ID   H2H01_CYRHA             Reviewed;          84 AA.
AC   D2Y219;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-MAR-2010, sequence version 1.
DT   25-MAY-2022, entry version 23.
DE   RecName: Full=U4-theraphotoxin-Hhn1ac;
DE            Short=U4-TRTX-Hhn1ac;
DE   AltName: Full=Hainantoxin-II-8;
DE            Short=HNTX-II-8;
DE   Flags: Precursor;
OS   Cyriopagopus hainanus (Chinese bird spider) (Haplopelma hainanum).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Haplopelma.
OX   NCBI_TaxID=209901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=20192277; DOI=10.1021/pr1000016;
RA   Tang X., Zhang Y., Hu W., Xu D., Tao H., Yang X., Li Y., Jiang L.,
RA   Liang S.;
RT   "Molecular diversification of peptide toxins from the tarantula Haplopelma
RT   hainanum (Ornithoctonus hainana) venom based on transcriptomic, peptidomic,
RT   and genomic analyses.";
RL   J. Proteome Res. 9:2550-2564(2010).
CC   -!- FUNCTION: Postsynaptic neurotoxin. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the neurotoxin 12 (Hwtx-2) family. 02 (Hwtx-2)
CC       subfamily. {ECO:0000305}.
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DR   EMBL; GU292896; ADB56712.1; -; mRNA.
DR   AlphaFoldDB; D2Y219; -.
DR   SMR; D2Y219; -.
DR   ArachnoServer; AS001763; U4-theraphotoxin-Hhn1ac.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0035792; C:host cell postsynaptic membrane; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR012625; Toxin_20.
DR   Pfam; PF08089; Toxin_20; 1.
DR   PROSITE; PS60022; HWTX_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Neurotoxin; Postsynaptic neurotoxin; Secreted; Signal;
KW   Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..47
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000400781"
FT   PEPTIDE         48..84
FT                   /note="U4-theraphotoxin-Hhn1ac"
FT                   /id="PRO_0000400782"
FT   DISULFID        51..65
FT                   /evidence="ECO:0000250"
FT   DISULFID        55..76
FT                   /evidence="ECO:0000250"
FT   DISULFID        70..81
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   84 AA;  9309 MW;  9C71BDFEC54662DF CRC64;
     MKVTLIAILT CAAVLVLHTT AAEELEESQL MEVGMPDTEL AAVDEERLFE CSVSCEIEKE
     GNKDCKKKKC KGGWKCKFNI CVKV