H4G_HUMAN
ID H4G_HUMAN Reviewed; 98 AA.
AC Q99525;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Histone H4-like protein type G;
DE AltName: Full=H4-clustered histone 7 {ECO:0000312|HGNC:HGNC:4792};
GN Name=H4C7 {ECO:0000312|HGNC:HGNC:4792};
GN Synonyms=H4/L, H4FL, HIST1H4G {ECO:0000312|HGNC:HGNC:4792};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9119399; DOI=10.1006/geno.1996.4592;
RA Albig W., Kioschis P., Poustka A., Meergans K., Doenecke D.;
RT "Human histone gene organization: nonregular arrangement within a large
RT cluster.";
RL Genomics 40:314-322(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12408966; DOI=10.1006/geno.2002.6850;
RA Marzluff W.F., Gongidi P., Woods K.R., Jin J., Maltais L.J.;
RT "The human and mouse replication-dependent histone genes.";
RL Genomics 80:487-498(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC DNA into chromatin, limiting DNA accessibility to the cellular
CC machineries which require DNA as a template. Histones thereby play a
CC central role in transcription regulation, DNA repair, DNA replication
CC and chromosomal stability. DNA accessibility is regulated via a complex
CC set of post-translational modifications of histones, also called
CC histone code, and nucleosome remodeling (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
CC (By similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC Q99525; Q6RW13: AGTRAP; NbExp=3; IntAct=EBI-10294329, EBI-741181;
CC Q99525; P02654: APOC1; NbExp=3; IntAct=EBI-10294329, EBI-1220105;
CC Q99525; Q9UHD4: CIDEB; NbExp=3; IntAct=EBI-10294329, EBI-7062247;
CC Q99525; Q92915-2: FGF14; NbExp=3; IntAct=EBI-10294329, EBI-12836320;
CC Q99525; Q9Y680: FKBP7; NbExp=3; IntAct=EBI-10294329, EBI-3918971;
CC Q99525; Q8WWC4: MAIP1; NbExp=3; IntAct=EBI-10294329, EBI-1042937;
CC Q99525; Q6NTF9-3: RHBDD2; NbExp=3; IntAct=EBI-10294329, EBI-17589229;
CC Q99525; Q6PL24: TMED8; NbExp=3; IntAct=EBI-10294329, EBI-11603430;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the histone H4 family. {ECO:0000305}.
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DR EMBL; Z80788; CAB02550.1; -; Genomic_DNA.
DR EMBL; AY128660; AAN01445.1; -; Genomic_DNA.
DR EMBL; AL031777; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471087; EAW55550.1; -; Genomic_DNA.
DR EMBL; BC126276; AAI26277.1; -; mRNA.
DR EMBL; BC126278; AAI26279.1; -; mRNA.
DR CCDS; CCDS4599.1; -.
DR RefSeq; NP_003538.1; NM_003547.2.
DR AlphaFoldDB; Q99525; -.
DR SMR; Q99525; -.
DR BioGRID; 113965; 22.
DR IntAct; Q99525; 10.
DR STRING; 9606.ENSP00000477870; -.
DR iPTMnet; Q99525; -.
DR PhosphoSitePlus; Q99525; -.
DR BioMuta; HIST1H4G; -.
DR DMDM; 74752149; -.
DR jPOST; Q99525; -.
DR MassIVE; Q99525; -.
DR PaxDb; Q99525; -.
DR PeptideAtlas; Q99525; -.
DR PRIDE; Q99525; -.
DR ProteomicsDB; 78310; -.
DR DNASU; 8369; -.
DR Ensembl; ENST00000611444.2; ENSP00000477870.2; ENSG00000275663.2.
DR GeneID; 8369; -.
DR KEGG; hsa:8369; -.
DR MANE-Select; ENST00000611444.2; ENSP00000477870.2; NM_003547.3; NP_003538.1.
DR UCSC; uc003nhf.4; human.
DR CTD; 8369; -.
DR DisGeNET; 8369; -.
DR GeneCards; H4C7; -.
DR HGNC; HGNC:4792; H4C7.
DR HPA; ENSG00000275663; Not detected.
DR MIM; 602832; gene.
DR neXtProt; NX_Q99525; -.
DR OpenTargets; ENSG00000275663; -.
DR VEuPathDB; HostDB:ENSG00000275663; -.
DR eggNOG; KOG3467; Eukaryota.
DR GeneTree; ENSGT01050000244867; -.
DR HOGENOM; CLU_109117_2_3_1; -.
DR InParanoid; Q99525; -.
DR OMA; LENVIWY; -.
DR OrthoDB; 1594208at2759; -.
DR PhylomeDB; Q99525; -.
DR PathwayCommons; Q99525; -.
DR SignaLink; Q99525; -.
DR BioGRID-ORCS; 8369; 16 hits in 1065 CRISPR screens.
DR GeneWiki; HIST1H4G; -.
DR GenomeRNAi; 8369; -.
DR Pharos; Q99525; Tdark.
DR PRO; PR:Q99525; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q99525; protein.
DR Bgee; ENSG00000275663; Expressed in tibialis anterior and 12 other tissues.
DR Genevisible; Q99525; HS.
DR GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; HDA:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0006334; P:nucleosome assembly; IBA:GO_Central.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR001951; Histone_H4.
DR PRINTS; PR00623; HISTONEH4.
DR SMART; SM00417; H4; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
PE 1: Evidence at protein level;
KW Chromosome; DNA-binding; Nucleosome core; Nucleus; Reference proteome.
FT CHAIN 1..98
FT /note="Histone H4-like protein type G"
FT /id="PRO_0000324392"
FT DNA_BIND 17..21
FT /evidence="ECO:0000250"
SQ SEQUENCE 98 AA; 11009 MW; B76078AC96AE4DEB CRC64;
MSVRGKAGKG LGKGGAKCHR KVLSDNIQGI TKCTIRRLAR HGGVKRILGL IYEETRRVFK
VFLENVIWYA VTNTEHAKRK TVTAMAVVYV LKRQGRTL
