H2B_DROSE
ID H2B_DROSE Reviewed; 123 AA.
AC Q76FD7; B4ILY8;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Histone H2B;
GN Name=His2B;
GN and
GN ORFNames=GM10080;
GN and
GN ORFNames=GM11748;
GN and
GN ORFNames=GM11937;
GN and
GN ORFNames=GM13135;
GN and
GN ORFNames=GM13187;
GN and
GN ORFNames=GM13191;
GN and
GN ORFNames=GM13213;
GN and
GN ORFNames=GM13539;
GN and
GN ORFNames=GM13541;
GN and
GN ORFNames=GM13542;
GN and
GN ORFNames=GM13608;
GN and
GN ORFNames=GM13614;
GN and
GN ORFNames=GM13660;
GN and
GN ORFNames=GM15473;
GN and
GN ORFNames=GM16168;
GN and
GN ORFNames=GM16542;
GN and
GN ORFNames=GM17425;
GN and
GN ORFNames=GM17711;
GN and
GN ORFNames=GM18819;
GN and
GN ORFNames=GM19277;
GN and
GN ORFNames=GM19328;
GN and
GN ORFNames=GM19430;
GN and
GN ORFNames=GM19608;
GN and
GN ORFNames=GM19672;
GN and
GN ORFNames=GM19696;
GN and
GN ORFNames=GM19697;
GN and
GN ORFNames=GM19701;
GN and
GN ORFNames=GM19703;
GN and
GN ORFNames=GM19734;
GN and
GN ORFNames=GM19736;
GN and
GN ORFNames=GM19761;
GN and
GN ORFNames=GM22424;
GN and
GN ORFNames=GM22584;
GN and
GN ORFNames=GM23249;
GN and
GN ORFNames=GM23434;
GN and
GN ORFNames=GM23805;
GN and
GN ORFNames=GM24037;
GN and
GN ORFNames=GM26707;
GN and
GN ORFNames=GM26724;
OS Drosophila sechellia (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7238;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (HIS2B).
RX PubMed=14676429; DOI=10.1266/ggs.78.383;
RA Kakita M., Shimizu T., Emoto M., Nagai M., Takeguchi M., Hosono Y.,
RA Kume N., Ozawa T., Ueda M., Bhuiyan M.S., Matsuo Y.;
RT "Divergence and heterogeneity of the histone gene repeating units in the
RT Drosophila melanogaster species subgroup.";
RL Genes Genet. Syst. 78:383-389(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (GM10080; GM11748; GM11937;
RP GM13135; GM13187; GM13191; GM13213; GM13539; GM13541; GM13542; GM13608;
RP GM13614; GM13660; GM15473; GM16168; GM16542; GM17425; GM17711; GM18819;
RP GM19277; GM19328; GM19430; GM19608; GM19672; GM19696; GM19697; GM19701;
RP GM19703; GM19734; GM19736; GM19761; GM22424; GM22584; GM23249; GM23434;
RP GM23805; GM24037; GM26707 AND GM26724).
RC STRAIN=Rob3c / Tucson 14021-0248.25;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC DNA into chromatin, limiting DNA accessibility to the cellular
CC machineries which require DNA as a template. Histones thereby play a
CC central role in transcription regulation, DNA repair, DNA replication
CC and chromosomal stability. DNA accessibility is regulated via a complex
CC set of post-translational modifications of histones, also called
CC histone code, and nucleosome remodeling.
CC -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC DNA.
CC -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC -!- PTM: Monoubiquitination of Lys-118 by Bre1 gives a specific tag for
CC epigenetic transcriptional activation and is also prerequisite for
CC histone H3 'Lys-4' and 'Lys-79' methylation. {ECO:0000250}.
CC -!- PTM: GlcNAcylation at Ser-110 promotes monoubiquitination of Lys-118.
CC It fluctuates in response to extracellular glucose, and associates with
CC transcribed genes (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the histone H2B family. {ECO:0000305}.
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DR EMBL; AB105184; BAD02442.1; -; Genomic_DNA.
DR EMBL; CH480906; EDW56421.1; -; Genomic_DNA.
DR EMBL; CH480906; EDW56426.1; -; Genomic_DNA.
DR EMBL; CH480906; EDW56436.1; -; Genomic_DNA.
DR EMBL; CH480906; EDW56440.1; -; Genomic_DNA.
DR EMBL; CH481037; EDW49038.1; -; Genomic_DNA.
DR EMBL; CH481037; EDW49043.1; -; Genomic_DNA.
DR EMBL; CH481172; EDW51578.1; -; Genomic_DNA.
DR EMBL; CH481183; EDW52629.1; -; Genomic_DNA.
DR EMBL; CH481183; EDW52630.1; -; Genomic_DNA.
DR EMBL; CH481183; EDW52634.1; -; Genomic_DNA.
DR EMBL; CH481193; EDW52668.1; -; Genomic_DNA.
DR EMBL; CH481193; EDW52673.1; -; Genomic_DNA.
DR EMBL; CH481254; EDW52842.1; -; Genomic_DNA.
DR EMBL; CH481254; EDW52846.1; -; Genomic_DNA.
DR EMBL; CH481370; EDW54702.1; -; Genomic_DNA.
DR EMBL; CH481534; EDW55918.1; -; Genomic_DNA.
DR EMBL; CH482051; EDW48890.1; -; Genomic_DNA.
DR EMBL; CH482148; EDW49318.1; -; Genomic_DNA.
DR EMBL; CH676531; EDW53864.1; -; Genomic_DNA.
DR EMBL; CH676546; EDW54686.1; -; Genomic_DNA.
DR EMBL; CH676587; EDW55442.1; -; Genomic_DNA.
DR EMBL; CH677916; EDW49750.1; -; Genomic_DNA.
DR EMBL; CH678886; EDW51648.1; -; Genomic_DNA.
DR EMBL; CH679757; EDW52837.1; -; Genomic_DNA.
DR EMBL; CH680033; EDW53687.1; -; Genomic_DNA.
DR EMBL; CH680609; EDW53838.1; -; Genomic_DNA.
DR EMBL; CH680693; EDW53845.1; -; Genomic_DNA.
DR EMBL; CH682800; EDW55448.1; -; Genomic_DNA.
DR EMBL; CH682823; EDW55453.1; -; Genomic_DNA.
DR EMBL; CH683660; EDW55913.1; -; Genomic_DNA.
DR EMBL; CH684007; EDW56409.1; -; Genomic_DNA.
DR EMBL; CH684185; EDW56448.1; -; Genomic_DNA.
DR EMBL; CH684262; EDW56458.1; -; Genomic_DNA.
DR EMBL; CH684467; EDW56483.1; -; Genomic_DNA.
DR EMBL; CH684537; EDW56489.1; -; Genomic_DNA.
DR EMBL; CH685029; EDW43593.1; -; Genomic_DNA.
DR EMBL; CH685136; EDW43597.1; -; Genomic_DNA.
DR EMBL; CH685650; EDW43648.1; -; Genomic_DNA.
DR EMBL; CH686458; EDW44119.1; -; Genomic_DNA.
DR RefSeq; XP_002044748.1; XM_002044712.1.
DR RefSeq; XP_002044753.1; XM_002044717.1.
DR RefSeq; XP_002044763.1; XM_002044727.1.
DR RefSeq; XP_002044767.1; XM_002044731.1.
DR RefSeq; XP_002044957.1; XM_002044921.1.
DR RefSeq; XP_002044962.1; XM_002044926.1.
DR RefSeq; XP_002045038.1; XM_002045002.1.
DR RefSeq; XP_002045043.1; XM_002045007.1.
DR RefSeq; XP_002045044.1; XM_002045008.1.
DR RefSeq; XP_002045048.1; XM_002045012.1.
DR RefSeq; XP_002045052.1; XM_002045016.1.
DR RefSeq; XP_002045057.1; XM_002045021.1.
DR RefSeq; XP_002045094.1; XM_002045058.1.
DR RefSeq; XP_002045098.1; XM_002045062.1.
DR RefSeq; XP_002045125.1; XM_002045089.1.
DR RefSeq; XP_002045158.1; XM_002045122.1.
DR RefSeq; XP_002045248.1; XM_002045212.1.
DR RefSeq; XP_002045260.1; XM_002045224.1.
DR RefSeq; XP_002045365.1; XM_002045329.1.
DR RefSeq; XP_002045371.1; XM_002045335.1.
DR RefSeq; XP_002045381.1; XM_002045345.1.
DR RefSeq; XP_002045481.1; XM_002045445.1.
DR RefSeq; XP_002045551.1; XM_002045515.1.
DR RefSeq; XP_002045580.1; XM_002045544.1.
DR RefSeq; XP_002045588.1; XM_002045552.1.
DR RefSeq; XP_002045618.1; XM_002045582.1.
DR RefSeq; XP_002045623.1; XM_002045587.1.
DR RefSeq; XP_002045704.1; XM_002045668.1.
DR RefSeq; XP_002045708.1; XM_002045672.1.
DR RefSeq; XP_002045758.1; XM_002045722.1.
DR RefSeq; XP_002045777.1; XM_002045741.1.
DR RefSeq; XP_002045784.1; XM_002045748.1.
DR RefSeq; XP_002045792.1; XM_002045756.1.
DR RefSeq; XP_002045808.1; XM_002045772.1.
DR RefSeq; XP_002045814.1; XM_002045778.1.
DR RefSeq; XP_002045839.1; XM_002045803.1.
DR RefSeq; XP_002045841.1; XM_002045805.1.
DR RefSeq; XP_002045872.1; XM_002045836.1.
DR RefSeq; XP_002045908.1; XM_002045872.1.
DR AlphaFoldDB; Q76FD7; -.
DR SMR; Q76FD7; -.
DR EnsemblMetazoa; FBtr0193065; FBpp0191557; FBgn0165031.
DR EnsemblMetazoa; FBtr0194733; FBpp0193225; FBgn0166691.
DR EnsemblMetazoa; FBtr0194922; FBpp0193414; FBgn0166878.
DR EnsemblMetazoa; FBtr0196120; FBpp0194612; FBgn0168066.
DR EnsemblMetazoa; FBtr0196172; FBpp0194664; FBgn0168118.
DR EnsemblMetazoa; FBtr0196176; FBpp0194668; FBgn0168122.
DR EnsemblMetazoa; FBtr0196198; FBpp0194690; FBgn0168144.
DR EnsemblMetazoa; FBtr0196524; FBpp0195016; FBgn0168470.
DR EnsemblMetazoa; FBtr0196526; FBpp0195018; FBgn0168472.
DR EnsemblMetazoa; FBtr0196527; FBpp0195019; FBgn0168473.
DR EnsemblMetazoa; FBtr0196593; FBpp0195085; FBgn0168539.
DR EnsemblMetazoa; FBtr0196599; FBpp0195091; FBgn0168545.
DR EnsemblMetazoa; FBtr0196645; FBpp0195137; FBgn0168591.
DR EnsemblMetazoa; FBtr0198458; FBpp0196950; FBgn0170391.
DR EnsemblMetazoa; FBtr0199153; FBpp0197645; FBgn0171084.
DR EnsemblMetazoa; FBtr0199527; FBpp0198019; FBgn0171457.
DR EnsemblMetazoa; FBtr0200410; FBpp0198902; FBgn0172335.
DR EnsemblMetazoa; FBtr0200696; FBpp0199188; FBgn0172619.
DR EnsemblMetazoa; FBtr0201804; FBpp0200296; FBgn0173724.
DR EnsemblMetazoa; FBtr0202262; FBpp0200754; FBgn0174177.
DR EnsemblMetazoa; FBtr0202313; FBpp0200805; FBgn0174228.
DR EnsemblMetazoa; FBtr0202415; FBpp0200907; FBgn0174330.
DR EnsemblMetazoa; FBtr0202593; FBpp0201085; FBgn0174508.
DR EnsemblMetazoa; FBtr0202657; FBpp0201149; FBgn0174572.
DR EnsemblMetazoa; FBtr0202681; FBpp0201173; FBgn0174596.
DR EnsemblMetazoa; FBtr0202682; FBpp0201174; FBgn0174597.
DR EnsemblMetazoa; FBtr0202686; FBpp0201178; FBgn0174601.
DR EnsemblMetazoa; FBtr0202688; FBpp0201180; FBgn0174603.
DR EnsemblMetazoa; FBtr0202719; FBpp0201211; FBgn0174634.
DR EnsemblMetazoa; FBtr0202721; FBpp0201213; FBgn0174636.
DR EnsemblMetazoa; FBtr0202746; FBpp0201238; FBgn0174660.
DR EnsemblMetazoa; FBtr0205409; FBpp0203901; FBgn0177294.
DR EnsemblMetazoa; FBtr0205569; FBpp0204061; FBgn0177454.
DR EnsemblMetazoa; FBtr0206234; FBpp0204726; FBgn0178116.
DR EnsemblMetazoa; FBtr0206419; FBpp0204911; FBgn0178301.
DR EnsemblMetazoa; FBtr0206790; FBpp0205282; FBgn0178670.
DR EnsemblMetazoa; FBtr0207022; FBpp0205514; FBgn0178902.
DR EnsemblMetazoa; FBtr0209692; FBpp0208184; FBgn0181560.
DR EnsemblMetazoa; FBtr0209709; FBpp0208201; FBgn0181577.
DR FlyBase; FBgn0068723; Dsec\His2B.
DR HOGENOM; CLU_075666_2_0_1; -.
DR PhylomeDB; Q76FD7; -.
DR Proteomes; UP000001292; Unassembled WGS sequence.
DR GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0044877; F:protein-containing complex binding; ISS:UniProtKB.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR007125; Histone_H2A/H2B/H3.
DR InterPro; IPR000558; Histone_H2B.
DR PANTHER; PTHR23428; PTHR23428; 1.
DR Pfam; PF00125; Histone; 1.
DR PRINTS; PR00621; HISTONEH2B.
DR SMART; SM00427; H2B; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
DR PROSITE; PS00357; HISTONE_H2B; 1.
PE 3: Inferred from homology;
KW Chromosome; DNA-binding; Glycoprotein; Isopeptide bond; Methylation;
KW Nucleosome core; Nucleus; Reference proteome; Ubl conjugation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..123
FT /note="Histone H2B"
FT /id="PRO_0000071863"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-methylproline"
FT /evidence="ECO:0000250"
FT CARBOHYD 110
FT /note="O-linked (GlcNAc) serine"
FT /evidence="ECO:0000250"
FT CROSSLNK 118
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT /evidence="ECO:0000250"
SQ SEQUENCE 123 AA; 13709 MW; 64BBF38D20ABC4DD CRC64;
MPPKTSGKAA KKAGKAQKNI TKNDKKKKRK RKESYAIYIY KVLKQVHPDT GISSKAMSIM
NSFVNDIFER IAAEASRLAH YNKRSTITSR EIQTAVRLLL PGELAKHAVS EGTKAVTKYT
SSK
