H4_PHYPO
ID H4_PHYPO Reviewed; 103 AA.
AC P04915;
DT 13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Histone H4;
GN Name=H41;
GN and
GN Name=H42;
OS Physarum polycephalum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Myxogastria;
OC Myxogastromycetidae; Physariida; Physaraceae; Physarum.
OX NCBI_TaxID=5791;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2499687; DOI=10.1007/bf02103428;
RA Wilhelm M.L., Wilhelm F.-X.;
RT "Histone genes in Physarum polycephalum: transcription and analysis of the
RT flanking regions of the two H4 genes.";
RL J. Mol. Evol. 28:322-326(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3601677; DOI=10.1093/nar/15.13.5478;
RA Wilhelm M.L., Wilhelm F.-X.;
RT "Both histone H4 genes of Physarum polycephalum are interrupted by an
RT intervening sequence.";
RL Nucleic Acids Res. 15:5478-5478(1987).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6327366; DOI=10.1016/0014-5793(84)80256-2;
RA Wilhelm M.L., Wilhelm F.-X.;
RT "A transposon-like DNA fragment interrupts a Physarum polycephalum histone
RT H4 gene.";
RL FEBS Lett. 168:249-254(1984).
CC -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC DNA into chromatin, limiting DNA accessibility to the cellular
CC machineries which require DNA as a template. Histones thereby play a
CC central role in transcription regulation, DNA repair, DNA replication
CC and chromosomal stability. DNA accessibility is regulated via a complex
CC set of post-translational modifications of histones, also called
CC histone code, and nucleosome remodeling.
CC -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC DNA.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC -!- MISCELLANEOUS: The sequence of H41 is shown.
CC -!- SIMILARITY: Belongs to the histone H4 family. {ECO:0000305}.
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DR EMBL; X00449; CAA25140.1; -; Genomic_DNA.
DR EMBL; X15141; CAA33239.1; -; Genomic_DNA.
DR EMBL; X15142; CAA33240.1; -; Genomic_DNA.
DR EMBL; Y00366; CAA68442.1; -; Genomic_DNA.
DR PIR; A27859; A27859.
DR PIR; S10076; S10076.
DR AlphaFoldDB; P04915; -.
DR BMRB; P04915; -.
DR SMR; P04915; -.
DR GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR CDD; cd00076; H4; 1.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR035425; CENP-T/H4_C.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR001951; Histone_H4.
DR InterPro; IPR019809; Histone_H4_CS.
DR InterPro; IPR004823; TAF_TATA-bd_Histone-like_dom.
DR Pfam; PF15511; CENP-T_C; 1.
DR PRINTS; PR00623; HISTONEH4.
DR SMART; SM00417; H4; 1.
DR SMART; SM00803; TAF; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
DR PROSITE; PS00047; HISTONE_H4; 1.
PE 3: Inferred from homology;
KW Chromosome; DNA-binding; Nucleosome core; Nucleus.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000305"
FT CHAIN 2..103
FT /note="Histone H4"
FT /id="PRO_0000158347"
FT DNA_BIND 17..21
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 49
FT /note="N -> K (in H42)"
SQ SEQUENCE 103 AA; 11442 MW; 41EC45F872812105 CRC64;
MSGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISNT IYEETRGVLK
TFLENVIRDA VTYTEHARRK TVTAMDVVYA LKRQGRTLYG FGG
