HA2C_PIG
ID HA2C_PIG Reviewed; 254 AA.
AC P15980;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1990, sequence version 1.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=SLA class II histocompatibility antigen, DQ haplotype C alpha chain;
DE Flags: Precursor;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2298465; DOI=10.1007/bf00702489;
RA Hirsch F., Sachs D.H., Gustafsson K., Pratt K., Germana S., Leguern C.;
RT "Class II genes of miniature swine. III. Characterization of an expressed
RT pig class II gene homologous to HLA-DQA.";
RL Immunogenetics 31:52-56(1990).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the MHC class II family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M29938; AAA31082.1; -; mRNA.
DR PIR; I46605; I46605.
DR AlphaFoldDB; P15980; -.
DR SMR; P15980; -.
DR PeptideAtlas; P15980; -.
DR PRIDE; P15980; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0042613; C:MHC class II protein complex; IBA:GO_Central.
DR GO; GO:0023026; F:MHC class II protein complex binding; IBA:GO_Central.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IBA:GO_Central.
DR GO; GO:0002503; P:peptide antigen assembly with MHC class II protein complex; IBA:GO_Central.
DR GO; GO:0050870; P:positive regulation of T cell activation; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 3.10.320.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR014745; MHC_II_a/b_N.
DR InterPro; IPR001003; MHC_II_a_N.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00993; MHC_II_alpha; 1.
DR SMART; SM00407; IGc1; 1.
DR SMART; SM00920; MHC_II_alpha; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR SUPFAM; SSF54452; SSF54452; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 2: Evidence at transcript level;
KW Adaptive immunity; Disulfide bond; Glycoprotein; Immunity; Membrane;
KW MHC II; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..23
FT CHAIN 24..254
FT /note="SLA class II histocompatibility antigen, DQ
FT haplotype C alpha chain"
FT /id="PRO_0000018981"
FT TOPO_DOM 24..216
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 217..239
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 240..254
FT /note="Cytoplasmic"
FT DOMAIN 113..204
FT /note="Ig-like C1-type"
FT REGION 24..120
FT /note="Alpha-1"
FT REGION 121..203
FT /note="Alpha-2"
FT REGION 204..216
FT /note="Connecting peptide"
FT CARBOHYD 104
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 144
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 133..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 254 AA; 28054 MW; 6884206F32F04B33 CRC64;
MVPGRVLMWG ALALTTVMSA CGGEDIAADH VASYGLNVYQ SYGPRGYFTH EFDGDEQFYV
DLEKKETVWR LPLFSEFTSF DPQGALRNIA TLKHNLNIVT KRSNNTAAVN KVPEVTVFSK
SPVILGQPNT LICHVDSIFP PVINITWLKN GHSVKGFSET SFLSKNDHSF LKISYLTFLP
SDDDFYDCKV EHWGLDKPLL KHWEPEIPAP MSELTETVVC ALGLIVGLVG IVVGTVFIIQ
GLRSGGPSRH QGSL
