ID   HA22A_ARATH             Reviewed;         177 AA.
AC   Q9S7V4;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=HVA22-like protein a;
DE            Short=AtHVA22a;
GN   Name=HVA22A; OrderedLocusNames=At1g74520; ORFNames=F1M20.20;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, AND
RP   INDUCTION.
RC   STRAIN=cv. Columbia;
RX   PubMed=12081371; DOI=10.1023/a:1015593715144;
RA   Chen C.-N., Chu C.-C., Zentella R., Pan S.-M., Ho T.-H.D.;
RT   "AtHVA22 gene family in Arabidopsis: phylogenetic relationship, ABA and
RT   stress regulation, and tissue-specific expression.";
RL   Plant Mol. Biol. 49:633-644(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11910074; DOI=10.1126/science.1071006;
RA   Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA   Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA   Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA   Shinagawa A., Shinozaki K.;
RT   "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL   Science 296:141-145(2002).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Predominantly expressed in flower buds and stem.
CC       {ECO:0000269|PubMed:12081371}.
CC   -!- INDUCTION: By abscisic acid (ABA), cold, drought and salt stresses.
CC       {ECO:0000269|PubMed:12081371}.
CC   -!- SIMILARITY: Belongs to the DP1 family. {ECO:0000305}.
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DR   EMBL; AF141977; AAD31885.1; -; Genomic_DNA.
DR   EMBL; AF141659; AAD31879.1; -; mRNA.
DR   EMBL; AC011765; AAG52361.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE35603.1; -; Genomic_DNA.
DR   EMBL; CP002684; ANM60994.1; -; Genomic_DNA.
DR   EMBL; AK118825; BAC43415.1; -; mRNA.
DR   EMBL; BT005492; AAO63912.1; -; mRNA.
DR   PIR; C96774; C96774.
DR   RefSeq; NP_001323240.1; NM_001334652.1.
DR   RefSeq; NP_177592.1; NM_106112.3.
DR   AlphaFoldDB; Q9S7V4; -.
DR   BioGRID; 29012; 1.
DR   IntAct; Q9S7V4; 1.
DR   STRING; 3702.AT1G74520.1; -.
DR   PaxDb; Q9S7V4; -.
DR   PRIDE; Q9S7V4; -.
DR   ProteomicsDB; 247159; -.
DR   DNASU; 843793; -.
DR   EnsemblPlants; AT1G74520.1; AT1G74520.1; AT1G74520.
DR   EnsemblPlants; AT1G74520.2; AT1G74520.2; AT1G74520.
DR   GeneID; 843793; -.
DR   Gramene; AT1G74520.1; AT1G74520.1; AT1G74520.
DR   Gramene; AT1G74520.2; AT1G74520.2; AT1G74520.
DR   KEGG; ath:AT1G74520; -.
DR   Araport; AT1G74520; -.
DR   TAIR; locus:2019225; AT1G74520.
DR   eggNOG; KOG1725; Eukaryota.
DR   HOGENOM; CLU_098452_0_0_1; -.
DR   InParanoid; Q9S7V4; -.
DR   OMA; EWLPIWS; -.
DR   OrthoDB; 1473891at2759; -.
DR   PhylomeDB; Q9S7V4; -.
DR   PRO; PR:Q9S7V4; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9S7V4; baseline and differential.
DR   Genevisible; Q9S7V4; AT.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042538; P:hyperosmotic salinity response; IEP:TAIR.
DR   GO; GO:0009737; P:response to abscisic acid; IEP:TAIR.
DR   GO; GO:0009409; P:response to cold; IEP:TAIR.
DR   GO; GO:0009414; P:response to water deprivation; IEP:TAIR.
DR   InterPro; IPR004345; TB2_DP1_HVA22.
DR   PANTHER; PTHR12300; PTHR12300; 1.
DR   Pfam; PF03134; TB2_DP1_HVA22; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Stress response; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..177
FT                   /note="HVA22-like protein a"
FT                   /id="PRO_0000101835"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   177 AA;  20679 MW;  3B1B6DB5932DB4C2 CRC64;
     MGSGAGNFLK VLLRNFDVLA GPVVSLVYPL YASVQAIETQ SHADDKQWLT YWVLYSLLTL
     IELTFAKLIE WLPIWSYMKL ILTCWLVIPY FSGAAYVYEH FVRPVFVNPR SINIWYVPKK
     MDIFRKPDDV LTAAEKYIAE NGPDAFEKIL SRADKSKRYN KHEYESYETM YGEGYQY