ID   H7_VAR67                Reviewed;         146 AA.
AC   P0DON7; P33063;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   23-FEB-2022, entry version 6.
DE   RecName: Full=Late protein H7;
GN   ORFNames=H7R;
OS   Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=587200;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8383392; DOI=10.1016/0168-1702(93)90110-9;
RA   Shchelkunov S.N., Blinov V.M., Totmenin A.V., Marennikova S.S.,
RA   Kolykhalov A.A., Frolov I.V., Chizhikov V.E., Gytorov V.V., Gashikov P.V.,
RA   Belanov E.F., Belavin P.A., Resenchuk S.M., Andzhaparidze O.G.,
RA   Sandakhchiev L.S.;
RT   "Nucleotide sequence analysis of variola virus HindIII M, L, I genome
RT   fragments.";
RL   Virus Res. 27:25-35(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8384129; DOI=10.1016/0014-5793(93)80041-r;
RA   Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT   "Genes of variola and vaccinia viruses necessary to overcome the host
RT   protective mechanisms.";
RL   FEBS Lett. 319:80-83(1993).
CC   -!- FUNCTION: Contributes to the formation of crescents and immature
CC       virions (IV). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}. Note=Probably transitorily part of the membrane
CC       of crescents during immature virions formation. Not incorporated into
CC       virions. Probably synthesized, but not retained in viral factories (By
CC       similarity). {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae H7 family. {ECO:0000305}.
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DR   EMBL; X67119; CAA47589.1; -; Genomic_DNA.
DR   EMBL; S55844; AAB24686.1; -; Genomic_DNA.
DR   EMBL; X69198; CAA49031.1; -; Genomic_DNA.
DR   PIR; H72161; H72161.
DR   PIR; S33104; S33104.
DR   RefSeq; NP_042134.1; NC_001611.1.
DR   SMR; P0DON7; -.
DR   GeneID; 1486445; -.
DR   KEGG; vg:1486445; -.
DR   Proteomes; UP000002060; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR006872; Poxvirus_H7.
DR   Pfam; PF04787; Pox_H7; 1.
PE   2: Evidence at transcript level;
KW   Late protein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..146
FT                   /note="Late protein H7"
FT                   /id="PRO_0000099554"
FT   TRANSMEM        10..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   146 AA;  16900 MW;  CEAF85A690F1726A CRC64;
     MEMDKRMKSL AMTAFFGELT TLDIMALIMS IFKRHPNNTI FSVDKDGQFM IDFEYDTYKA
     SQYLDLPLTP ISGDECKTHA SSIAKQLACV DIIKEDISEY IKTTPRLKRF IKKYRNRSDT
     RISQDTEKLK IALAKGIDYE YIKDAC