EnsemblMetazoa; FBtr0138738; FBpp0137230; FBgn0110894.
DR EnsemblMetazoa; FBtr0139885; FBpp0138377; FBgn0112032.
DR EnsemblMetazoa; FBtr0139899; FBpp0138391; FBgn0112046.
DR EnsemblMetazoa; FBtr0139902; FBpp0138394; FBgn0112049.
DR EnsemblMetazoa; FBtr0141542; FBpp0140034; FBgn0113667.
DR EnsemblMetazoa; FBtr0141546; FBpp0140038; FBgn0113671.
DR EnsemblMetazoa; FBtr0141548; FBpp0140040; FBgn0113673.
DR GeneID; 6548707; -.
DR GeneID; 6548712; -.
DR GeneID; 6556031; -.
DR GeneID; 6556046; -.
DR GeneID; 6556051; -.
DR GeneID; 6556058; -.
DR GeneID; 6556228; -.
DR GeneID; 6556303; -.
DR GeneID; 6556359; -.
DR KEGG; der:6548707; -.
DR KEGG; der:6548712; -.
DR KEGG; der:6556031; -.
DR KEGG; der:6556046; -.
DR KEGG; der:6556051; -.
DR KEGG; der:6556058; -.
DR KEGG; der:6556228; -.
DR KEGG; der:6556303; -.
DR KEGG; der:6556359; -.
DR FlyBase; FBgn0064618; Dere\His2B.
DR eggNOG; KOG1744; Eukaryota.
DR HOGENOM; CLU_075666_2_0_1; -.
DR OMA; ELAKHAX; -.
DR OrthoDB; 1536672at2759; -.
DR PhylomeDB; P59781; -.
DR Proteomes; UP000008711; Unassembled WGS sequence.
DR GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0044877; F:protein-containing complex binding; ISS:UniProtKB.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR007125; Histone_H2A/H2B/H3.
DR InterPro; IPR000558; Histone_H2B.
DR PANTHER; PTHR23428; PTHR23428; 1.
DR Pfam; PF00125; Histone; 1.
DR PRINTS; PR00621; HISTONEH2B.
DR SMART; SM00427; H2B; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
DR PROSITE; PS00357; HISTONE_H2B; 1.
PE 3: Inferred from homology;
KW Chromosome; DNA-binding; Glycoprotein; Isopeptide bond; Methylation;
KW Nucleosome core; Nucleus; Ubl conjugation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..123
FT /note="Histone H2B"
FT /id="PRO_0000071858"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-methylproline"
FT /evidence="ECO:0000250"
FT CARBOHYD 110
FT /note="O-linked (GlcNAc) serine"
FT /evidence="ECO:0000250"
FT CROSSLNK 118
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT /evidence="ECO:0000250"
SQ SEQUENCE 123 AA; 13696 MW; 0774D25F34003062 CRC64;
MPPKTSGKAA KKAGKAQKNI TKTDKKKKRK RKESYAIYIY KVLKQVHPDT GISSKAMSIM
NSFVNDIFER IAAEASRLAH YNKRSTITSR EIQTAVRLLL PGELAKHAVS EGTKAVTKYT
SSK
