H2O01_CYRHA
ID H2O01_CYRHA Reviewed; 85 AA.
AC D2Y226;
DT 02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 02-MAR-2010, sequence version 1.
DT 25-MAY-2022, entry version 24.
DE RecName: Full=U4-theraphotoxin-Hhn1g;
DE Short=U4-TRTX-Hhn1g;
DE AltName: Full=Hainantoxin-II-15;
DE Short=HNTX-II-15;
DE Flags: Precursor;
OS Cyriopagopus hainanus (Chinese bird spider) (Haplopelma hainanum).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC Mygalomorphae; Theraphosidae; Haplopelma.
OX NCBI_TaxID=209901;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Venom gland;
RX PubMed=20192277; DOI=10.1021/pr1000016;
RA Tang X., Zhang Y., Hu W., Xu D., Tao H., Yang X., Li Y., Jiang L.,
RA Liang S.;
RT "Molecular diversification of peptide toxins from the tarantula Haplopelma
RT hainanum (Ornithoctonus hainana) venom based on transcriptomic, peptidomic,
RT and genomic analyses.";
RL J. Proteome Res. 9:2550-2564(2010).
CC -!- FUNCTION: Postsynaptic neurotoxin. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- SIMILARITY: Belongs to the neurotoxin 12 (Hwtx-2) family. 02 (Hwtx-2)
CC subfamily. {ECO:0000305}.
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DR EMBL; GU292903; ADB56719.1; -; mRNA.
DR AlphaFoldDB; D2Y226; -.
DR ArachnoServer; AS001557; U4-theraphotoxin-Hhn1g.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0035792; C:host cell postsynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR012625; Toxin_20.
DR Pfam; PF08089; Toxin_20; 1.
DR PROSITE; PS60022; HWTX_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Neurotoxin; Postsynaptic neurotoxin; Secreted; Signal;
KW Toxin.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT PROPEP 23..48
FT /evidence="ECO:0000250"
FT /id="PRO_0000400797"
FT PEPTIDE 49..85
FT /note="U4-theraphotoxin-Hhn1g"
FT /id="PRO_0000400798"
FT DISULFID 52..66
FT /evidence="ECO:0000250"
FT DISULFID 56..77
FT /evidence="ECO:0000250"
FT DISULFID 71..82
FT /evidence="ECO:0000250"
SQ SEQUENCE 85 AA; 9456 MW; 0D19D27A0D8EF53C CRC64;
MKVTLIAILT CAAVLVLHTT AAEELEAESQ LMEVGMPDTE LAAVDEERLF ECSVSCEIEK
EDNKDCKKKK CKGGWKCKFN MCVKV