ID   H2_VACCA                Reviewed;         189 AA.
AC   O57205; Q80HW4;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Late protein H2;
GN   OrderedLocusNames=MVA092R, ACAM3000_MVA_092;
OS   Vaccinia virus (strain Ankara) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=126794;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9601507; DOI=10.1006/viro.1998.9123;
RA   Antoine G., Scheiflinger F., Dorner F., Falkner F.G.;
RT   "The complete genomic sequence of the modified vaccinia Ankara strain:
RT   comparison with other orthopoxviruses.";
RL   Virology 244:365-396(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate Acambis 3000;
RA   Esposito J.J., Frace M., Sammons S.A., Olsen-Rasmussen M.S., Osborne J.,
RA   Khristova M., Wohlhueter R.M.;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Late protein Required for virus entry into host cell and for
CC       cell-cell fusion (syncytium formation). {ECO:0000250}.
CC   -!- SUBUNIT: Part of a stable entry-fusion complex (EFC) which is at least
CC       composed of proteins A16, A21, A28, G3, G9, H2, J5, and L5. Formation
CC       of the viral membrane is necessary for the assembly of the complex (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass type
CC       III membrane protein {ECO:0000305}. Note=Component of the intracellular
CC       mature virion (IMV) outer membrane. {ECO:0000250}.
CC   -!- PTM: Contains two intramolecular disulfide bonds. They are created by
CC       the viral disulfide bond formation pathway, a poxvirus-specific pathway
CC       that operates on the cytoplasmic side of the IMV membranes (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviruses H2 family. {ECO:0000305}.
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DR   EMBL; U94848; AAB96507.1; -; Genomic_DNA.
DR   EMBL; AY603355; AAT10490.1; -; Genomic_DNA.
DR   PIR; T37368; T37368.
DR   RefSeq; YP_232982.1; NC_006998.1.
DR   SMR; O57205; -.
DR   DNASU; 3707556; -.
DR   GeneID; 3707556; -.
DR   KEGG; vg:3707556; -.
DR   Proteomes; UP000159908; Genome.
DR   Proteomes; UP000172909; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0039663; P:membrane fusion involved in viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   InterPro; IPR005023; Pox_LP_H2.
DR   Pfam; PF03356; Pox_LP_H2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Fusion of virus membrane with host membrane; Late protein;
KW   Membrane; Signal-anchor; Transmembrane; Transmembrane helix;
KW   Viral penetration into host cytoplasm; Virion; Virus entry into host cell.
FT   CHAIN           1..189
FT                   /note="Late protein H2"
FT                   /id="PRO_0000099546"
FT   TOPO_DOM        1..28
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        29..49
FT                   /note="Helical; Signal-anchor for type III membrane
FT                   protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        50..189
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   189 AA;  21543 MW;  FFE12787A38C4794 CRC64;
     MDKTTLSVNA CNLEYVREKA IVGVQAAKTS TLIFFVIILA ISALLLWFQT SDNPVFNELT
     RYMRIKNTVN DWKSLTDSKT KLESDRGRLL AAGKDDIFEF KCVDFGAYFI AMRLDKKTYL
     PQAIRRGTGD AWMVKKAAKV DPSAQQFCQY LIKHKSNNVI TCGNEMLNEL GYSGYFMSPH
     WCSDFSNME