H4_CHLRE
ID H4_CHLRE Reviewed; 103 AA.
AC P50566;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Histone H4;
GN Name=H4-I;
GN and
GN Name=H4-II;
GN and
GN Name=H4-III;
OS Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX NCBI_TaxID=3055;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=137c / CC-125;
RX PubMed=7479007; DOI=10.1093/nar/23.18.3756;
RA Walther Z., Hall J.L.;
RT "The uni chromosome of Chlamydomonas: histone genes and nucleosome
RT structure.";
RL Nucleic Acids Res. 23:3756-3763(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8590479; DOI=10.1007/bf00326431;
RA Fabry S., Mueller K., Lindauer A., Park P.B., Cornelius T., Schmitt R.;
RT "The organization structure and regulatory elements of Chlamydomonas
RT histone genes reveal features linking plant and animal genes.";
RL Curr. Genet. 28:333-345(1995).
CC -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC DNA into chromatin, limiting DNA accessibility to the cellular
CC machineries which require DNA as a template. Histones thereby play a
CC central role in transcription regulation, DNA repair, DNA replication
CC and chromosomal stability. DNA accessibility is regulated via a complex
CC set of post-translational modifications of histones, also called
CC histone code, and nucleosome remodeling.
CC -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC DNA.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the histone H4 family. {ECO:0000305}.
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DR EMBL; L41841; AAA99966.1; -; Genomic_DNA.
DR EMBL; U16724; AAA98445.1; -; Genomic_DNA.
DR EMBL; U16725; AAA98449.1; -; Genomic_DNA.
DR EMBL; U16825; AAA98456.1; -; Genomic_DNA.
DR PIR; S59586; S59586.
DR RefSeq; XP_001690685.1; XM_001690633.1.
DR RefSeq; XP_001690721.1; XM_001690669.1.
DR RefSeq; XP_001690810.1; XM_001690758.1.
DR RefSeq; XP_001690828.1; XM_001690776.1.
DR RefSeq; XP_001690996.1; XM_001690944.1.
DR RefSeq; XP_001691002.1; XM_001690950.1.
DR RefSeq; XP_001691010.1; XM_001690958.1.
DR RefSeq; XP_001691527.1; XM_001691475.1.
DR RefSeq; XP_001691544.1; XM_001691492.1.
DR RefSeq; XP_001691698.1; XM_001691646.1.
DR RefSeq; XP_001692372.1; XM_001692320.1.
DR RefSeq; XP_001696174.1; XM_001696122.1.
DR RefSeq; XP_001696191.1; XM_001696139.1.
DR RefSeq; XP_001696262.1; XM_001696210.1.
DR RefSeq; XP_001696277.1; XM_001696225.1.
DR RefSeq; XP_001696279.1; XM_001696227.1.
DR RefSeq; XP_001696285.1; XM_001696233.1.
DR RefSeq; XP_001696452.1; XM_001696400.1.
DR RefSeq; XP_001696459.1; XM_001696407.1.
DR RefSeq; XP_001696488.1; XM_001696436.1.
DR RefSeq; XP_001696520.1; XM_001696468.1.
DR RefSeq; XP_001696524.1; XM_001696472.1.
DR RefSeq; XP_001696553.1; XM_001696501.1.
DR RefSeq; XP_001698167.1; XM_001698115.1.
DR RefSeq; XP_001698253.1; XM_001698201.1.
DR RefSeq; XP_001698955.1; XM_001698903.1.
DR RefSeq; XP_001700398.1; XM_001700346.1.
DR RefSeq; XP_001700408.1; XM_001700356.1.
DR RefSeq; XP_001700424.1; XM_001700372.1.
DR RefSeq; XP_001700455.1; XM_001700403.1.
DR RefSeq; XP_001702964.1; XM_001702912.1.
DR RefSeq; XP_001703063.1; XM_001703011.1.
DR AlphaFoldDB; P50566; -.
DR SMR; P50566; -.
DR EnsemblPlants; PNW70160; PNW70160; CHLRE_17g708200v5.
DR EnsemblPlants; PNW70170; PNW70170; CHLRE_17g708650v5.
DR EnsemblPlants; PNW70179; PNW70179; CHLRE_17g709100v5.
DR EnsemblPlants; PNW70210; PNW70210; CHLRE_17g710500v5.
DR EnsemblPlants; PNW70245; PNW70245; CHLRE_17g711800v5.
DR EnsemblPlants; PNW70285; PNW70285; CHLRE_17g713500v5.
DR EnsemblPlants; PNW70298; PNW70298; CHLRE_17g714000v5.
DR EnsemblPlants; PNW70311; PNW70311; CHLRE_17g714600v5.
DR EnsemblPlants; PNW71335; PNW71335; CHLRE_16g649950v5.
DR EnsemblPlants; PNW71341; PNW71341; CHLRE_16g650250v5.
DR EnsemblPlants; PNW74880; PNW74880; CHLRE_12g506450v5.
DR EnsemblPlants; PNW74882; PNW74882; CHLRE_12g506350v5.
DR EnsemblPlants; PNW74898; PNW74898; CHLRE_12g505450v5.
DR EnsemblPlants; PNW74911; PNW74911; CHLRE_12g504850v5.
DR EnsemblPlants; PNW74916; PNW74916; CHLRE_12g504600v5.
DR EnsemblPlants; PNW81885; PNW81885; CHLRE_06g264600v5.
DR EnsemblPlants; PNW81894; PNW81894; CHLRE_06g265050v5.
DR EnsemblPlants; PNW81897; PNW81897; CHLRE_06g265200v5.
DR EnsemblPlants; PNW81902; PNW81902; CHLRE_06g265450v5.
DR EnsemblPlants; PNW81928; PNW81928; CHLRE_06g266600v5.
DR EnsemblPlants; PNW81959; PNW81959; CHLRE_06g268000v5.
DR EnsemblPlants; PNW81968; PNW81968; CHLRE_06g268400v5.
DR EnsemblPlants; PNW82040; PNW82040; CHLRE_06g271300v5.
DR EnsemblPlants; PNW82102; PNW82102; CHLRE_06g273950v5.
DR EnsemblPlants; PNW82106; PNW82106; CHLRE_06g274150v5.
DR EnsemblPlants; PNW82109; PNW82109; CHLRE_06g274300v5.
DR EnsemblPlants; PNW82121; PNW82121; CHLRE_06g274900v5.
DR EnsemblPlants; PNW82138; PNW82138; CHLRE_06g275700v5.
DR EnsemblPlants; PNW82163; PNW82163; CHLRE_06g276650v5.
DR EnsemblPlants; PNW82168; PNW82168; CHLRE_06g276800v5.
DR GeneID; 5716318; -.
DR GeneID; 5716449; -.
DR GeneID; 5716454; -.
DR GeneID; 5716482; -.
DR GeneID; 5716484; -.
DR GeneID; 5717133; -.
DR GeneID; 5717177; -.
DR GeneID; 5717957; -.
DR GeneID; 5721835; -.
DR GeneID; 5721892; -.
DR GeneID; 5721901; -.
DR GeneID; 5721962; -.
DR GeneID; 5721972; -.
DR GeneID; 5723807; -.
DR GeneID; 5724510; -.
DR GeneID; 5726000; -.
DR GeneID; 5726011; -.
DR GeneID; 5726025; -.
DR Gramene; PNW70160; PNW70160; CHLRE_17g708200v5.
DR Gramene; PNW70170; PNW70170; CHLRE_17g708650v5.
DR Gramene; PNW70179; PNW70179; CHLRE_17g709100v5.
DR Gramene; PNW70210; PNW70210; CHLRE_17g710500v5.
DR Gramene; PNW70245; PNW70245; CHLRE_17g711800v5.
DR Gramene; PNW70285; PNW70285; CHLRE_17g713500v5.
DR Gramene; PNW70298; PNW70298; CHLRE_17g714000v5.
DR Gramene; PNW70311; PNW70311; CHLRE_17g714600v5.
DR Gramene; PNW71335; PNW71335; CHLRE_16g649950v5.
DR Gramene; PNW71341; PNW71341; CHLRE_16g650250v5.
DR Gramene; PNW74880; PNW74880; CHLRE_12g506450v5.
DR Gramene; PNW74882; PNW74882; CHLRE_12g506350v5.
DR Gramene; PNW74898; PNW74898; CHLRE_12g505450v5.
DR Gramene; PNW74911; PNW74911; CHLRE_12g504850v5.
DR Gramene; PNW74916; PNW74916; CHLRE_12g504600v5.
DR Gramene; PNW81885; PNW81885; CHLRE_06g264600v5.
DR Gramene; PNW81894; PNW81894; CHLRE_06g265050v5.
DR Gramene; PNW81897; PNW81897; CHLRE_06g265200v5.
DR Gramene; PNW81902; PNW81902; CHLRE_06g265450v5.
DR Gramene; PNW81928; PNW81928; CHLRE_06g266600v5.
DR Gramene; PNW81959; PNW81959; CHLRE_06g268000v5.
DR Gramene; PNW81968; PNW81968; CHLRE_06g268400v5.
DR Gramene; PNW82040; PNW82040; CHLRE_06g271300v5.
DR Gramene; PNW82102; PNW82102; CHLRE_06g273950v5.
DR Gramene; PNW82106; PNW82106; CHLRE_06g274150v5.
DR Gramene; PNW82109; PNW82109; CHLRE_06g274300v5.
DR Gramene; PNW82121; PNW82121; CHLRE_06g274900v5.
DR Gramene; PNW82138; PNW82138; CHLRE_06g275700v5.
DR Gramene; PNW82163; PNW82163; CHLRE_06g276650v5.
DR Gramene; PNW82168; PNW82168; CHLRE_06g276800v5.
DR KEGG; cre:CHLRE_06g264600v5; -.
DR KEGG; cre:CHLRE_06g265050v5; -.
DR KEGG; cre:CHLRE_06g268000v5; -.
DR KEGG; cre:CHLRE_06g268400v5; -.
DR KEGG; cre:CHLRE_06g271300v5; -.
DR KEGG; cre:CHLRE_06g274900v5; -.
DR KEGG; cre:CHLRE_12g504600v5; -.
DR KEGG; cre:CHLRE_12g504850v5; -.
DR KEGG; cre:CHLRE_12g506350v5; -.
DR KEGG; cre:CHLRE_12g506450v5; -.
DR KEGG; cre:CHLRE_16g650250v5; -.
DR KEGG; cre:CHLRE_17g708200v5; -.
DR KEGG; cre:CHLRE_17g709100v5; -.
DR KEGG; cre:CHLRE_17g710500v5; -.
DR KEGG; cre:CHLRE_17g711800v5; -.
DR KEGG; cre:CHLRE_17g713500v5; -.
DR KEGG; cre:CHLRE_17g714000v5; -.
DR KEGG; cre:CHLRE_17g714600v5; -.
DR eggNOG; KOG3467; Eukaryota.
DR HOGENOM; CLU_109117_2_3_1; -.
DR OMA; RRNRNMS; -.
DR OrthoDB; 1594208at2759; -.
DR GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR CDD; cd00076; H4; 1.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR035425; CENP-T/H4_C.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR001951; Histone_H4.
DR InterPro; IPR019809; Histone_H4_CS.
DR Pfam; PF15511; CENP-T_C; 1.
DR PRINTS; PR00623; HISTONEH4.
DR SMART; SM00417; H4; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
DR PROSITE; PS00047; HISTONE_H4; 1.
PE 3: Inferred from homology;
KW Chromosome; DNA-binding; Nucleosome core; Nucleus.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..103
FT /note="Histone H4"
FT /id="PRO_0000158299"
FT DNA_BIND 17..21
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 103 AA; 11457 MW; 62973B661293637F CRC64;
MSGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL IYEETRTVLK
TFLENVIRDS VTYTEHARRK TVTAMDVVYA LKRQGRTLYG FGG
