H4_VOLCA
ID H4_VOLCA Reviewed; 103 AA.
AC P08436;
DT 01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Histone H4;
GN Name=H4-I;
GN and
GN Name=H4-II;
OS Volvox carteri (Green alga).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Volvocaceae; Volvox.
OX NCBI_TaxID=3067;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=f. Nagariensis / HK10;
RX PubMed=2836811; DOI=10.1093/nar/16.9.4121;
RA Mueller K., Schmitt R.;
RT "Histone genes of Volvox carteri: DNA sequence and organization of two H3-
RT H4 gene loci.";
RL Nucleic Acids Res. 16:4121-4136(1988).
CC -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC DNA into chromatin, limiting DNA accessibility to the cellular
CC machineries which require DNA as a template. Histones thereby play a
CC central role in transcription regulation, DNA repair, DNA replication
CC and chromosomal stability. DNA accessibility is regulated via a complex
CC set of post-translational modifications of histones, also called
CC histone code, and nucleosome remodeling.
CC -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC DNA.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the histone H4 family. {ECO:0000305}.
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DR EMBL; X06963; CAA30034.1; -; Genomic_DNA.
DR EMBL; X06964; CAA30036.1; -; Genomic_DNA.
DR PIR; S00939; S00939.
DR RefSeq; XP_002945759.1; XM_002945713.1.
DR RefSeq; XP_002945760.1; XM_002945714.1.
DR RefSeq; XP_002945859.1; XM_002945813.1.
DR RefSeq; XP_002946211.1; XM_002946165.1.
DR RefSeq; XP_002947135.1; XM_002947089.1.
DR RefSeq; XP_002947388.1; XM_002947342.1.
DR RefSeq; XP_002947548.1; XM_002947502.1.
DR RefSeq; XP_002947987.1; XM_002947941.1.
DR RefSeq; XP_002952989.1; XM_002952943.1.
DR RefSeq; XP_002952990.1; XM_002952944.1.
DR RefSeq; XP_002955420.1; XM_002955374.1.
DR RefSeq; XP_002956802.1; XM_002956756.1.
DR RefSeq; XP_002956846.1; XM_002956800.1.
DR AlphaFoldDB; P08436; -.
DR BMRB; P08436; -.
DR SMR; P08436; -.
DR PRIDE; P08436; -.
DR GeneID; 9616617; -.
DR GeneID; 9620241; -.
DR GeneID; 9620374; -.
DR GeneID; 9620488; -.
DR GeneID; 9620873; -.
DR GeneID; 9621877; -.
DR GeneID; 9622568; -.
DR GeneID; 9622622; -.
DR GeneID; 9625364; -.
DR GeneID; 9625474; -.
DR GeneID; 9625494; -.
DR GeneID; 9625708; -.
DR GeneID; 9625709; -.
DR KEGG; vcn:VOLCADRAFT_102100; -.
DR KEGG; vcn:VOLCADRAFT_102370; -.
DR KEGG; vcn:VOLCADRAFT_55291; -.
DR KEGG; vcn:VOLCADRAFT_55394; -.
DR KEGG; vcn:VOLCADRAFT_55542; -.
DR KEGG; vcn:VOLCADRAFT_56769; -.
DR KEGG; vcn:VOLCADRAFT_57217; -.
DR KEGG; vcn:VOLCADRAFT_57294; -.
DR KEGG; vcn:VOLCADRAFT_63165; -.
DR KEGG; vcn:VOLCADRAFT_65854; -.
DR KEGG; vcn:VOLCADRAFT_67420; -.
DR KEGG; vcn:VOLCADRAFT_78755; -.
DR KEGG; vcn:VOLCADRAFT_88140; -.
DR OMA; RRNRNMS; -.
DR GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR CDD; cd00076; H4; 1.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR035425; CENP-T/H4_C.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR001951; Histone_H4.
DR InterPro; IPR019809; Histone_H4_CS.
DR Pfam; PF15511; CENP-T_C; 1.
DR PRINTS; PR00623; HISTONEH4.
DR SMART; SM00417; H4; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
DR PROSITE; PS00047; HISTONE_H4; 1.
PE 3: Inferred from homology;
KW Chromosome; DNA-binding; Nucleosome core; Nucleus.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000305"
FT CHAIN 2..103
FT /note="Histone H4"
FT /id="PRO_0000158372"
FT DNA_BIND 17..21
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 103 AA; 11470 MW; 6297265AE141637F CRC64;
MSGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL IYEETRTVLK
NFLENVIRDS VTYTEHARRK TVTAMDVVYA LKRQGRTLYG FGG
