H4_CANGA
ID H4_CANGA Reviewed; 103 AA.
AC Q8NIG3;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Histone H4;
GN Name=HHF1; OrderedLocusNames=CAGL0C04136g;
GN and
GN Name=HHF2; OrderedLocusNames=CAGL0H09834g;
GN and
GN Name=HHF3; OrderedLocusNames=CAGL0M06677g;
OS Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS Y-65) (Yeast) (Torulopsis glabrata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC Nakaseomyces/Candida clade.
OX NCBI_TaxID=284593;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX PubMed=12093907; DOI=10.1073/pnas.142101099;
RA Wong S., Butler G., Wolfe K.H.;
RT "Gene order evolution and paleopolyploidy in hemiascomycete yeasts.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:9272-9277(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC DNA into chromatin, limiting DNA accessibility to the cellular
CC machineries which require DNA as a template. Histones thereby play a
CC central role in transcription regulation, DNA repair, DNA replication
CC and chromosomal stability. DNA accessibility is regulated via a complex
CC set of post-translational modifications of histones, also called
CC histone code, and nucleosome remodeling (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC -!- PTM: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by
CC promoting dissociation of the H2A-H2B dimers from nucleosomes.
CC {ECO:0000250|UniProtKB:P02309}.
CC -!- SIMILARITY: Belongs to the histone H4 family. {ECO:0000305}.
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DR EMBL; AF520060; AAM74210.1; -; Genomic_DNA.
DR EMBL; AF520061; AAM74216.1; -; Genomic_DNA.
DR EMBL; CR380949; CAG58261.1; -; Genomic_DNA.
DR EMBL; CR380954; CAG60158.1; -; Genomic_DNA.
DR EMBL; CR380959; CAG62614.1; -; Genomic_DNA.
DR RefSeq; XP_445355.1; XM_445355.1.
DR RefSeq; XP_447225.1; XM_447225.1.
DR RefSeq; XP_449638.1; XM_449638.1.
DR AlphaFoldDB; Q8NIG3; -.
DR SMR; Q8NIG3; -.
DR STRING; 5478.XP_445355.1; -.
DR EnsemblFungi; CAG58261; CAG58261; CAGL0C04136g.
DR EnsemblFungi; CAG60158; CAG60158; CAGL0H09834g.
DR EnsemblFungi; CAG62614; CAG62614; CAGL0M06677g.
DR GeneID; 2886845; -.
DR GeneID; 2888694; -.
DR GeneID; 2891686; -.
DR KEGG; cgr:CAGL0C04136g; -.
DR KEGG; cgr:CAGL0H09834g; -.
DR KEGG; cgr:CAGL0M06677g; -.
DR CGD; CAL0127348; HHF1.
DR CGD; CAL0136709; HHF2.
DR CGD; CAL0131500; HHF3.
DR VEuPathDB; FungiDB:CAGL0C04136g; -.
DR VEuPathDB; FungiDB:CAGL0H09834g; -.
DR VEuPathDB; FungiDB:CAGL0M06677g; -.
DR eggNOG; KOG3467; Eukaryota.
DR HOGENOM; CLU_109117_2_3_1; -.
DR InParanoid; Q8NIG3; -.
DR OMA; QKEHING; -.
DR Proteomes; UP000002428; Chromosome C.
DR Proteomes; UP000002428; Chromosome H.
DR Proteomes; UP000002428; Chromosome M.
DR GO; GO:0062040; C:fungal biofilm matrix; IDA:CGD.
DR GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR CDD; cd00076; H4; 1.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR035425; CENP-T/H4_C.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR001951; Histone_H4.
DR InterPro; IPR019809; Histone_H4_CS.
DR Pfam; PF15511; CENP-T_C; 1.
DR PRINTS; PR00623; HISTONEH4.
DR SMART; SM00417; H4; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
DR PROSITE; PS00047; HISTONE_H4; 1.
PE 3: Inferred from homology;
KW Chromosome; DNA-binding; Nucleosome core; Nucleus; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..103
FT /note="Histone H4"
FT /id="PRO_0000158292"
FT DNA_BIND 17..21
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 92
FT /note="N6-glutaryllysine"
FT /evidence="ECO:0000250|UniProtKB:P02309"
SQ SEQUENCE 103 AA; 11352 MW; 69AE3666FE62DE41 CRC64;
MSGRGKGGKG LGKGGAKRHR KILRDNIQGI TKPAIRRLAR RGGVKRISGL IYEEVRAVLK
SFLESVIRDA VTYTEHAKRK TVTSLDVVYA LKRQGRTLYG FGG
