ID   H3_VACCP                Reviewed;          56 AA.
AC   P30895;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   29-SEP-2021, entry version 56.
DE   RecName: Full=Envelope protein H3;
DE   AltName: Full=Ag35;
DE   AltName: Full=Virion envelope protein p35;
DE   Flags: Fragments;
GN   ORFNames=H3L;
OS   Vaccinia virus (strain L-IVP) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=31531;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=1508163;
RA   Zinov'Ev V.V., Ovechnika L.G., Matskova L.V., Balakhnin S.M., Malygin E.G.,
RA   Chertov O.Y., Telezhinskaya I.N., Zaitseva E.V., Golubeva T.B.;
RT   "Identification of the gene for the immunodominant p35 protein from
RT   vaccinia virus.";
RL   Mol. Biol. (Mosk.) 26:142-149(1992).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=7926801; DOI=10.1016/0378-1119(94)90067-1;
RA   Zinoviev V.V., Tchikaev N.A., Chertov O.Y.U., Malygin E.G.;
RT   "Identification of the gene encoding vaccinia virus immunodominant protein
RT   p35.";
RL   Gene 147:209-214(1994).
CC   -!- FUNCTION: Envelope protein that binds to heparan sulfate on the cell
CC       surface and might provide virion attachment to target cell.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250}; Single-pass
CC       membrane protein {ECO:0000250}. Note=Component of the mature virion
CC       (MV) membrane. Becomes membrane associated presumably during virus
CC       maturation. The mature virion is located in the cytoplasm of infected
CC       cells and is probably released by cell lysis (By similarity).
CC       {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- PTM: Does not contain disulfide bonds. {ECO:0000250}.
CC   -!- MISCELLANEOUS: Immunodominant protein. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae protein H3 family.
CC       {ECO:0000305}.
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DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Host-virus interaction; Late protein; Membrane;
KW   Viral attachment to host cell; Viral envelope protein; Virion;
KW   Virus entry into host cell.
FT   CHAIN           <1..>56
FT                   /note="Envelope protein H3"
FT                   /id="PRO_0000099207"
FT   NON_CONS        20..21
FT                   /evidence="ECO:0000305"
FT   NON_CONS        41..42
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
FT   NON_TER         56
SQ   SEQUENCE   56 AA;  6603 MW;  3FA3F519F5412BD2 CRC64;
     PEKRNVVVVK DDPDHYKDYA HDKKIDXXXR FIITGNKVKT EKINRQILDN AAKYVE