H4_STRPU
ID H4_STRPU Reviewed; 103 AA.
AC P62783; P02306; P18678;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Histone H4;
OS Strongylocentrotus purpuratus (Purple sea urchin).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC Strongylocentrotus.
OX NCBI_TaxID=7668;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3697096; DOI=10.1093/nar/15.24.10569;
RA Maxson R., Mohun T., Gormezano G., Kedes L.;
RT "Evolution of late H2A, H2B, and H4 histone genes of the sea urchin,
RT Strongylocentrotus purpuratus.";
RL Nucleic Acids Res. 15:10569-10582(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3714486; DOI=10.1093/nar/14.11.4557;
RA Kaumeyer J.F., Weinberg E.S.;
RT "Sequence, organization and expression of late embryonic H3 and H4 histone
RT genes from the sea urchin, Strongylocentrotus purpuratus.";
RL Nucleic Acids Res. 14:4557-4576(1986).
RN [3]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=7013789; DOI=10.1021/bi00508a025;
RA Grunstein M., Diamond K.E., Knoppel E., Grunstein J.E.;
RT "Comparison of the early histone H4 gene sequence of Strongylocentrotus
RT purpuratus with maternal, early, and late histone H4 mRNA sequences.";
RL Biochemistry 20:1216-1223(1981).
RN [4]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=6439878; DOI=10.1007/bf02104728;
RA Yager L.N., Kaumeyer J.F., Weinberg E.S.;
RT "Evolving sea urchin histone genes -- nucleotide polymorphisms in the H4
RT gene and spacers of Strongylocentrotus purpuratus.";
RL J. Mol. Evol. 20:215-226(1984).
CC -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC DNA into chromatin, limiting DNA accessibility to the cellular
CC machineries which require DNA as a template. Histones thereby play a
CC central role in transcription regulation, DNA repair, DNA replication
CC and chromosomal stability. DNA accessibility is regulated via a complex
CC set of post-translational modifications of histones, also called
CC histone code, and nucleosome remodeling.
CC -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC DNA.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the histone H4 family. {ECO:0000305}.
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DR EMBL; X03952; CAA27581.1; -; Genomic_DNA.
DR EMBL; V01355; CAA24645.1; -; Genomic_DNA.
DR EMBL; X06639; CAA29847.1; -; Genomic_DNA.
DR EMBL; X06641; CAA29849.1; -; Genomic_DNA.
DR EMBL; M32426; AAA30054.1; -; mRNA.
DR PIR; A02643; HSUR4P.
DR PIR; S01618; S01618.
DR RefSeq; NP_999707.1; NM_214542.1.
DR RefSeq; NP_999713.1; NM_214548.1.
DR RefSeq; NP_999715.1; NM_214550.1.
DR RefSeq; NP_999716.1; NM_214551.1.
DR RefSeq; XP_001175485.3; XM_001175485.3.
DR RefSeq; XP_001177624.1; XM_001177624.2.
DR RefSeq; XP_001178441.3; XM_001178441.3.
DR RefSeq; XP_001178934.1; XM_001178934.3.
DR RefSeq; XP_011661644.1; XM_011663342.1.
DR RefSeq; XP_011663808.1; XM_011665506.1.
DR RefSeq; XP_011678157.1; XM_011679855.1.
DR RefSeq; XP_011679526.1; XM_011681224.1.
DR AlphaFoldDB; P62783; -.
DR SMR; P62783; -.
DR EnsemblMetazoa; NM_214542; NP_999707; GeneID_373325.
DR EnsemblMetazoa; NM_214548; NP_999713; LOC373341.
DR EnsemblMetazoa; NM_214550; NP_999715; LOC373343.
DR EnsemblMetazoa; NM_214551; NP_999716; LOC373346.
DR EnsemblMetazoa; XM_001175485; XP_001175485; LOC752187.
DR EnsemblMetazoa; XM_001177624; XP_001177624; LOC753782.
DR EnsemblMetazoa; XM_001178441; XP_001178441; LOC754479.
DR EnsemblMetazoa; XM_001178934; XP_001178934; LOC753944.
DR EnsemblMetazoa; XM_011665506; XP_011663808; LOC753158.
DR EnsemblMetazoa; XM_011681224; XP_011679526; LOC754292.
DR EnsemblMetazoa; XM_030981579; XP_030837439; LOC115922556.
DR EnsemblMetazoa; XM_030986826; XP_030842686; LOC115924509.
DR EnsemblMetazoa; XM_030986844; XP_030842704; LOC576388.
DR EnsemblMetazoa; XM_030987519; XP_030843379; LOC115924735.
DR GeneID; 373325; -.
DR GeneID; 373341; -.
DR GeneID; 373343; -.
DR GeneID; 373346; -.
DR GeneID; 752187; -.
DR GeneID; 753158; -.
DR GeneID; 753782; -.
DR GeneID; 753944; -.
DR GeneID; 754292; -.
DR GeneID; 754479; -.
DR KEGG; spu:373325; -.
DR KEGG; spu:373341; -.
DR KEGG; spu:373343; -.
DR KEGG; spu:373346; -.
DR KEGG; spu:752187; -.
DR KEGG; spu:753158; -.
DR KEGG; spu:753782; -.
DR KEGG; spu:753944; -.
DR KEGG; spu:754292; -.
DR KEGG; spu:754479; -.
DR CTD; 373325; -.
DR eggNOG; KOG3467; Eukaryota.
DR HOGENOM; CLU_109117_2_3_1; -.
DR InParanoid; P62783; -.
DR OMA; PSSHYKI; -.
DR OrthoDB; 1564596at2759; -.
DR PhylomeDB; P62783; -.
DR Proteomes; UP000007110; Unassembled WGS sequence.
DR GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0006334; P:nucleosome assembly; IBA:GO_Central.
DR CDD; cd00076; H4; 1.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR035425; CENP-T/H4_C.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR001951; Histone_H4.
DR InterPro; IPR019809; Histone_H4_CS.
DR Pfam; PF15511; CENP-T_C; 1.
DR PRINTS; PR00623; HISTONEH4.
DR SMART; SM00417; H4; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
DR PROSITE; PS00047; HISTONE_H4; 1.
PE 3: Inferred from homology;
KW Acetylation; Chromosome; DNA-binding; Methylation; Nucleosome core;
KW Nucleus; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..103
FT /note="Histone H4"
FT /id="PRO_0000158362"
FT DNA_BIND 17..21
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250"
FT MOD_RES 17
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250"
FT MOD_RES 21
FT /note="N6-methyllysine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 103 AA; 11369 MW; A9E5DFD3F8AF04FF CRC64;
MSGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL IYEETRGVLK
VFLENVIRDA VTYCEHAKRK TVTAMDVVYA LKRQGRTLYG FGG
