H4_MAIZE
ID H4_MAIZE Reviewed; 103 AA.
AC P62787; P02308; P59258;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Histone H4;
GN Name=H4C7;
GN and
GN Name=H4C13;
GN and
GN Name=H4C14;
OS Zea mays (Maize).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX NCBI_TaxID=4577;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (H4C7 AND H4C14).
RX PubMed=3015736; DOI=10.1016/0378-1119(86)90301-x;
RA Philipps G., Chaubet N., Chaboute M.-E., Ehling M., Gigot C.;
RT "Genomic organization and nucleotide sequences of two corn histone H4
RT genes.";
RL Gene 42:225-229(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (H4C13).
RA Gigot C., Chaubet N., Chaboute M.-E., Ehling M., Philipps G.;
RT "Nucleotide sequences of two histone H3 and H4 genes of corn. Further
RT insight into the structure and organization of the histone genes in higher
RT plants.";
RL Physiol. Veg. 25:235-247(1987).
RN [3]
RP SUBCELLULAR LOCATION, AND METHYLATION AT LYS-21.
RX PubMed=16624902; DOI=10.1534/genetics.106.056853;
RA Shi J., Dawe R.K.;
RT "Partitioning of the maize epigenome by the number of methyl groups on
RT histone H3 lysines 9 and 27.";
RL Genetics 173:1571-1583(2006).
CC -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC DNA into chromatin, limiting DNA accessibility to the cellular
CC machineries which require DNA as a template. Histones thereby play a
CC central role in transcription regulation, DNA repair, DNA replication
CC and chromosomal stability. DNA accessibility is regulated via a complex
CC set of post-translational modifications of histones, also called
CC histone code, and nucleosome remodeling.
CC -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC DNA.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16624902}. Chromosome
CC {ECO:0000269|PubMed:16624902}.
CC -!- PTM: Lys-21Me2 and Lys-21Me3 not detected.
CC -!- SIMILARITY: Belongs to the histone H4 family. {ECO:0000305}.
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DR EMBL; M13370; AAA33475.1; -; Genomic_DNA.
DR EMBL; M13377; AAA33476.1; -; Genomic_DNA.
DR EMBL; M36659; AAA33474.1; -; Genomic_DNA.
DR PIR; A25642; HSZM4.
DR RefSeq; NP_001131585.1; NM_001138113.1.
DR RefSeq; NP_001278493.1; NM_001291564.1.
DR RefSeq; NP_001281194.1; NM_001294265.1.
DR RefSeq; NP_001313304.1; NM_001326375.1.
DR RefSeq; XP_008650256.1; XM_008652034.1.
DR RefSeq; XP_008656378.1; XM_008658156.1.
DR RefSeq; XP_008657088.1; XM_008658866.1.
DR RefSeq; XP_008668985.1; XM_008670763.1.
DR RefSeq; XP_008668988.1; XM_008670766.1.
DR RefSeq; XP_008673673.1; XM_008675451.1.
DR RefSeq; XP_008674854.1; XM_008676632.1.
DR AlphaFoldDB; P62787; -.
DR SMR; P62787; -.
DR STRING; 4577.AC196961.2_FGP003; -.
DR iPTMnet; P62787; -.
DR PaxDb; P62787; -.
DR EnsemblPlants; Zm00001eb072850_T001; Zm00001eb072850_P001; Zm00001eb072850.
DR EnsemblPlants; Zm00001eb099930_T001; Zm00001eb099930_P001; Zm00001eb099930.
DR EnsemblPlants; Zm00001eb123370_T001; Zm00001eb123370_P001; Zm00001eb123370.
DR EnsemblPlants; Zm00001eb123370_T002; Zm00001eb123370_P002; Zm00001eb123370.
DR EnsemblPlants; Zm00001eb148730_T001; Zm00001eb148730_P001; Zm00001eb148730.
DR EnsemblPlants; Zm00001eb187430_T001; Zm00001eb187430_P001; Zm00001eb187430.
DR EnsemblPlants; Zm00001eb313720_T001; Zm00001eb313720_P001; Zm00001eb313720.
DR EnsemblPlants; Zm00001eb313730_T001; Zm00001eb313730_P001; Zm00001eb313730.
DR EnsemblPlants; Zm00001eb321260_T001; Zm00001eb321260_P001; Zm00001eb321260.
DR EnsemblPlants; Zm00001eb336310_T001; Zm00001eb336310_P001; Zm00001eb336310.
DR EnsemblPlants; Zm00001eb351700_T001; Zm00001eb351700_P001; Zm00001eb351700.
DR EnsemblPlants; Zm00001eb428040_T001; Zm00001eb428040_P001; Zm00001eb428040.
DR GeneID; 100192931; -.
DR GeneID; 100278340; -.
DR GeneID; 100282268; -.
DR GeneID; 103631010; -.
DR GeneID; 103634846; -.
DR GeneID; 103635780; -.
DR GeneID; 103636523; -.
DR GeneID; 103646024; -.
DR GeneID; 103646028; -.
DR GeneID; 103649716; -.
DR GeneID; 103651039; -.
DR Gramene; Zm00001eb072850_T001; Zm00001eb072850_P001; Zm00001eb072850.
DR Gramene; Zm00001eb099930_T001; Zm00001eb099930_P001; Zm00001eb099930.
DR Gramene; Zm00001eb123370_T001; Zm00001eb123370_P001; Zm00001eb123370.
DR Gramene; Zm00001eb123370_T002; Zm00001eb123370_P002; Zm00001eb123370.
DR Gramene; Zm00001eb148730_T001; Zm00001eb148730_P001; Zm00001eb148730.
DR Gramene; Zm00001eb187430_T001; Zm00001eb187430_P001; Zm00001eb187430.
DR Gramene; Zm00001eb313720_T001; Zm00001eb313720_P001; Zm00001eb313720.
DR Gramene; Zm00001eb313730_T001; Zm00001eb313730_P001; Zm00001eb313730.
DR Gramene; Zm00001eb321260_T001; Zm00001eb321260_P001; Zm00001eb321260.
DR Gramene; Zm00001eb336310_T001; Zm00001eb336310_P001; Zm00001eb336310.
DR Gramene; Zm00001eb351700_T001; Zm00001eb351700_P001; Zm00001eb351700.
DR Gramene; Zm00001eb428040_T001; Zm00001eb428040_P001; Zm00001eb428040.
DR KEGG; zma:100192931; -.
DR KEGG; zma:100278340; -.
DR KEGG; zma:100282268; -.
DR KEGG; zma:103631010; -.
DR KEGG; zma:103634846; -.
DR KEGG; zma:103635780; -.
DR KEGG; zma:103636523; -.
DR KEGG; zma:103646024; -.
DR KEGG; zma:103646028; -.
DR KEGG; zma:103649716; -.
DR KEGG; zma:103651039; -.
DR MaizeGDB; 25155; -.
DR eggNOG; KOG3467; Eukaryota.
DR HOGENOM; CLU_109117_2_3_1; -.
DR OMA; QKEHING; -.
DR OrthoDB; 1564596at2759; -.
DR Proteomes; UP000007305; Chromosome 10.
DR Proteomes; UP000007305; Chromosome 2.
DR Proteomes; UP000007305; Chromosome 3.
DR Proteomes; UP000007305; Chromosome 4.
DR Proteomes; UP000007305; Chromosome 7.
DR Proteomes; UP000007305; Chromosome 8.
DR ExpressionAtlas; P62787; baseline and differential.
DR Genevisible; P62787; ZM.
DR GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0009414; P:response to water deprivation; IEA:EnsemblPlants.
DR CDD; cd00076; H4; 1.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR035425; CENP-T/H4_C.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR001951; Histone_H4.
DR InterPro; IPR019809; Histone_H4_CS.
DR Pfam; PF15511; CENP-T_C; 1.
DR PRINTS; PR00623; HISTONEH4.
DR SMART; SM00417; H4; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
DR PROSITE; PS00047; HISTONE_H4; 1.
PE 1: Evidence at protein level;
KW Acetylation; Chromosome; DNA-binding; Methylation; Nucleosome core;
KW Nucleus; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..103
FT /note="Histone H4"
FT /id="PRO_0000158324"
FT DNA_BIND 17..21
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250"
FT MOD_RES 6
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250"
FT MOD_RES 9
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250"
FT MOD_RES 13
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250"
FT MOD_RES 17
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250"
FT MOD_RES 21
FT /note="N6-acetyllysine; alternate"
FT /evidence="ECO:0000250"
FT MOD_RES 21
FT /note="N6-methyllysine; alternate"
FT /evidence="ECO:0000269|PubMed:16624902"
SQ SEQUENCE 103 AA; 11409 MW; A9FD57725A2A7598 CRC64;
MSGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL IYEETRGVLK
IFLENVIRDA VTYTEHARRK TVTAMDVVYA LKRQGRTLYG FGG
