ID   HA2D_PIG                Reviewed;         255 AA.
AC   P15981;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=SLA class II histocompatibility antigen, DQ haplotype D alpha chain;
DE   Flags: Precursor;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2298465; DOI=10.1007/bf00702489;
RA   Hirsch F., Sachs D.H., Gustafsson K., Pratt K., Germana S., Leguern C.;
RT   "Class II genes of miniature swine. III. Characterization of an expressed
RT   pig class II gene homologous to HLA-DQA.";
RL   Immunogenetics 31:52-56(1990).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the MHC class II family. {ECO:0000305}.
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DR   EMBL; M29939; AAA31083.1; -; mRNA.
DR   PIR; I46606; I46606.
DR   AlphaFoldDB; P15981; -.
DR   SMR; P15981; -.
DR   STRING; 9823.ENSSSCP00000001574; -.
DR   PaxDb; P15981; -.
DR   PeptideAtlas; P15981; -.
DR   PRIDE; P15981; -.
DR   Ensembl; ENSSSCT00015099990; ENSSSCP00015041354; ENSSSCG00015063820.
DR   Ensembl; ENSSSCT00015100056; ENSSSCP00015041384; ENSSSCG00015063820.
DR   Ensembl; ENSSSCT00015101320; ENSSSCP00015041959; ENSSSCG00015063820.
DR   eggNOG; ENOG502RXYJ; Eukaryota.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042613; C:MHC class II protein complex; IBA:GO_Central.
DR   GO; GO:0023026; F:MHC class II protein complex binding; IBA:GO_Central.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IBA:GO_Central.
DR   GO; GO:0002503; P:peptide antigen assembly with MHC class II protein complex; IBA:GO_Central.
DR   GO; GO:0050870; P:positive regulation of T cell activation; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 3.10.320.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR014745; MHC_II_a/b_N.
DR   InterPro; IPR001003; MHC_II_a_N.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00993; MHC_II_alpha; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SMART; SM00920; MHC_II_alpha; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   SUPFAM; SSF54452; SSF54452; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   2: Evidence at transcript level;
KW   Adaptive immunity; Disulfide bond; Glycoprotein; Immunity; Membrane;
KW   MHC II; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..23
FT   CHAIN           24..255
FT                   /note="SLA class II histocompatibility antigen, DQ
FT                   haplotype D alpha chain"
FT                   /id="PRO_0000018982"
FT   TOPO_DOM        24..217
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        241..255
FT                   /note="Cytoplasmic"
FT   DOMAIN          113..205
FT                   /note="Ig-like C1-type"
FT   REGION          24..120
FT                   /note="Alpha-1"
FT   REGION          121..204
FT                   /note="Alpha-2"
FT   REGION          205..217
FT                   /note="Connecting peptide"
FT   CARBOHYD        104
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        144
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        133..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   255 AA;  28067 MW;  CFCBDED8476FAC8C CRC64;
     MVPGRVLMWG ALALTAVMSA CGGEDIAADH VASYGLNVYQ SYGPSGYYTH EFDGDEEFYV
     DLGKKETVWQ LPLFSKFRSF DPQGALRNIA TAKHNLNILI KRSNNTAAVN QVPEVTVFPK
     SPVMLGQPNT LICHVDNIFP PVINITWLKN GHSVTEGFSE TSFLSKNDHS FLKISYLTFL
     PSDDDFYDCK VEHWGLDKPL LKHWEPEIPA PMSELTETVV CALGLIVGLV GIVVGTVFII
     QGLRSGGPSR HQGSL