H9A01_CYRHA
ID H9A01_CYRHA Reviewed; 86 AA.
AC D2Y236;
DT 02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 02-MAR-2010, sequence version 1.
DT 03-AUG-2022, entry version 28.
DE RecName: Full=Omega-theraphotoxin-Hhn1f 1;
DE Short=Omega-TRTX-Hhn1f;
DE AltName: Full=Hainantoxin-IX;
DE Short=HNTX-IX;
DE AltName: Full=Peptide F1-29.54;
DE Flags: Precursor;
OS Cyriopagopus hainanus (Chinese bird spider) (Haplopelma hainanum).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC Mygalomorphae; Theraphosidae; Haplopelma.
OX NCBI_TaxID=209901;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA / MRNA], PROTEIN SEQUENCE OF
RP 51-85, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Venom, and Venom gland;
RX PubMed=20192277; DOI=10.1021/pr1000016;
RA Tang X., Zhang Y., Hu W., Xu D., Tao H., Yang X., Li Y., Jiang L.,
RA Liang S.;
RT "Molecular diversification of peptide toxins from the tarantula Haplopelma
RT hainanum (Ornithoctonus hainana) venom based on transcriptomic, peptidomic,
RT and genomic analyses.";
RL J. Proteome Res. 9:2550-2564(2010).
CC -!- FUNCTION: Ion channel inhibitor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the neurotoxin 10 (Hwtx-1) family. 17 (Hntx-9)
CC subfamily. {ECO:0000305}.
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DR EMBL; GU292913; ADB56729.1; -; mRNA.
DR EMBL; GU293093; ADB56909.1; -; Genomic_DNA.
DR AlphaFoldDB; D2Y236; -.
DR SMR; D2Y236; -.
DR ArachnoServer; AS001945; omega-theraphotoxin-Hhn1f.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR011696; Huwentoxin-1.
DR InterPro; IPR013140; Huwentoxin_CS1.
DR Pfam; PF07740; Toxin_12; 1.
DR PROSITE; PS60021; HWTX_1; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW Knottin; Secreted; Signal; Toxin.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT PROPEP 22..50
FT /evidence="ECO:0000269|PubMed:20192277"
FT /id="PRO_0000400649"
FT PEPTIDE 51..86
FT /note="Omega-theraphotoxin-Hhn1f 1"
FT /id="PRO_0000400650"
FT DISULFID 52..66
FT /evidence="ECO:0000250"
FT DISULFID 59..71
FT /evidence="ECO:0000250"
FT DISULFID 65..78
FT /evidence="ECO:0000250"
SQ SEQUENCE 86 AA; 9673 MW; 19FED9BE7D66FAE6 CRC64;
MKSIVFVALF GLALLAVVCS ASEDAHKELL KEVVRAMVVD KTDAVQAEER ECRWYLGGCS
QDGDCCKHLQ CHSNYEWCIW DGTFSK