H42_WHEAT
ID H42_WHEAT Reviewed; 103 AA.
AC P62786; P02308; P59258;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=Histone H4 variant TH091;
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=cv. Horoshirikomugi;
RX PubMed=6526273; DOI=10.1016/0378-1119(84)90223-3;
RA Tabata T., Iwabuchi M.;
RT "Molecular cloning and nucleotide sequence of a variant wheat histone H4
RT gene.";
RL Gene 31:285-289(1984).
CC -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC DNA into chromatin, limiting DNA accessibility to the cellular
CC machineries which require DNA as a template. Histones thereby play a
CC central role in transcription regulation, DNA repair, DNA replication
CC and chromosomal stability. DNA accessibility is regulated via a complex
CC set of post-translational modifications of histones, also called
CC histone code, and nucleosome remodeling.
CC -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC DNA.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the histone H4 family. {ECO:0000305}.
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DR EMBL; M12277; AAA34292.1; -; Genomic_DNA.
DR PIR; A24967; HSWT41.
DR AlphaFoldDB; P62786; -.
DR SMR; P62786; -.
DR PRIDE; P62786; -.
DR EnsemblPlants; TraesCAD_scaffold_015810_01G000100.1; TraesCAD_scaffold_015810_01G000100.1; TraesCAD_scaffold_015810_01G000100.
DR EnsemblPlants; TraesCLE_scaffold_023708_01G000100.1; TraesCLE_scaffold_023708_01G000100.1; TraesCLE_scaffold_023708_01G000100.
DR EnsemblPlants; TraesCS2D02G413100.1; TraesCS2D02G413100.1.cds1; TraesCS2D02G413100.
DR EnsemblPlants; TraesPAR_scaffold_067520_01G000100.1; TraesPAR_scaffold_067520_01G000100.1; TraesPAR_scaffold_067520_01G000100.
DR EnsemblPlants; TraesROB_scaffold_072401_01G000200.1; TraesROB_scaffold_072401_01G000200.1; TraesROB_scaffold_072401_01G000200.
DR EnsemblPlants; TraesWEE_scaffold_041774_01G000200.1; TraesWEE_scaffold_041774_01G000200.1; TraesWEE_scaffold_041774_01G000200.
DR Gramene; TraesCAD_scaffold_015810_01G000100.1; TraesCAD_scaffold_015810_01G000100.1; TraesCAD_scaffold_015810_01G000100.
DR Gramene; TraesCLE_scaffold_023708_01G000100.1; TraesCLE_scaffold_023708_01G000100.1; TraesCLE_scaffold_023708_01G000100.
DR Gramene; TraesCS2D02G413100.1; TraesCS2D02G413100.1.cds1; TraesCS2D02G413100.
DR Gramene; TraesPAR_scaffold_067520_01G000100.1; TraesPAR_scaffold_067520_01G000100.1; TraesPAR_scaffold_067520_01G000100.
DR Gramene; TraesROB_scaffold_072401_01G000200.1; TraesROB_scaffold_072401_01G000200.1; TraesROB_scaffold_072401_01G000200.
DR Gramene; TraesWEE_scaffold_041774_01G000200.1; TraesWEE_scaffold_041774_01G000200.1; TraesWEE_scaffold_041774_01G000200.
DR Proteomes; UP000019116; Unplaced.
DR GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR CDD; cd00076; H4; 1.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR035425; CENP-T/H4_C.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR001951; Histone_H4.
DR InterPro; IPR019809; Histone_H4_CS.
DR Pfam; PF15511; CENP-T_C; 1.
DR PRINTS; PR00623; HISTONEH4.
DR SMART; SM00417; H4; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
DR PROSITE; PS00047; HISTONE_H4; 1.
PE 3: Inferred from homology;
KW Acetylation; Chromosome; DNA-binding; Nucleosome core; Nucleus;
KW Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..103
FT /note="Histone H4 variant TH091"
FT /id="PRO_0000158374"
FT DNA_BIND 17..21
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250"
FT MOD_RES 6
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250"
FT MOD_RES 9
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250"
FT MOD_RES 13
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250"
FT MOD_RES 17
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250"
FT MOD_RES 21
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 103 AA; 11467 MW; 39C2558D88D75A4A CRC64;
MSGRDKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL IYEETRGVLK
IFLENVIRDA VTYTEHARRK TVTAMDVVYA LKRQGRTLYG FGG
