ID   H4Y_BLEJA               Reviewed;          48 AA.
AC   P80738;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Histone H4;
DE   Flags: Fragment;
OS   Blepharisma japonicum.
OC   Eukaryota; Sar; Alveolata; Ciliophora; Postciliodesmatophora;
OC   Heterotrichea; Heterotrichida; Blepharismidae; Blepharisma.
OX   NCBI_TaxID=5961;
RN   [1]
RP   PROTEIN SEQUENCE OF 2-48.
RC   STRAIN=A5-3;
RX   PubMed=9103980; DOI=10.1111/j.1574-6968.1997.tb10314.x;
RA   Salvini M., Bini E., Santucci A., Batistoni R.;
RT   "H4 histone in the macronucleus of Blepharisma japonicum (Protozoa,
RT   Ciliophora, Heterotrichida).";
RL   FEMS Microbiol. Lett. 149:93-98(1997).
CC   -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC       DNA into chromatin, limiting DNA accessibility to the cellular
CC       machineries which require DNA as a template. Histones thereby play a
CC       central role in transcription regulation, DNA repair, DNA replication
CC       and chromosomal stability. DNA accessibility is regulated via a complex
CC       set of post-translational modifications of histones, also called
CC       histone code, and nucleosome remodeling.
CC   -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC       each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC       two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC       DNA.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the histone H4 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P80738; -.
DR   SMR; P80738; -.
DR   GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   Gene3D; 1.10.20.10; -; 1.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR001951; Histone_H4.
DR   PRINTS; PR00623; HISTONEH4.
DR   SUPFAM; SSF47113; SSF47113; 1.
PE   1: Evidence at protein level;
KW   Chromosome; Direct protein sequencing; DNA-binding; Nucleosome core;
KW   Nucleus.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:9103980"
FT   CHAIN           2..>48
FT                   /note="Histone H4"
FT                   /id="PRO_0000158288"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         48
SQ   SEQUENCE   48 AA;  5092 MW;  6AF51C973B76BA80 CRC64;
     MGGKGGKGGK GLGKVGAKKR HSRRVIRENI QGITKPAIRR LARRGGVK