ID   HA19_MOUSE              Reviewed;         200 AA.
AC   P14431;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   25-MAY-2022, entry version 137.
DE   RecName: Full=H-2 class I histocompatibility antigen, Q9 alpha chain;
DE   Flags: Precursor; Fragment;
GN   Name=H2-Q9;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=C57BL/10;
RX   PubMed=3004940; DOI=10.1002/j.1460-2075.1985.tb04066.x;
RA   Devlin J.J., Weiss E.H., Paulson M., Flavell R.A.;
RT   "Duplicated gene pairs and alleles of class I genes in the Qa2 region of
RT   the murine major histocompatibility complex: a comparison.";
RL   EMBO J. 4:3203-3207(1985).
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC       microglobulin).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC   -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA27172.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; X03443; CAA27172.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; P14431; -.
DR   SMR; P14431; -.
DR   GlyGen; P14431; 1 site.
DR   EPD; P14431; -.
DR   jPOST; P14431; -.
DR   MaxQB; P14431; -.
DR   PRIDE; P14431; -.
DR   MGI; MGI:95938; H2-Q9.
DR   InParanoid; P14431; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; P14431; protein.
DR   GO; GO:0009986; C:cell surface; IDA:MGI.
DR   GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome.
DR   GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
DR   GO; GO:0032398; C:MHC class Ib protein complex; IDA:MGI.
DR   GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome.
DR   GO; GO:0042605; F:peptide antigen binding; IDA:MGI.
DR   GO; GO:0002476; P:antigen processing and presentation of endogenous peptide antigen via MHC class Ib; IDA:MGI.
DR   GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW.
DR   GO; GO:0071346; P:cellular response to interferon-gamma; IDA:MGI.
DR   GO; GO:0051607; P:defense response to virus; IDA:MGI.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IDA:MGI.
DR   GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IDA:MGI.
DR   Gene3D; 3.30.500.10; -; 1.
DR   InterPro; IPR011161; MHC_I-like_Ag-recog.
DR   InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR001039; MHC_I_a_a1/a2.
DR   Pfam; PF00129; MHC_I; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   SUPFAM; SSF54452; SSF54452; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Glycoprotein; Immunity; Membrane; MHC I;
KW   Reference proteome; Signal.
FT   SIGNAL          1..21
FT   CHAIN           22..>200
FT                   /note="H-2 class I histocompatibility antigen, Q9 alpha
FT                   chain"
FT                   /id="PRO_0000018935"
FT   TOPO_DOM        22..>200
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          22..111
FT                   /note="Alpha-1"
FT   REGION          112..>200
FT                   /note="Alpha-2"
FT   CARBOHYD        107
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        122..185
FT                   /evidence="ECO:0000250"
FT   NON_TER         200
SQ   SEQUENCE   200 AA;  23025 MW;  4C2B7B2D059EA82E CRC64;
     MALTMLLLLV AAALTLIETR AGQHSLQYFH TAVSRPGLGE PWFISVGYVD DTQFVRFDSD
     AENPRMEPRA RWMEQEGPEY WERETQIAKG HEQSFRGSLR TAQSYYNQSK GGSHTLQWMY
     GCDMGSDGRL LRGYLQFAYE GRDYIALNED LKTWTAVDMA AQITRRKWEQ AGIAEKDQAY
     LEGTCMQSLR RYLELGKETL