ID   H3_GUITH                Reviewed;         136 AA.
AC   Q98RY4;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Histone H3;
OS   Guillardia theta (Cryptophyte) (Cryptomonas phi).
OG   Nucleomorph.
OC   Eukaryota; Cryptophyceae; Pyrenomonadales; Geminigeraceae; Guillardia.
OX   NCBI_TaxID=55529;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11323671; DOI=10.1038/35074092;
RA   Douglas S.E., Zauner S., Fraunholz M., Beaton M., Penny S.L., Deng L.-T.,
RA   Wu X., Reith M.E., Cavalier-Smith T., Maier U.-G.;
RT   "The highly reduced genome of an enslaved algal nucleus.";
RL   Nature 410:1091-1096(2001).
CC   -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC       DNA into chromatin, limiting DNA accessibility to the cellular
CC       machineries which require DNA as a template. Histones thereby play a
CC       central role in transcription regulation, DNA repair, DNA replication
CC       and chromosomal stability. DNA accessibility is regulated via a complex
CC       set of post-translational modifications of histones, also called
CC       histone code, and nucleosome remodeling.
CC   -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC       each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC       two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC       DNA.
CC   -!- SUBCELLULAR LOCATION: Nucleomorph {ECO:0000250}. Chromosome
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the histone H3 family. {ECO:0000305}.
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DR   EMBL; AF165818; AAK39816.1; -; Genomic_DNA.
DR   PIR; E90085; E90085.
DR   RefSeq; XP_001713521.1; XM_001713469.1.
DR   AlphaFoldDB; Q98RY4; -.
DR   SMR; Q98RY4; -.
DR   GeneID; 857304; -.
DR   GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   Gene3D; 1.10.20.10; -; 1.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR007125; Histone_H2A/H2B/H3.
DR   InterPro; IPR000164; Histone_H3/CENP-A.
DR   PANTHER; PTHR11426; PTHR11426; 1.
DR   Pfam; PF00125; Histone; 1.
DR   PRINTS; PR00622; HISTONEH3.
DR   SMART; SM00428; H3; 1.
DR   SUPFAM; SSF47113; SSF47113; 1.
PE   3: Inferred from homology;
KW   Chromosome; DNA-binding; Nucleomorph; Nucleosome core.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..136
FT                   /note="Histone H3"
FT                   /id="PRO_0000221278"
SQ   SEQUENCE   136 AA;  15810 MW;  F2CE3C3FD8087087 CRC64;
     MARTKQTARK TVGGDINSRI SEKRAKSDNS KNIDLKKVHR YKPGTVALRE IRKYQKSTNL
     LIRKLPFQRL VRELAQDYKS DLRFQNSAVL ALQEASESYL VNLFEDTNLC AIHAKRVTIM
     PKDIYLARRI RGEMIF