ID   HA1Z_MOUSE              Reviewed;         185 AA.
AC   P01896; Q31209;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 142.
DE   RecName: Full=H-2 class I histocompatibility antigen, alpha chain;
DE   AltName: Full=Clone PH-2D-2;
DE   Flags: Fragment;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=6786753; DOI=10.1016/0092-8674(81)90508-0;
RA   Steinmetz M., Frelinger J.G., Fisher D., Hunkapiller T., Pereira D.,
RA   Weissman S.M., Uehara H., Nathenson S.G., Hood L.E.;
RT   "Three cDNA clones encoding mouse transplantation antigens: homology to
RT   immunoglobulin genes.";
RL   Cell 24:125-134(1981).
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC       microglobulin).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass membrane
CC       protein {ECO:0000250}.
CC   -!- MISCELLANEOUS: Sequences of three cDNA clones that encode portions of
CC       three distinct histocompatibility antigen alpha chains are presented.
CC       These chains could not be precisely identified.
CC   -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}.
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DR   EMBL; J00407; AAA39698.1; -; mRNA.
DR   PIR; A02195; HLMS2.
DR   AlphaFoldDB; P01896; -.
DR   SMR; P01896; -.
DR   GlyGen; P01896; 2 sites.
DR   jPOST; P01896; -.
DR   MaxQB; P01896; -.
DR   PeptideAtlas; P01896; -.
DR   PRIDE; P01896; -.
DR   UCSC; uc008chh.1; mouse.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; P01896; protein.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome.
DR   GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
DR   GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome.
DR   GO; GO:0002476; P:antigen processing and presentation of endogenous peptide antigen via MHC class Ib; IBA:GO_Central.
DR   GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR010579; MHC_I_a_C.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; Immunity; Membrane; MHC I; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           <1..185
FT                   /note="H-2 class I histocompatibility antigen, alpha chain"
FT                   /id="PRO_0000080743"
FT   TOPO_DOM        <1..118
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        140..185
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          19..107
FT                   /note="Ig-like C1-type"
FT   CARBOHYD        10
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        90
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        149
FT                   /note="G -> A (in Ref. 1; AAA39698)"
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
SQ   SEQUENCE   185 AA;  20454 MW;  4652EAD04A255237 CRC64;
     WLHRYLKNGN ATLLRTDPPK AHVTHHRRPE GDVTLRCWAL GFYPADITLT WQLNGEELTQ
     DMELVETRPA GDGTFQKWAS VVVPLGKEQN YTCRVYHEGL PEPLTLRWEP PPSTDSYMVI
     VAVLGVLGAM AIIGAVVAFV MKRRRNTGGK GGDYALAPGS QSSEMSLRDC KGDTLGSDWG
     GAMWT