H2_VAR67
ID H2_VAR67 Reviewed; 189 AA.
AC P0DSY9; P33061;
DT 16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT 16-OCT-2019, sequence version 1.
DT 25-MAY-2022, entry version 7.
DE RecName: Full=Late protein H2;
GN ORFNames=H2R, I2R;
OS Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX NCBI_TaxID=587200;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8383392; DOI=10.1016/0168-1702(93)90110-9;
RA Shchelkunov S.N., Blinov V.M., Totmenin A.V., Marennikova S.S.,
RA Kolykhalov A.A., Frolov I.V., Chizhikov V.E., Gytorov V.V., Gashikov P.V.,
RA Belanov E.F., Belavin P.A., Resenchuk S.M., Andzhaparidze O.G.,
RA Sandakhchiev L.S.;
RT "Nucleotide sequence analysis of variola virus HindIII M, L, I genome
RT fragments.";
RL Virus Res. 27:25-35(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8384129; DOI=10.1016/0014-5793(93)80041-r;
RA Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT "Genes of variola and vaccinia viruses necessary to overcome the host
RT protective mechanisms.";
RL FEBS Lett. 319:80-83(1993).
CC -!- FUNCTION: Envelope protein part of the entry-fusion complex responsible
CC for the virus membrane fusion with host cell membrane during virus
CC entry. Also plays a role in cell-cell fusion (syncytium formation) (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Part of a stable entry-fusion complex (EFC) which is at least
CC composed of proteins A16, A21, A28, G3, G9, H2, J5, and L5. Formation
CC of the viral membrane is necessary for the assembly of the complex (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass type
CC III membrane protein {ECO:0000305}. Note=Component of the mature virion
CC (MV) membrane. The mature virion is located in the cytoplasm of
CC infected cells and is probably released by cell lysis. {ECO:0000250}.
CC -!- PTM: Contains two intramolecular disulfide bonds. They are created by
CC the viral disulfide bond formation pathway, a poxvirus-specific pathway
CC that operates on the cytoplasmic side of the MV membranes (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the poxviridae H2 family. {ECO:0000305}.
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DR EMBL; X67119; CAA47584.1; -; Genomic_DNA.
DR EMBL; S55844; AAB24681.1; -; Genomic_DNA.
DR EMBL; X69198; CAA49026.1; -; Genomic_DNA.
DR PIR; A36846; A36846.
DR RefSeq; NP_042129.1; NC_001611.1.
DR SMR; P0DSY9; -.
DR GeneID; 1486440; -.
DR KEGG; vg:1486440; -.
DR Proteomes; UP000002060; Genome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019064; P:fusion of virus membrane with host plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR InterPro; IPR005023; Pox_LP_H2.
DR Pfam; PF03356; Pox_LP_H2; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Fusion of virus membrane with host cell membrane;
KW Fusion of virus membrane with host membrane; Late protein; Membrane;
KW Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix;
KW Viral envelope protein; Viral penetration into host cytoplasm; Virion;
KW Virus entry into host cell.
FT CHAIN 1..189
FT /note="Late protein H2"
FT /id="PRO_0000099549"
FT TOPO_DOM 1..28
FT /note="Intravirion"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical; Signal-anchor for type III membrane
FT protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..189
FT /note="Virion surface"
FT /evidence="ECO:0000255"
SQ SEQUENCE 189 AA; 21509 MW; FFE12787AD6C4794 CRC64;
MDKTTLSVNA CNLEYVREKA IVGVQAAKTS TLIFFVIILA ISALLLWFQT SDNPVFNELT
RYMRIKNTVN DWKSLTDSKT KLESDRGRLL AAGKDDIFEF KCVDFGAYFI AMRLDKKTYL
PQAIRRGTGD AWMVKKAAKV DPSAQQFCQY LIKHKSNNVI TCGNEMLNEL GYSGYFMSPH
WCSDLSNME