ID   HA2P_RABIT              Reviewed;         226 AA.
AC   P20755;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=RLA class II histocompatibility antigen, DP alpha-1 chain;
DE   AltName: Full=D10 haplotype;
DE   Flags: Fragment;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2834455;
RA   Sittisombut N., Mordacq J., Knight K.L.;
RT   "Rabbit MHC. II. Sequence analysis of the R-DP alpha- and beta-genes.";
RL   J. Immunol. 140:3237-3243(1988).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the MHC class II family. {ECO:0000305}.
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DR   EMBL; M22640; AAA31396.1; -; Genomic_DNA.
DR   PIR; B32283; B32283.
DR   AlphaFoldDB; P20755; -.
DR   SMR; P20755; -.
DR   STRING; 9986.ENSOCUP00000002876; -.
DR   eggNOG; ENOG502RXYJ; Eukaryota.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   GO; GO:0002504; P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; IEA:UniProtKB-KW.
DR   GO; GO:0002682; P:regulation of immune system process; IEA:UniProt.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 3.10.320.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR014745; MHC_II_a/b_N.
DR   InterPro; IPR001003; MHC_II_a_N.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00993; MHC_II_alpha; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SMART; SM00920; MHC_II_alpha; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   SUPFAM; SSF54452; SSF54452; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   3: Inferred from homology;
KW   Adaptive immunity; Disulfide bond; Glycoprotein; Immunity; Membrane;
KW   MHC II; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           <1..226
FT                   /note="RLA class II histocompatibility antigen, DP alpha-1
FT                   chain"
FT                   /id="PRO_0000080751"
FT   TOPO_DOM        <1..189
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        190..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        211..226
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          84..176
FT                   /note="Ig-like C1-type"
FT   CARBOHYD        75
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        115
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        104..160
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   NON_TER         1
SQ   SEQUENCE   226 AA;  25218 MW;  36D4A8B96F6CE7FE CRC64;
     EHVSVFVIFA QTHEPSGECM FEFDEDEVFH VDLDKKQAIW YLPEFGRMFS VEAQGGLANI
     AAAKSNLNAC IQHSNHTQAP NEPPEVIVFP KEPVELGQPN TLICHIDKFF PPVLNVTWLR
     NGQPVTEGVS ETVFLASTEF RFRKFHYLAF VPSAADVYDC RVEHWGLDAP LLTHWEAQEP
     IQMPETTETV VCALGLVVGL AGVVVGIVLI TKALRSSPDP RARRPL