H4_DROSE
ID H4_DROSE Reviewed; 103 AA.
AC Q76FD9; B4HEK9;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Histone H4;
GN Name=His4; Synonyms=H4;
GN and
GN ORFNames=GM11149;
GN and
GN ORFNames=GM11159;
GN and
GN ORFNames=GM11162;
GN and
GN ORFNames=GM11187;
GN and
GN ORFNames=GM11683;
GN and
GN ORFNames=GM11713;
GN and
GN ORFNames=GM11715;
GN and
GN ORFNames=GM11745;
GN and
GN ORFNames=GM11749;
GN and
GN ORFNames=GM11845;
GN and
GN ORFNames=GM12950;
GN and
GN ORFNames=GM13120;
GN and
GN ORFNames=GM13125;
GN and
GN ORFNames=GM13140;
GN and
GN ORFNames=GM13168;
GN and
GN ORFNames=GM13186;
GN and
GN ORFNames=GM13190;
GN and
GN ORFNames=GM13192;
GN and
GN ORFNames=GM13525;
GN and
GN ORFNames=GM13538;
GN and
GN ORFNames=GM13562;
GN and
GN ORFNames=GM13630;
GN and
GN ORFNames=GM13631;
GN and
GN ORFNames=GM14868;
GN and
GN ORFNames=GM15136;
GN and
GN ORFNames=GM15454;
GN and
GN ORFNames=GM16107;
GN and
GN ORFNames=GM16109;
GN and
GN ORFNames=GM16164;
GN and
GN ORFNames=GM16185;
GN and
GN ORFNames=GM16230;
GN and
GN ORFNames=GM16393;
GN and
GN ORFNames=GM16879;
GN and
GN ORFNames=GM16891;
GN and
GN ORFNames=GM16925;
GN and
GN ORFNames=GM17443;
GN and
GN ORFNames=GM18806;
GN and
GN ORFNames=GM18818;
GN and
GN ORFNames=GM18833;
GN and
GN ORFNames=GM19313;
GN and
GN ORFNames=GM19317;
GN and
GN ORFNames=GM19324;
GN and
GN ORFNames=GM19326;
GN and
GN ORFNames=GM19340;
GN and
GN ORFNames=GM19352;
GN and
GN ORFNames=GM19376;
GN and
GN ORFNames=GM19601;
GN and
GN ORFNames=GM19626;
GN and
GN ORFNames=GM19645;
GN and
GN ORFNames=GM19693;
GN and
GN ORFNames=GM19694;
GN and
GN ORFNames=GM19700;
GN and
GN ORFNames=GM19704;
GN and
GN ORFNames=GM19705;
GN and
GN ORFNames=GM19735;
GN and
GN ORFNames=GM19737;
GN and
GN ORFNames=GM20007;
GN and
GN ORFNames=GM22033;
GN and
GN ORFNames=GM22670;
GN and
GN ORFNames=GM24174;
GN and
GN ORFNames=GM24351;
GN and
GN ORFNames=GM26662;
GN and
GN ORFNames=GM26664;
GN and
GN ORFNames=GM26728;
OS Drosophila sechellia (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7238;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (HIS4).
RX PubMed=14676429; DOI=10.1266/ggs.78.383;
RA Kakita M., Shimizu T., Emoto M., Nagai M., Takeguchi M., Hosono Y.,
RA Kume N., Ozawa T., Ueda M., Bhuiyan M.S., Matsuo Y.;
RT "Divergence and heterogeneity of the histone gene repeating units in the
RT Drosophila melanogaster species subgroup.";
RL Genes Genet. Syst. 78:383-389(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (GM11149; GM11159; GM11162;
RP GM11187; GM11683; GM11713; GM11715; GM11745; GM11749; GM11845; GM12950;
RP GM13120; GM13125; GM13140; GM13168; GM13186; GM13190; GM13192; GM13525;
RP GM13538; GM13562; GM13630; GM13631; GM14868; GM15136; GM15454; GM16107;
RP GM16109; GM16164; GM16185; GM16230; GM16393; GM16879; GM16891; GM16925;
RP GM17443; GM18806; GM18818; GM18833; GM19313; GM19317; GM19324; GM19326;
RP GM19340; GM19352; GM19376; GM19601; GM19626; GM19645; GM19693; GM19694;
RP GM19700; GM19704; GM19705; GM19735; GM19737; GM20007; GM22033; GM22670;
RP GM24174; GM24351; GM26662; GM26664 AND GM26728).
RC STRAIN=Rob3c / Tucson 14021-0248.25;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC DNA into chromatin, limiting DNA accessibility to the cellular
CC machineries which require DNA as a template. Histones thereby play a
CC central role in transcription regulation, DNA repair, DNA replication
CC and chromosomal stability. DNA accessibility is regulated via a complex
CC set of post-translational modifications of histones, also called
CC histone code, and nucleosome remodeling.
CC -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC DNA.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the histone H4 family. {ECO:0000305}.
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DR EMBL; AB105184; BAD02440.1; -; Genomic_DNA.
DR EMBL; AB105185; BAD02444.1; -; Genomic_DNA.
DR EMBL; CH480815; EDW42166.1; -; Genomic_DNA.
DR EMBL; CH480906; EDW56415.1; -; Genomic_DNA.
DR EMBL; CH480906; EDW56418.1; -; Genomic_DNA.
DR EMBL; CH480906; EDW56428.1; -; Genomic_DNA.
DR EMBL; CH480906; EDW56442.1; -; Genomic_DNA.
DR EMBL; CH481029; EDW48891.1; -; Genomic_DNA.
DR EMBL; CH481037; EDW49035.1; -; Genomic_DNA.
DR EMBL; CH481037; EDW49040.1; -; Genomic_DNA.
DR EMBL; CH481037; EDW49044.1; -; Genomic_DNA.
DR EMBL; CH481158; EDW51457.1; -; Genomic_DNA.
DR EMBL; CH481158; EDW51462.1; -; Genomic_DNA.
DR EMBL; CH481183; EDW52636.1; -; Genomic_DNA.
DR EMBL; CH481193; EDW52675.1; -; Genomic_DNA.
DR EMBL; CH481254; EDW52839.1; -; Genomic_DNA.
DR EMBL; CH481254; EDW52843.1; -; Genomic_DNA.
DR EMBL; CH481291; EDW53730.1; -; Genomic_DNA.
DR EMBL; CH481424; EDW55360.1; -; Genomic_DNA.
DR EMBL; CH481534; EDW55917.1; -; Genomic_DNA.
DR EMBL; CH676513; EDW53644.1; -; Genomic_DNA.
DR EMBL; CH676513; EDW53649.1; -; Genomic_DNA.
DR EMBL; CH676531; EDW53866.1; -; Genomic_DNA.
DR EMBL; CH676597; EDW55859.1; -; Genomic_DNA.
DR EMBL; CH676687; EDW43606.1; -; Genomic_DNA.
DR EMBL; CH676687; EDW43610.1; -; Genomic_DNA.
DR EMBL; CH677319; EDW48753.1; -; Genomic_DNA.
DR EMBL; CH677970; EDW49763.1; -; Genomic_DNA.
DR EMBL; CH678052; EDW50883.1; -; Genomic_DNA.
DR EMBL; CH678148; EDW50947.1; -; Genomic_DNA.
DR EMBL; CH678254; EDW51028.1; -; Genomic_DNA.
DR EMBL; CH678310; EDW51099.1; -; Genomic_DNA.
DR EMBL; CH678886; EDW51646.1; -; Genomic_DNA.
DR EMBL; CH679257; EDW52709.1; -; Genomic_DNA.
DR EMBL; CH679359; EDW52722.1; -; Genomic_DNA.
DR EMBL; CH680125; EDW53700.1; -; Genomic_DNA.
DR EMBL; CH681102; EDW54674.1; -; Genomic_DNA.
DR EMBL; CH681475; EDW54713.1; -; Genomic_DNA.
DR EMBL; CH681580; EDW54722.1; -; Genomic_DNA.
DR EMBL; CH682391; EDW55400.1; -; Genomic_DNA.
DR EMBL; CH682516; EDW55410.1; -; Genomic_DNA.
DR EMBL; CH682536; EDW55412.1; -; Genomic_DNA.
DR EMBL; CH682669; EDW55421.1; -; Genomic_DNA.
DR EMBL; CH682862; EDW55455.1; -; Genomic_DNA.
DR EMBL; CH682935; EDW55848.1; -; Genomic_DNA.
DR EMBL; CH683582; EDW55906.1; -; Genomic_DNA.
DR EMBL; CH683813; EDW55929.1; -; Genomic_DNA.
DR EMBL; CH683819; EDW55930.1; -; Genomic_DNA.
DR EMBL; CH684099; EDW56412.1; -; Genomic_DNA.
DR EMBL; CH684155; EDW56447.1; -; Genomic_DNA.
DR EMBL; CH684275; EDW56464.1; -; Genomic_DNA.
DR EMBL; CH684297; EDW56468.1; -; Genomic_DNA.
DR EMBL; CH684477; EDW56485.1; -; Genomic_DNA.
DR EMBL; CH684629; EDW56501.1; -; Genomic_DNA.
DR EMBL; CH684864; EDW56521.1; -; Genomic_DNA.
DR EMBL; CH684964; EDW43588.1; -; Genomic_DNA.
DR EMBL; CH685583; EDW43639.1; -; Genomic_DNA.
DR EMBL; CH685829; EDW43662.1; -; Genomic_DNA.
DR EMBL; CH686202; EDW44101.1; -; Genomic_DNA.
DR EMBL; CH686871; EDW44150.1; -; Genomic_DNA.
DR EMBL; CH687252; EDW44549.1; -; Genomic_DNA.
DR EMBL; CH687676; EDW44583.1; -; Genomic_DNA.
DR EMBL; CH688009; EDW44916.1; -; Genomic_DNA.
DR EMBL; CH688133; EDW44927.1; -; Genomic_DNA.
DR EMBL; CH688452; EDW44949.1; -; Genomic_DNA.
DR EMBL; CH688634; EDW44969.1; -; Genomic_DNA.
DR RefSeq; XP_002031180.1; XM_002031144.1.
DR RefSeq; XP_002044742.1; XM_002044706.1.
DR RefSeq; XP_002044745.1; XM_002044709.1.
DR RefSeq; XP_002044755.1; XM_002044719.1.
DR RefSeq; XP_002044769.1; XM_002044733.1.
DR RefSeq; XP_002044951.1; XM_002044915.1.
DR RefSeq; XP_002044954.1; XM_002044918.1.
DR RefSeq; XP_002044959.1; XM_002044923.1.
DR RefSeq; XP_002044963.1; XM_002044927.1.
DR RefSeq; XP_002045028.1; XM_002044992.1.
DR RefSeq; XP_002045033.1; XM_002044997.1.
DR RefSeq; XP_002045050.1; XM_002045014.1.
DR RefSeq; XP_002045059.1; XM_002045023.1.
DR RefSeq; XP_002045091.1; XM_002045055.1.
DR RefSeq; XP_002045095.1; XM_002045059.1.
DR RefSeq; XP_002045108.1; XM_002045072.1.
DR RefSeq; XP_002045140.1; XM_002045104.1.
DR RefSeq; XP_002045157.1; XM_002045121.1.
DR RefSeq; XP_002045355.1; XM_002045319.1.
DR RefSeq; XP_002045360.1; XM_002045324.1.
DR RefSeq; XP_002045367.1; XM_002045331.1.
DR RefSeq; XP_002045391.1; XM_002045355.1.
DR RefSeq; XP_002045406.1; XM_002045370.1.
DR RefSeq; XP_002045410.1; XM_002045374.1.
DR RefSeq; XP_002045458.1; XM_002045422.1.
DR RefSeq; XP_002045487.1; XM_002045451.1.
DR RefSeq; XP_002045493.1; XM_002045457.1.
DR RefSeq; XP_002045501.1; XM_002045465.1.
DR RefSeq; XP_002045515.1; XM_002045479.1.
DR RefSeq; XP_002045521.1; XM_002045485.1.
DR RefSeq; XP_002045549.1; XM_002045513.1.
DR RefSeq; XP_002045562.1; XM_002045526.1.
DR RefSeq; XP_002045567.1; XM_002045531.1.
DR RefSeq; XP_002045594.1; XM_002045558.1.
DR RefSeq; XP_002045640.1; XM_002045604.1.
DR RefSeq; XP_002045655.1; XM_002045619.1.
DR RefSeq; XP_002045661.1; XM_002045625.1.
DR RefSeq; XP_002045684.1; XM_002045648.1.
DR RefSeq; XP_002045688.1; XM_002045652.1.
DR RefSeq; XP_002045690.1; XM_002045654.1.
DR RefSeq; XP_002045698.1; XM_002045662.1.
DR RefSeq; XP_002045710.1; XM_002045674.1.
DR RefSeq; XP_002045716.1; XM_002045680.1.
DR RefSeq; XP_002045751.1; XM_002045715.1.
DR RefSeq; XP_002045763.1; XM_002045727.1.
DR RefSeq; XP_002045764.1; XM_002045728.1.
DR RefSeq; XP_002045780.1; XM_002045744.1.
DR RefSeq; XP_002045783.1; XM_002045747.1.
DR RefSeq; XP_002045798.1; XM_002045762.1.
DR RefSeq; XP_002045802.1; XM_002045766.1.
DR RefSeq; XP_002045810.1; XM_002045774.1.
DR RefSeq; XP_002045822.1; XM_002045786.1.
DR RefSeq; XP_002045834.1; XM_002045798.1.
DR RefSeq; XP_002045836.1; XM_002045800.1.
DR RefSeq; XP_002045864.1; XM_002045828.1.
DR RefSeq; XP_002045880.1; XM_002045844.1.
DR RefSeq; XP_002045896.1; XM_002045860.1.
DR RefSeq; XP_002045928.1; XM_002045892.1.
DR RefSeq; XP_002045938.1; XM_002045902.1.
DR RefSeq; XP_002045957.1; XM_002045921.1.
DR RefSeq; XP_002045976.1; XM_002045940.1.
DR RefSeq; XP_002045986.1; XM_002045950.1.
DR RefSeq; XP_002046001.1; XM_002045965.1.
DR RefSeq; XP_002046011.1; XM_002045975.1.
DR AlphaFoldDB; Q76FD9; -.
DR SMR; Q76FD9; -.
DR EnsemblMetazoa; FBtr0194134; FBpp0192626; FBgn0166094.
DR EnsemblMetazoa; FBtr0194144; FBpp0192636; FBgn0166104.
DR EnsemblMetazoa; FBtr0194147; FBpp0192639; FBgn0166107.
DR EnsemblMetazoa; FBtr0194172; FBpp0192664; FBgn0166132.
DR EnsemblMetazoa; FBtr0194668; FBpp0193160; FBgn0166626.
DR EnsemblMetazoa; FBtr0194698; FBpp0193190; FBgn0166656.
DR EnsemblMetazoa; FBtr0194700; FBpp0193192; FBgn0166658.
DR EnsemblMetazoa; FBtr0194730; FBpp0193222; FBgn0166688.
DR EnsemblMetazoa; FBtr0194734; FBpp0193226; FBgn0166692.
DR EnsemblMetazoa; FBtr0194830; FBpp0193322; FBgn0166786.
DR EnsemblMetazoa; FBtr0195935; FBpp0194427; FBgn0167882.
DR EnsemblMetazoa; FBtr0196105; FBpp0194597; FBgn0168051.
DR EnsemblMetazoa; FBtr0196110; FBpp0194602; FBgn0168056.
DR EnsemblMetazoa; FBtr0196125; FBpp0194617; FBgn0168071.
DR EnsemblMetazoa; FBtr0196153; FBpp0194645; FBgn0168099.
DR EnsemblMetazoa; FBtr0196171; FBpp0194663; FBgn0168117.
DR EnsemblMetazoa; FBtr0196175; FBpp0194667; FBgn0168121.
DR EnsemblMetazoa; FBtr0196177; FBpp0194669; FBgn0168123.
DR EnsemblMetazoa; FBtr0196510; FBpp0195002; FBgn0168456.
DR EnsemblMetazoa; FBtr0196523; FBpp0195015; FBgn0168469.
DR EnsemblMetazoa; FBtr0196547; FBpp0195039; FBgn0168493.
DR EnsemblMetazoa; FBtr0196615; FBpp0195107; FBgn0168561.
DR EnsemblMetazoa; FBtr0196616; FBpp0195108; FBgn0168562.
DR EnsemblMetazoa; FBtr0197853; FBpp0196345; FBgn0169789.
DR EnsemblMetazoa; FBtr0198121; FBpp0196613; FBgn0170056.
DR EnsemblMetazoa; FBtr0198439; FBpp0196931; FBgn0170372.
DR EnsemblMetazoa; FBtr0199092; FBpp0197584; FBgn0171023.
DR EnsemblMetazoa; FBtr0199094; FBpp0197586; FBgn0171025.
DR EnsemblMetazoa; FBtr0199149; FBpp0197641; FBgn0171080.
DR EnsemblMetazoa; FBtr0199170; FBpp0197662; FBgn0171101.
DR EnsemblMetazoa; FBtr0199215; FBpp0197707; FBgn0171146.
DR EnsemblMetazoa; FBtr0199378; FBpp0197870; FBgn0171308.
DR EnsemblMetazoa; FBtr0199864; FBpp0198356; FBgn0171792.
DR EnsemblMetazoa; FBtr0199876; FBpp0198368; FBgn0171804.
DR EnsemblMetazoa; FBtr0199910; FBpp0198402; FBgn0171838.
DR EnsemblMetazoa; FBtr0200428; FBpp0198920; FBgn0172353.
DR EnsemblMetazoa; FBtr0201791; FBpp0200283; FBgn0173711.
DR EnsemblMetazoa; FBtr0201803; FBpp0200295; FBgn0173723.
DR EnsemblMetazoa; FBtr0201818; FBpp0200310; FBgn0173738.
DR EnsemblMetazoa; FBtr0202298; FBpp0200790; FBgn0174213.
DR EnsemblMetazoa; FBtr0202302; FBpp0200794; FBgn0174217.
DR EnsemblMetazoa; FBtr0202309; FBpp0200801; FBgn0174224.
DR EnsemblMetazoa; FBtr0202311; FBpp0200803; FBgn0174226.
DR EnsemblMetazoa; FBtr0202325; FBpp0200817; FBgn0174240.
DR EnsemblMetazoa; FBtr0202337; FBpp0200829; FBgn0174252.
DR EnsemblMetazoa; FBtr0202361; FBpp0200853; FBgn0174276.
DR EnsemblMetazoa; FBtr0202586; FBpp0201078; FBgn0174501.
DR EnsemblMetazoa; FBtr0202611; FBpp0201103; FBgn0174526.
DR EnsemblMetazoa; FBtr0202630; FBpp0201122; FBgn0174545.
DR EnsemblMetazoa; FBtr0202678; FBpp0201170; FBgn0174593.
DR EnsemblMetazoa; FBtr0202679; FBpp0201171; FBgn0174594.
DR EnsemblMetazoa; FBtr0202685; FBpp0201177; FBgn0174600.
DR EnsemblMetazoa; FBtr0202689; FBpp0201181; FBgn0174604.
DR EnsemblMetazoa; FBtr0202690; FBpp0201182; FBgn0174605.
DR EnsemblMetazoa; FBtr0202720; FBpp0201212; FBgn0174635.
DR EnsemblMetazoa; FBtr0202722; FBpp0201214; FBgn0174637.
DR EnsemblMetazoa; FBtr0202992; FBpp0201484; FBgn0174892.
DR EnsemblMetazoa; FBtr0205018; FBpp0203510; FBgn0176904.
DR EnsemblMetazoa; FBtr0205655; FBpp0204147; FBgn0177540.
DR EnsemblMetazoa; FBtr0207159; FBpp0205651; FBgn0179038.
DR EnsemblMetazoa; FBtr0207336; FBpp0205828; FBgn0179215.
DR EnsemblMetazoa; FBtr0209647; FBpp0208139; FBgn0181515.
DR EnsemblMetazoa; FBtr0209649; FBpp0208141; FBgn0181517.
DR EnsemblMetazoa; FBtr0209713; FBpp0208205; FBgn0181581.
DR GeneID; 6606375; -.
DR KEGG; dse:6606375; -.
DR FlyBase; FBgn0068722; Dsec\His4.
DR HOGENOM; CLU_109117_2_3_1; -.
DR OMA; RRNRNMS; -.
DR PhylomeDB; Q76FD9; -.
DR Proteomes; UP000001292; Unassembled WGS sequence.
DR GO; GO:0000786; C:nucleosome; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR GO; GO:0006334; P:nucleosome assembly; ISS:UniProtKB.
DR CDD; cd00076; H4; 1.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR035425; CENP-T/H4_C.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR001951; Histone_H4.
DR InterPro; IPR019809; Histone_H4_CS.
DR InterPro; IPR004823; TAF_TATA-bd_Histone-like_dom.
DR Pfam; PF15511; CENP-T_C; 1.
DR PRINTS; PR00623; HISTONEH4.
DR SMART; SM00417; H4; 1.
DR SMART; SM00803; TAF; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
DR PROSITE; PS00047; HISTONE_H4; 1.
PE 3: Inferred from homology;
KW Acetylation; Chromosome; DNA-binding; Nucleosome core; Nucleus;
KW Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..103
FT /note="Histone H4"
FT /id="PRO_0000158307"
FT DNA_BIND 17..21
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 6
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P84040"
FT MOD_RES 13
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P84040"
FT MOD_RES 32
FT /note="N6-succinyllysine"
FT /evidence="ECO:0000250|UniProtKB:P84040"
FT MOD_RES 78
FT /note="N6-succinyllysine"
FT /evidence="ECO:0000250|UniProtKB:P84040"
FT MOD_RES 80
FT /note="N6-succinyllysine"
FT /evidence="ECO:0000250|UniProtKB:P84040"
FT MOD_RES 81
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P84040"
FT MOD_RES 83
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P84040"
FT MOD_RES 92
FT /note="N6-succinyllysine"
FT /evidence="ECO:0000250|UniProtKB:P84040"
SQ SEQUENCE 103 AA; 11381 MW; DF3EB26393BD208C CRC64;
MTGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL IYEETRGVLK
VFLENVIRDA VTYTEHAKRK TVTAMDVVYA LKRQGRTLYG FGG