ID   H4_SEPOF                Reviewed;          18 AA.
AC   Q7M3Z5;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Histone H4;
DE   Flags: Fragment;
OS   Sepia officinalis (Common cuttlefish).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC   Coleoidea; Decapodiformes; Sepiida; Sepiina; Sepiidae; Sepia.
OX   NCBI_TaxID=6610;
RN   [1] {ECO:0000305, ECO:0000312|PIR:A61321}
RP   PROTEIN SEQUENCE OF 2-18, AND ACETYLATION AT SER-2; LYS-6; LYS-13 AND
RP   LYS-17.
RC   TISSUE=Testis {ECO:0000269|PubMed:7262310};
RX   PubMed=7262310; DOI=10.1016/0014-5793(81)80079-8;
RA   Wouters-Tyrou D., Martin-Ponthieu A., Sautiere P., Biserte G.;
RT   "Acetylation of histone H4 in chicken erythrocyte and cuttle-fish testis
RT   chromatin.";
RL   FEBS Lett. 128:195-200(1981).
CC   -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC       DNA into chromatin, limiting DNA accessibility to the cellular
CC       machineries which require DNA as a template. Histones thereby play a
CC       central role in transcription regulation, DNA repair, DNA replication
CC       and chromosomal stability. DNA accessibility is regulated via a complex
CC       set of post-translational modifications of histones, also called
CC       histone code, and nucleosome remodeling.
CC   -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC       each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC       two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC       DNA.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the histone H4 family. {ECO:0000255}.
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DR   PIR; A61321; A61321.
DR   AlphaFoldDB; Q7M3Z5; -.
DR   iPTMnet; Q7M3Z5; -.
DR   GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Acetylation; Chromosome; Direct protein sequencing; DNA-binding;
KW   Nucleosome core; Nucleus.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:7262310"
FT   CHAIN           2..>18
FT                   /note="Histone H4"
FT                   /id="PRO_0000158358"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000269|PubMed:7262310"
FT   MOD_RES         6
FT                   /note="N6-acetyllysine; partial"
FT                   /evidence="ECO:0000269|PubMed:7262310"
FT   MOD_RES         13
FT                   /note="N6-acetyllysine; partial"
FT                   /evidence="ECO:0000269|PubMed:7262310"
FT   MOD_RES         17
FT                   /note="N6-acetyllysine; partial"
FT                   /evidence="ECO:0000269|PubMed:7262310"
FT   NON_TER         18
SQ   SEQUENCE   18 AA;  1702 MW;  EAE8EC24BB83E4BA CRC64;
     MSGRGKGGKG LGKGGAKR