ID   H4_ENTHI                Reviewed;         118 AA.
AC   P40287;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Histone H4;
OS   Entamoeba histolytica.
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=5759;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=ATCC 30459 / HM-1:IMSS;
RA   Tanaka T.;
RL   Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   STRAIN=SFL-3;
RX   PubMed=7477106; DOI=10.1016/0166-6851(94)00044-n;
RA   Binder M., Ortner S., Plaimauer B., Fodinger M., Wiedermann G.,
RA   Scheiner O., Duchene M.;
RT   "Sequence and organization of an unusual histone H4 gene in the human
RT   parasite Entamoeba histolytica.";
RL   Mol. Biochem. Parasitol. 71:243-247(1995).
CC   -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC       DNA into chromatin, limiting DNA accessibility to the cellular
CC       machineries which require DNA as a template. Histones thereby play a
CC       central role in transcription regulation, DNA repair, DNA replication
CC       and chromosomal stability. DNA accessibility is regulated via a complex
CC       set of post-translational modifications of histones, also called
CC       histone code, and nucleosome remodeling.
CC   -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC       each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC       two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC       DNA.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the histone H4 family. {ECO:0000305}.
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DR   EMBL; L35898; AAB67323.1; -; mRNA.
DR   EMBL; X84010; CAA58833.1; -; mRNA.
DR   EMBL; X84009; CAA58831.1; -; Genomic_DNA.
DR   PIR; S52264; S52262.
DR   AlphaFoldDB; P40287; -.
DR   SMR; P40287; -.
DR   STRING; 5759.rna_EHI_023230-1; -.
DR   VEuPathDB; AmoebaDB:EHI5A_006250; -.
DR   VEuPathDB; AmoebaDB:EHI7A_024330; -.
DR   VEuPathDB; AmoebaDB:EHI8A_083340; -.
DR   VEuPathDB; AmoebaDB:EHI_023230; -.
DR   VEuPathDB; AmoebaDB:KM1_004770; -.
DR   eggNOG; KOG3467; Eukaryota.
DR   OMA; QKEHING; -.
DR   GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   CDD; cd00076; H4; 1.
DR   Gene3D; 1.10.20.10; -; 1.
DR   InterPro; IPR035425; CENP-T/H4_C.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR001951; Histone_H4.
DR   Pfam; PF15511; CENP-T_C; 1.
DR   PRINTS; PR00623; HISTONEH4.
DR   SMART; SM00417; H4; 1.
DR   SUPFAM; SSF47113; SSF47113; 1.
PE   3: Inferred from homology;
KW   Chromosome; DNA-binding; Nucleosome core; Nucleus.
FT   CHAIN           1..118
FT                   /note="Histone H4"
FT                   /id="PRO_0000158315"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   118 AA;  12870 MW;  D804259C36A81603 CRC64;
     MATDTGSGRG KGGKGVTLGK GSKGAKASKG GKRIRTKTQQ DALKGITKPA IRRLARRGGV
     KRINGAVYDE TRNVLKQFLE QVIRDSVTYT EHAKRRTVTA MDVVYALKRQ GRTLYGYS