H60C_MOUSE
ID H60C_MOUSE Reviewed; 197 AA.
AC B1B213;
DT 11-MAY-2016, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Histocompatibility antigen 60c {ECO:0000305};
DE Flags: Precursor;
GN Name=H60c {ECO:0000312|MGI:MGI:3774845};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:BAG12559.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAG12559.1};
RX PubMed=18209064; DOI=10.4049/jimmunol.180.3.1678;
RA Takada A., Yoshida S., Kajikawa M., Miyatake Y., Tomaru U., Sakai M.,
RA Chiba H., Maenaka K., Kohda D., Fugo K., Kasahara M.;
RT "Two novel NKG2D ligands of the mouse H60 family with differential
RT expression patterns and binding affinities to NKG2D.";
RL J. Immunol. 180:1678-1685(2008).
RN [2] {ECO:0000312|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000312|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Ligand for the KLRK1 immunosurveillance receptor. Binding to
CC KLRK1 stimulates cell lysis in vitro. {ECO:0000269|PubMed:18209064}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18209064};
CC Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:18209064}.
CC -!- TISSUE SPECIFICITY: Expressed in skin, and weakly in large intestine.
CC {ECO:0000269|PubMed:18209064}.
CC -!- SIMILARITY: Belongs to the NKG2D ligand family. {ECO:0000305}.
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DR EMBL; AB284506; BAG12559.1; -; mRNA.
DR EMBL; AC157021; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS56668.1; -.
DR RefSeq; NP_001191845.1; NM_001204916.2.
DR AlphaFoldDB; B1B213; -.
DR SMR; B1B213; -.
DR STRING; 10090.ENSMUSP00000126536; -.
DR GlyGen; B1B213; 3 sites.
DR PaxDb; B1B213; -.
DR PRIDE; B1B213; -.
DR ProteomicsDB; 269761; -.
DR Ensembl; ENSMUST00000170893; ENSMUSP00000126536; ENSMUSG00000091618.
DR GeneID; 670558; -.
DR KEGG; mmu:670558; -.
DR UCSC; uc011wzv.1; mouse.
DR CTD; 670558; -.
DR MGI; MGI:3774845; H60c.
DR VEuPathDB; HostDB:ENSMUSG00000091618; -.
DR GeneTree; ENSGT00940000169591; -.
DR HOGENOM; CLU_096840_0_0_1; -.
DR InParanoid; B1B213; -.
DR OrthoDB; 1485610at2759; -.
DR PhylomeDB; B1B213; -.
DR TreeFam; TF339658; -.
DR BioGRID-ORCS; 670558; 1 hit in 72 CRISPR screens.
DR PRO; PR:B1B213; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; B1B213; protein.
DR Bgee; ENSMUSG00000091618; Expressed in tail skin and 44 other tissues.
DR ExpressionAtlas; B1B213; baseline and differential.
DR GO; GO:0046658; C:anchored component of plasma membrane; IDA:MGI.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IPI:MGI.
DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IPI:MGI.
DR Gene3D; 3.30.500.10; -; 1.
DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR SUPFAM; SSF54452; SSF54452; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; GPI-anchor; Immunity; Lipoprotein; Membrane;
KW Reference proteome; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..177
FT /note="Histocompatibility antigen 60c"
FT /id="PRO_5006716406"
FT PROPEP 178..197
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000436149"
FT LIPID 177
FT /note="GPI-anchor amidated serine"
FT /evidence="ECO:0000255"
FT CARBOHYD 51
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 81
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 114
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 197 AA; 22340 MW; 5B12710EF5990DA6 CRC64;
MALLLLILES CSAGTYALNC KLTVKYRTLQ GLCSVNGKTF LDFGDENHEG NATMLCPALY
QSLTDISEVM WSLQSGNDAL NVTTRSQYYQ GEFIDGFWDI NTDEQHSIYV YPLNKTWRES
HSDNSSAMEQ WKNKNLEKDI RNVLMVDFSC CLNKSSPHFR EMPTLPTTAA HVDQPRSMAC
KSSPFDGLIM ILLIYIL
