H60B_MOUSE
ID H60B_MOUSE Reviewed; 251 AA.
AC B1B212;
DT 11-MAY-2016, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Histocompatibility antigen 60b {ECO:0000305};
DE Flags: Precursor;
GN Name=H60b {ECO:0000312|MGI:MGI:3649078};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:BAG12558.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, AND INDUCTION.
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAG12558.1};
RX PubMed=18209064; DOI=10.4049/jimmunol.180.3.1678;
RA Takada A., Yoshida S., Kajikawa M., Miyatake Y., Tomaru U., Sakai M.,
RA Chiba H., Maenaka K., Kohda D., Fugo K., Kasahara M.;
RT "Two novel NKG2D ligands of the mouse H60 family with differential
RT expression patterns and binding affinities to NKG2D.";
RL J. Immunol. 180:1678-1685(2008).
RN [2] {ECO:0000312|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Ligand for the KLRK1 immunosurveillance receptor. Binding to
CC KLRK1 stimulates cell lysis in vitro. {ECO:0000269|PubMed:18209064}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18209064};
CC Single-pass type I membrane protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: In strain C57BL/6J, strongly expressed in cardiac
CC muscle and skeletal muscle, with lower expression levels in spleen,
CC liver, kidney and thymus. In strain BALB/cJ, weakly expressed in
CC cardiac muscle, spleen, kidney and thymus.
CC {ECO:0000269|PubMed:18209064}.
CC -!- INDUCTION: Up-regulated in response to infection by murine
CC cytomegalovirus. {ECO:0000269|PubMed:18209064}.
CC -!- SIMILARITY: Belongs to the NKG2D ligand family. {ECO:0000305}.
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DR EMBL; AB284505; BAG12558.1; -; mRNA.
DR EMBL; AC159136; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC170753; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS48520.1; -.
DR RefSeq; NP_001171246.1; NM_001177775.1.
DR AlphaFoldDB; B1B212; -.
DR SMR; B1B212; -.
DR STRING; 10090.ENSMUSP00000117032; -.
DR GlyGen; B1B212; 4 sites.
DR PaxDb; B1B212; -.
DR PeptideAtlas; B1B212; -.
DR PRIDE; B1B212; -.
DR ProteomicsDB; 271128; -.
DR DNASU; 667281; -.
DR Ensembl; ENSMUST00000105522; ENSMUSP00000101161; ENSMUSG00000075297.
DR Ensembl; ENSMUST00000131558; ENSMUSP00000117032; ENSMUSG00000075297.
DR GeneID; 667281; -.
DR KEGG; mmu:667281; -.
DR UCSC; uc011xbl.1; mouse.
DR CTD; 667281; -.
DR MGI; MGI:3649078; H60b.
DR VEuPathDB; HostDB:ENSMUSG00000075297; -.
DR GeneTree; ENSGT00940000169591; -.
DR HOGENOM; CLU_096840_0_0_1; -.
DR InParanoid; B1B212; -.
DR OMA; LTWRESH; -.
DR OrthoDB; 1485610at2759; -.
DR PhylomeDB; B1B212; -.
DR TreeFam; TF339658; -.
DR BioGRID-ORCS; 667281; 1 hit in 73 CRISPR screens.
DR PRO; PR:B1B212; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; B1B212; protein.
DR Bgee; ENSMUSG00000075297; Expressed in granulocyte and 37 other tissues.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IDA:MGI.
DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IPI:MGI.
DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IPI:MGI.
DR Gene3D; 3.30.500.10; -; 1.
DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR SUPFAM; SSF54452; SSF54452; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Immunity; Membrane; Reference proteome;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..251
FT /note="Histocompatibility antigen 60b"
FT /id="PRO_5006716408"
FT TOPO_DOM 25..212
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 213..233
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 234..251
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT CARBOHYD 63
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 93
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 126
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 189
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 251 AA; 28224 MW; 9703177D1D0CE957 CRC64;
MAKSSLSLNW SLLVLLNFLG ATLSTGTDSL SCELTFNHRT LHGQCSVNGK TLLDFGDKKH
EGNATEMCAD LSQSLRELSE GMRNQQSGND ALNVTTQSQY NQGEFIGGFW AINTDEQHSI
YFYPLNMTWR ESHSDNSSAM EHWKNKNLEK DIRNVLIIYF SRCLNKLSPH FREMPKSKIK
VLDTTQNTNT TQIHPTVNNS QHNSDTQGLS FTWIVIICIG GIVSFMAFMV FAWCMLKKKK
GALCCSSSST T
